Acute Post-Traumatic Locked Knee - An Unmasking of a Rare Knee Disorder

@#Locked knees are commonly caused by meniscal tears, floating osteochondral bodies, ruptured anterior cruciate ligament (ACL) stump, or other mechanical origins in the knee. Some locked knees occur spontaneously, while in most cases, by a preceding knee trauma. Locked knees are rarely caused by a pathological growth in the knee. More unusually is the occurrence of locked knee caused by a pre-existing pathological entity after a traumatic event. We report a rare case of locking in the knee by a pre-existing knee condition presented only after trauma to the knee. This case emphasizes that locking in the knee can be caused by a pathology that may be asymptomatic until it is revealed by a traumatic event.

Correlation between cold pain of knee joint and subchondral bone marrow edema in patients with knee osteoarthritis / 中国骨伤

OBJECTIVE@#To investigate relationship between cold pain of knee joint and subchondral bone marrow edema (BME).@*METHODS@#From May 2018 to August 2019, 92 patients with knee osteoarthritis (KOA) associated with cold pain of knee were admitted, all patients were underwent MRI examination. The patients were divided into observation group (47 patients with BME) and control group(45 patients without BME). In observation group, there were 6 males and 41 females aged from 36 to 87 years old with an average of (63.2±12.3) years old. In control group, there were 10 males and 35 females, aged from 48 to 84 years old with an average of (62.7±8.3) years old. All patientswere treated with drugs. The degree of joint degeneration was evaluated by Kellgren-Lawrence (K-L) grading. Degree of cold pain of knee was evaluated by knee cold pain score, and degree of BME was evaluated according to WORMS. The correlation between cold pain of knee and K-L grading and BME was analyzed.@*RESULTS@#Score of cold pain in observation group (15.55±7.68) was higher than that of control group (9.42± 5.50), which had significant difference (@*CONCLUSION@#The cold pain of KOA patients is not related to K-L grading, but corelate with BME grading. The Cold pain of knee was more pronounced in KOA patients with BME, and the severity of BME is often related to degree of cold pain. It seemed to be a tendency:the more serious BME, the heavier coldpain.

The Effects of Physical Exercise on Pain Management in Patients with Knee Osteoarthritis: A Systematic Review with Metanalysis / Os efeitos do exercício físico sobre o manejo da dor em pacientes com osteoartrose de joelho: Uma revisão sistemática com meta-análise

Abstract Objective The present study verified, through a systematic review with meta-analysis, the effects of a rehabilitation, physical training program for the treatment of pain and muscle strength in knee osteoarthritis (OA). Methods We analyzed studies published between 2008 and 2018 referenced at the Medline (National Library of Medicine) database, selecting 7 randomized controlled clinical trials about exercise programs to improve pain and muscle strength in patients with knee OA with Physiotherapy Evidence Database (PeDro) score higher than 8. The Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) systematization was used to prepare this review, and a meta-analysis was carried out to obtain mathematical evidence the outcomes of physical exercise on pain. Results The studies included in the analysis contained a total of 934 participants aged 40 to 73 years-old, with 34.90% males. Most of the exercise sets offered in OA treatment had a significantly positive outcome result in both criteria, but mainly for pain relief (statistically significant difference, p< 0.003). Conclusion We infer that there was an improvement of pain in all articles that performed muscle strengthening, but there is still an obstacle to the protocols used.

Resumo Objetivo O presente estudo verificou por meio de uma revisão sistemática com metanálise os efeitos de um programa de reabilitação, através de um programa de treinamento físico, para o tratamento da dor e força muscular na osteoartrose (OA) de joelho. Métodos Foram analisados os estudos publicados entre 2008 e 2018, tendo como referência a base de dados Medline (National Library of Medicine), da qual foram selecionados 7 ensaios clínicos controlados randomizados que pontuaram acima de 8 na escala Physiotherapy Evidence Database (PeDro, na sigla em inglês), sobre programas de exercícios na melhora da dor e força muscular em paciente com OA de joelho. Foi usada a sistematização Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA, na sigla em inglês) para a elaboração desta revisão e a realização de uma metanálise com o objetivo de evidenciar matematicamente os resultados do exercício físico sobre a dor. Resultados Os estudos incluídos na análise continham um total de 934 participantes com idade entre 40 a 73 anos, sendo que 34,90% desses eram do sexo masculino. A maioria dos conjuntos de exercícios oferecidos no tratamento da OA tiveram resultado significativamente positivo em ambos os quesitos, mas principalmente para o alívio da dor (estatisticamente significativo p< 0, 003). Conclusão Inferimos que houve uma melhora da dor em todos os artigos que realizaram fortalecimento muscular, porém ainda há um óbice sobre os protocolos utilizados.

