Preparation of Self-emulsifying Preparations of Chinese Medicinal Ingredients Based on Identical Carrier System and Investigation of Their Transdermal Absorption Characteristics in Vitro / 中国实验方剂学杂志

Objective:To prepare self-emulsifying carrier system which was suitable for three Chinese medicinal ingredients(baicalein,berberine and allicin),and investigate transdermal absorption effect in vitro of these three self-emulsifying preparations. Method:The optimum formulation and dosage were screened by the saturated solubility method,pseudo-ternary phase diagram method and orthogonal experiment.Transdermal absorption test in vitro was carried out with excised rats skin and Franz diffusion cell.The cumulative penetration amounts of baicalein,berberine and allicin in the identical self-emulsifying system were determined by HPLC and compared with baicalein powder,berberine powder and allicin powder,respectively. Result:The optimum formulation was ethyl oleate-cremophor RH40-polyethylene glycol(PEG)400.The self-emulsifying preparation had a suitable particle size with a relatively regular spherical shape.At 10 h of transdermal absorption,the transdermal rates of baicalein,berberine and allicin in identical self-emulsifying system were 6.898 6,7.600 4,190.040 μg·cm-2·h-1,the cumulative penetration amounts of them were 71.38,85.54,1 795.16 μg·cm-2,respectively. Conclusion:The self-emulsifying carrier system is prepared successfully,which can be used by different kinds of Chinese medicinal ingredients,and the transdermal absorption effect in vitro of these self-emulsifying preparations is good,which can provide experimental basis for the preparation and transdermal absorption of self-emulsifying preparation of Chinese herbal compound.

Optimization of matrix prescription of Compound Qingfengteng Cataplasm by orthogonal test method / 中草药

Objective: To optimize the matrix prescription of Compound Qingfengteng Cataplasm (CQC). Methods: Taking the comprehensive senses as evaluation index, the types and dosage of the matrix were investigated by single factor. Further combined with the initial viscosity and holding viscosity index to optimize the matrix prescription of CQC by orthogonal test, and in vitro transdermal absorption experiments were carried out by Franz diffusion pool method to screen penetration enhancers. Results: The optimal formulation of CQC was as follows: 2.5 g of NP-700, 11 g of glycerin, 0.08 g of glycine aluminum, 0.08 g of tartaric acid, 0.8 g of PVP K90, 0.5 g of PVPP, 20 g of water, and 4.2 g of dry extract. 3% nitrile as a penetration agent could enhance penetration action. Conclusion: The preferred matrix prescription is practicable; CQC adhesion is moderate, no residue, paste traits, skin followability are good.

Optimization of Matrix Prescription and Preparation Process of Xuanshe Painkillers Cataplasm Using Uniform Design / 中药新药与临床药理

Objective To optimize the formula ratio of matrix and the preparation process of Xuanshe Painkillers Cataplasm. Methods The optimal matrix prescription of Xuanshe Painkillers Cataplasm was optimized by uniform design,and the optimal preparation process was determined at the same time. The viscosity and the appearance of the Xuanshe Painkillers Cataplasm (film residue,uniformity,ductility,skin adhesive ability of the plaster)are used as indexes. Results The preparation process of Xuanshe Painkillers Cataplasm is good,and through the analysis of experimental data,the optimal ratio of the matrix is NP-700∶aluminum hydroxide ∶glycerol ∶0.1% tartrate solution=3∶0.3∶25∶5. Conclusion The Preparation process is good and the optimal matrix has moderate viscosity,no film residue,and with better uniformity,ductility and skin adhesive ability.