Résumé
Objective To study the similarities and differences in brain activation under N-back and DMTS paradigms of working memory. Methods Through searching of BrainMap function database by the combination keywords,a total of 122 articles with 122 experiments ( N-back: 67 experiments,937 sub-jects,900 foci;Delayed Matched to Sample: 55 experiments,806 subjects,872 foci). Maps were analyzed using the FDR PN (P<0. 0001) method based coordinates of the Montreal Neurological Institute ( MNI) space. Results In the combine of the N-back and DMTS paradigms,these regions were activated including the bilateral inferior parietal lobe (Left: -36,-52,44; Right: 38,-52,48) and insula(Left:-34,22,0;Right:34,24,2),the superior frontal gyrus (2,16,50) and inferior frontal gyrus (-44,8,30) of the left brain,and the middle frontal ( 46,36,24) and sub-gyral ( 30,4,56) of the right brain. The N-back paradigm was similar to the above results,whereas the DMTS paradigm only activated the precentral gyrus (-50,8, 34) of the left brain and the right insula ( 34,24,4) . Conclusion The neural circuit of working memory is the frontal-parietal networks. N-back paradigm with the brain activation consists to the neural circuit of work-ing memory. However,DMTS paradigm activates less brain regions and is inconsistent to the neurons of work-ing memory.
Résumé
Objecttive: The article analyzed how neurophysiological signals of adolescent's working memory(WM) change with increasing age.Methods: We recorded ERP from 52 healthy subjects aged from 14 to 22 years old in three groups.Our experiment consisted of 4 subexperiments and had two types of working memory tasks: spatial working memory and verbal working memory tasks,furthermore,every task included two levels of difficulty.Results: ①Reaction time was faster with increasing age,there was significant difference in accuracy of complicated tasks in different age groups with junior high school group significantly lower than others;②There was significant difference between junior high school group and college group in frontal P200 amplitude and its latency had no significant difference in the three groups;③Occipital P100 amplitude was descending when age was increasing and there had significant difference in latency between junior high school group and college group;④Occipital N160 amplitude was increasing with age and the latency was descending with age and there was significant difference between junior high school group and college group;⑤Average amplitude of parietal P300 was increasing with age and junior high school group's was significantly lower than the other two groups'.Conclusion: Teenager's working memory changes unevenly with age.