Pigmented Kamino bodies: a little-known histological finding. Prevalence in 19 cases of Reed nevus

Abstract The present study aimed to determine the prevalence of Kamino bodies in Reed nevus, since most studies to date show conflicting data on this issue. This was a retrospective observational study, in which the histopathology of 19 Reed nevus lesions were reviewed. The slides were stained by hematoxylin and eosin and periodic acid-Schiff, with a special focus placed on the identification of Kamino bodies. Some clinical data were also collected. The median patient age was 12 years (range of 2 to 58). The women to men ratio was 5:4. Lesions were located on different parts of the body. Kamino bodies were found in eleven lesions (57.89%). five showed pigmented Kamino bodies (26.31%), four non-pigmented Kamino bodies (21,05%), and 2 (10.52%) had both. Kamino bodies, pigmented or not, are a common histological finding in Reed nevus and may well represent a good marker to differentiate these from malignant melanomas.

Pathological features of spindle cell tumor of the uterine and broad ligament in 145 cases / 中国医师进修杂志

Objective To explore the types, clinical pathologic and immunohistochemical features of spindle cell tumors of the uterine and broad ligament. Methods Clinical pathological files of spindle cell tumors in the uterine and broad ligament from 2007.12 to 2015.12 were reviewed. Results The primary sites of the 145 cases was cervical in 11 cases (7.58%), uterine body in 119 cases (82.07%), the broad ligament in 12 cases (8.28%), and uterine or cervix and the abdominal wall in 3 case (2.07%). Histopathological types of the 145 cases was smooth muscle origin in 126 cases (86.90%), of which 120 cases had benign leiomyoma, 3 cases had uncertain malignant potential and 3 cases had leiomyosarcoma;endometrial stromal origin in 15 cases (10.34%), including endometrial stromal nodule (5 cases), endometrial stromal sarcoma (10 cases); endometrial stromal- variant (3 cases, 2.07%), including endometrial stromal nodule associated with smooth muscle differentiation (2 cases), endometrial stromal sarcoma associated with smooth muscle differentiation (1 case); gastrointestinal stromal tumor (1 case, 0.68%). Conclusions Origin of spindle cell tumors of the uterine and broad ligament is mainly smooth muscle, endometrial stromal origin, and endometrial stromal tumor variants, and gastrointestinal stromal tumors in rare cases. We need to combine the clinical site, pathological morphology and immunohistochemistry for diagnosis and differential diagnosis.

Nevo de células fusiformes de Reed na conjuntiva / Spindle cell nevus of Reed in the conjunctiva

Os autores relatam um caso de nevo de Reed, lesão que apresenta aspecto histológico de malignidade, mas tem evolução benigna. Paciente de 48 anos, masculino, cor parda, apresentava pterígio nasal no olho direito, associado a uma lesão pequena e pouco pigmentada localizada na cabeça do mesmo. Realizou-se exérese de ambos, sem intercorrências, sem sinais de recidiva. O exame histopatológico revelou lesão com bordas definidas, restrita ao epitélio, constituída por células fusiformes perpendiculares à superfície, com pigmentação melânica esparsa. O diagnóstico inicial foi nevo de Spitz, mas, posteriormente, chegou-se à conclusão que se tratava do nevo de células fusiformes de Reed. O presente relato é o segundo na literatura mundial e o primeiro no Brasil.

The authors report one case of nevus of Reed, which has histological aspect of malignancy, but a benign evolution. A 48-years-old brown skin male presented nasal pterygium in right eye, associated with a small and poorly pigmented lesion located on the pterygium head. Both were excised without complications and, currently, there is no recidivation. The histopathological examination revealed one lesion with defined edges, limited to the epithelium, consisted of spindle cells perpendiculars to the surface and with sparse melanin pigmentation. The initial diagnosis was Spitz nevus, but, afterwards, we concluded that was the spindle cell nevus of Reed. This report is the second in the international literature and the first in Brazil.

Melanoma maligno y diagnóstico diferencial de lesiones pigmentadas en piel / Malignant melanoma and differential diagnosis of pigmented lesions of the skin

El enfrentamiento a una lesión pigmentada cutánea es frecuente en la práctica médica diaria. Dado que el diagnóstico diferencial incluye al Melanoma Maligno (MM) y considerando que su pronóstico está claramente determinado por la precocidad del diagnóstico, es primordial conocer sus formas de presentación clínica. Además, es muy relevante conocer aquellas lesiones cutáneas que pueden simular clínicamente un MM. El objetivo de este trabajo es describir las características morfológicas del MM y entregar una descripción breve de sus simuladores.

Pigmented skin lesions are common in the daily practice of a physician. Since the differential diagnosis includes Malignant Melanoma (MM) and considering that its prognosis is determined by the precocity of the diagnosis, is essential to know its different clinical features. In addition, its critical to know how to identify MM simulators. Theaim of this work, is to briefly describe the clinical spectrum of MM and its most frequent simulators.

Nevo de Reed (nevo de células fusiformes): relato de três casos com padrões dermatoscópicos distintos / Reed nevus (pigmented spindle-cell nevus): a report of three cases with distinct dermoscopic patterns

O nevo de Reed ou nevo de células fusiformes pigmentado pode ser um simulador do melanoma cutâneo. Apresenta, entretanto, diferentes características dermatoscópicas e histopatológicas. Trata-se de relato de três pacientes com apresentações clínicas, dermatoscópicas e histopatológicas distintas, correlacionando-as no auxílio diagnóstico deste com o melanoma e nevo de Sptiz.

Reed nevus or pigmented spindle-cell nevus may mimic cutaneous melanoma; however, its dermoscopic and histopathological characteristics are different. This case report describes three patients with distinct clinical, dermoscopic and histopathological presentations, which were correlated to enable a differential diagnosis to be made between melanoma and Spitz nevus.

Nevo de reed: lesão melanocítica benigna com feições malígnas / Nevus of reed: benign melanocytic lesion with malignant features

Este estudo apresenta achados microscópicos do nevo pigmentado de células fusiformes, designado como nevo de Reed, os quais resultaram de exames microscópicos realizados em múltiplos cortes de lesão de pele. Apresenta ainda a revisão de literatura pertinente. Os achados clínicos e microscópicos são consistentes com os dados da literatura descritos, originariamente, por Reed e colaboradores. O nevo de Reed é uma lesão melanocítica benigna, que, no entanto, pode ser equivocadamente identificada como um melanoma malígno. As lesões melanocíticas que podem ser confundidas com melanoma malígno devem ser avaliadas cuidadosamente, a fim de obter-se um diagnóstico acurado, e seguir-se a conduta pertinente.

This paper presents the findings of microscopic studies of the PigmentedSpindle-cell Nevus, called Nevus of Reed, carried on multiple sections of skin lesion. It presents, as well, a review of the related literature. The clinical andmicroscopic findings coincide with those originally described by Reed andcolleagues. The Nevus of Reed is a benign melanocytic lesion, which, however,can be easily misdiagnosed as a malignant melanoma. Therefore, in case of suchlesions, all efforts should be made to render an accurate diagnosis, and thus, toprovide the adequate therapy.