Intra-articular injection of hyaluronic acid versus platelet-rich plasma in the treatment of knee osteoarthritis / 中国组织工程研究

BACKGROUND: Platelet-rich plasma contains a variety of growth factors that can promote tissue repair and regeneration. Therefore, it has been gradually used in the clinical treatment of osteoarthritis. Sodium hyaluronate can improve inflammatory responses in synovial tissue, protect the articular cartilage, promote the healing and regeneration of articular cartilage, and relieve pain. OBJECTIVE: To compare the improvement of pain and function in knee osteoarthritis patients after treatment with platelet-rich plasma and sodium hyaluronate. METHODS: Patients who met the inclusion criteria were randomly assigned to a platelet-rich plasma treatment group and a sodium hyaluronate treatment group. Patients in the platelet-rich plasma group received three injections of platelet-rich plasma via arthrocentesis within 21 days, and those in the sodium hyaluronate group received five injections of sodium hyaluronate via arthrocentesis within 35 days. Pain relief and functional improvement were assessed before and 2,4, 6 months after injection using the Visual Analogue Scale, the Knee injury and Osteoarthritis Outcome System, and the Hospital for Special Surgery scores. RESULTS AND CONCLUSION: During the follow-up visit, 35 patients in the platelet-rich plasma group and 36 patients in the sodium hyaluronate group were enrolled in the result analysis. At the end of 6-month follow-up, pain and functional symptoms were certainly relieved in both two groups. For grade II knee osteoarthritis, platelet-rich plasma injection showed better outcomes than sodium hyaluronate injection. After first injection, the Visual Analogue Scale scores in the platelet-rich plasma group were lowered by 50% from the initial values. No significant differences in the Hospital for Special Surgery score were observed between the two groups at 2, 4, and 6 months after treatment (F>0.05). Therefore, platelet-rich plasma therapy is appropriate for low-grade knee osteoarthritis.

Effect of Addition and Subtraction Therapy of Xuanbitang on Acute Inflammation Caused by Knee Osteoarthritis of Rheumatic Fever Arthralgia Type at Attack Stage / 中国实验方剂学杂志

Objective:To observe the controlling effect of addition and subtraction therapy of Xuanbi tang on knee osteoarthritis of rheumatic fever arthralgia type (KOA) at attack stage and to investigate the influence to acute inflammation factors. Method:One hundred and twenty-eight patients were randomly divided into control group and observation group (1∶1) by random number table with SAS software. The patients in both groups got celecoxib capsules, 0.2 g/time, 1 time/day, glucosamine hydrochloride capsule, 1 grain/time, 2 times/day. Patients in control group addiiontally got Simiaowan, 6 g/time, 2 times/day. Patients in observation group got addition and subtraction therapy of Xuanbitang, 1 dose/day, with a treatment course of 2 weeks in both groups. Visual analogue scale of pain (VAS) was used to discuss pain degree of knee joint, and the VAS scores during activity and resting state were recorded every day, and the time to pain relief and time to pain disappearance were also recorded. Before and after treatment, the scores of osteoarthritis index visual scale of Western Ontario and McMaster University (WOMAC), scores of swelling degree and scores of rheumatism heat arthralgia syndrome were graded. The levels of high sensitive C-reactive protein (hs CRP), interleukin-1β (IL-1β), interleukin-6 (IL-6), tumor necrosis factor-α (TNF-α) and serum matrix metalloproteinase-3 (MMP-3) were detected before and after treatment. In addition, safety was evaluated and discussed. Result:The comprehensive total effective rate in observation group was 95.00% (57/60), higher than 83.05% (49/59) in control group (P<0.05). At the third, seventh, tenth, fourteenth day after treatment, scores of knee joint pain degree in observation group were lower than those in control group (P<0.01). Time to pain relief and time to pain disappearance were shorter than those in control group (P<0.01). Scores of WOMAC, swelling degree and rheumatism heat arthralgia syndrome were all lower than those in control group (P<0.01). Levels of hs-CRP, IL-1β, IL-6, TNF-α and MMP-3 were lower than those in control group (P<0.01). In addition, there was no adverse reaction related to Xuanbitang. Conclusion:Addition and subtraction therapy of Xuanbitang can relieve pain, swelling and other symptoms, improve knee joint function, shorten the course of disease, and control the acute inflammatory reaction, with significant clinical efficacy and safety.

