Expression of TNF-?,MMP-9 and TIMP-1 in the lesions of psoriasis vulgaris / 西安交通大学学报(医学版)

Objective To study the role of TNF-?,MMP-9 and TIMP-1 in the lesions of psoriasis vulgaris.Methods SABC immunohistochemical technique was used to examine the expression of TNF-?,MMP-9 and TIMP-1 in lesional skin of 40 cases and uninvolved skin of 20 cases of psoriasis and in skin of 20 cases normal controls.Results The expression of TNF-? and MMP-9 was significantly higher in the lesional skin than that in nonlesional skin and normal controls(P0.05).There was a positive correlation between the expression of TNF-? and MMP-9(r=0.471,P