Open quadricepsplasty in hyperextension deformity of knee in children with arthrogryposis

Arthrogryposis includes heterogeneous disorders, characterized by congenital contractures of multiple joints. Knee involvement is very common (38–90 % of patients with amyoplasia) ranging from soft-tissue contractures (in flexion or hyperextension) to subluxation and dislocation. Children who present late will require surgery involving quadricepsplasty or lengthening of the contracted quadriceps muscle. Curtis and Fisher describe an open V-Y lengthening of the quadriceps femoris with post-operative immobilization in 30-45 ° of flexion. The main issue of this technique was limited degree of flexion that can be achieved, and the fibrous replacement of the quadriceps muscle. This is a neglected case of hyperextension deformity and congenital dislocation of knee in children with arthrogryposis resistant to conservative management and successfully treated by open quadricepsplasty.

Effect of posterior oblique ligament repair on rotational stability of knee joint / 中国修复重建外科杂志

Objective: To investigate effect of posterior oblique ligament (POL) repair on the rotational stability of the knee joint for the medial collateral ligament (MCL) combined with anterior cruciate ligament (ACL) ruptures. Methods: The clinical data of 50 patients (50 knees) with grade-3 MCL-ACL combined injuries who met the selection criteria between January 2013 and December 2015 were retrospectively analyzed. All ACLs were reconstructed with autogenous tendon and the superficial and deep layers of MCLs were sutured; then, POLs were also sutured in 25 patients of repair group and only received conservation treatment postoperatively in 25 patients of conservation group. There was no significant difference in gender, age, disease duration, and preoperative KT-1000 measuring, medial joint space opening, International Knee Documentation Committee (IKDC) score, visual analogue scale (VAS) score, and knee range of motion between the two groups ( P>0.05). Results: All incisions of the two groups healed by first intention, no surgical related complications occurred. All patients were followed up, with follow-up time of 28-56 months (mean, 38.1 months) in repair group and 26-55 months (mean, 29.1 months) in conservation group. At last follow-up, the IKDC score, VAS score, KT-1000 measuring, medial joint space opening, and knee range of motion significantly improved in the two groups when compared with preoperative ones ( P0.05). The Slocum test showed that there was no instability of the anterior medial rotation in the two groups. Conclusion: The POL repair can't obtain more medial stability after ACL reconstruction and MCL repair (superficial and deep layers) for patients who have MCL-ACL combined injuries.

Dilemma in Chronic Extrusion of Medial Meniscus with Unicompartmental Osteoarthritis in Middle Aged: A Case Report

Abstract@#Medial meniscus root tear (MMRT) is uncommon and is often associated with osteoarthritis during presentation. Whether it is a cause or effect, it is still debatable at this point of time. However, when a combination of injuries occurs in a middle age group patient, a careful examination before offering a treatment is advised. We herein report a case of a middle-aged gentleman suffering from both arthritis and MMRT.

Comparasion of clinical outcomes of reconstruction by LARS and conservative treatment for patients older than 50 years with chronic forward instability of knee joint / 中国综合临床

Objective To compare the outcomes between conservative treatment and reconstruction with LARS in patients over 50 years old with chronic forward instability of knee joint.Methods Forty patients with chronic forward instability of knee joint from May,2005 to September,2013 in Shengjing Hospital of China Medical University were included in this study and were divided into conservative treatment group(16 cases) and LARS group(19 cases) besides that were ineligible according to different treatment methods.All patients were followed up for two years.The evaluation indicators included Lysholm,IKDC,Tegner,ROM,Kneelax and Kellgren-Lawrence rating.Results At the end of two-year follow-up,the knee joint function score of conservative treatment group was significantly higher than that before treatment (Lysholm score after treatment (83.4± 12.5) points,before treatment (69.6 ± 10.4) points,t =-11.502,P =0.00;IKDC after treatment,abnormal 2 cases,and before treatment,abnormal 10 cases,P =0.00;Tegner after treatment 6 (1,9) points,before treatment 3 (1,5) points,Z =-3.471,P =0.01).The knee joint function score and Kneelax measurement in the LARS ligament reconstruction group were significantly improved after operation(Lysholm score after treatment (80.0±14.2) points,before treatment (68.7±9.6) points,t =-7.875,P =0.00;IKDC score after treatment,abnormal 2 cases,and before treatment,abnormal 13 cases,P =0.00;Tegener score after treatment 8 (1,9) points,before treatment 3 (1,5) points,Z =-3.879,P=0.00;Kneelax score after treatment (1.5 ± 0.8) mm,before treatment (4.2 ± 0.8) mm,t =9.955,P =0.00).At the end of two-year follow-up,kneelax and Tegner scores in LARS ligament reconstruction group were significantly higher than those in conservative treatment group (Z =6.109,P=0.00;Z =2.672,P =0.01).Conclusion Compared with conservative treatment,LARS ligament reconstruction is more conducive to the stability and functional recovery of knee joint in patients over 50 years old with chronic anterior instability of knee joint.

A Comparative Clinical Study To Evaluate The Efficacy Of Janubasti Followed By Patrapinda Sweda And Janubasti Followed By Atasi Upanaha Sweda In Janu Sandhigata Vata W.s.r To Osteoarthritis Of Knee Joint

Janu Sandhigata Vata is a common Vata predominant disorder mainly caused in Vriddhavastha. It is a degenerative articular disorder caused in geriatric age group and its correlates with Osteoarthritis of knee joint. Being commonest form of articular disorders, Osteoarthritis poses a huge hindrance in day to day activities of the sufferer like walking, dressing and bathing etc. Due to Vriddaavasta, Uttarothara Dhatuposhana gets reduced and finally makes the person lame. Hence this study was conducted on 10 patients for 7 days to evaluate the efficacy of Janubasti with Moorchita Tila Taila followed by Patrapinda Sweda in Group A and Janubasti with Moorchita Tila Taila followed by Atasi Upanaha Sweda in Group B. The study reports significant relief in subjective parameters like Vatapurna Dritisparsha (joint crepitations), Sandhi Shoola (joint pain) and Prasarana akunchana pravriti sa vedana (pain during flexion and extension of joint) Sandhi Shotha (joint swelling) is completely relieved after the study. Assessment of results was done on the subjective parameters which showed highly significant changes in Vatapurna Drithisparsha, Sandhi Shotha and Prasarana Akunchana Vedana, and significant improvement in Sandhi Shoola in Group A. In group B Vatapurna Drithisparsha, Sandhi Shotha and Sandhi Shoola showed highly significant changes and Prasarana Akunchana Vedana showed significant changes.

The therapeutic effects of Yougui pill on knee osteoarthritis and the expression of Wnt signal pathway related factors in rats / 中国应用生理学杂志

OBJECTIVES@#To observe the effects of Yougui pill (Traditional Chinese Medicine) on the related factors of Wnt signal pathway of rats with knee osteoarthritis (KOA), and explore its protective mechanism.@*METHODS@#Sixty SPF SD rats were randomly divided into the sham-operative group, model group, glucosamine sulfate group, high-dose, middle-dose, low-dose of Yougui pill treated group (=10). KOA model was established by modified Hulth method for six weeks. The rats in the high, middle and low-dose of Yougui pill group were treated with Yougui pills at the doses of 20,10 and 5 g/kg respectively by gastrogavage once a day for 8 weeks, while equal volume of normal saline was given to those in the sham and model control group and an equal volume of glucosamine sulfate (1.7 g/kg·d) was given to those in glucosamine sulfate group for 8 weeks. The knee joint was removed after the last dose of drug. The pathological changes of cartilaginous tissues were observed under a microscope. The mRNA levels of Dickkopf homolog 1(DKK1), Wnt induced secreted protein 1(WISP1), Wnt1, low density lipoprotein receptor related protein 5(LRP5) and beta -catenin in rats cartilaginous tissues were analyzed by using RT-PCR method, and the protein contents of DKK1, WISP1, Wnt1, LRP5 and beta-catenin in cartilaginous tissues were detected by Western blot.@*RESULTS@#Compared with the sham group, the articular cartilage was severely damaged, the Mankin score was increased significantly (<0. 05), the mRNA and protein expression levels of DKK1 in cartilaginous tissue were markedly decreased(<0.05), while those of WISP, Wnt1, LRP5 and beta-catenin were increased significantly in model group(<0.05). Compared with model group, the articular cartilage lesions was light (<0.05), the Mankin Score was decreased significantly(<0.05), and the mRNA and protein levels of DKK1 in cartilaginous tissue were increased(<0.05), while those of WISP, Wnt1, LRP5 and beta-catenin were decreased in Yougui pill high-dose group and glucosamine sulfate group (<0.05).@*CONCLUSIONS@#Yougui pill has protective effects on the KOA by inhibiting the expressions of WISP, Wnt1, LRP5, beta-catenin and increasing the expression of DKK1 cytokine in the Wnt signaling pathway.

Effectiveness of medial open wedge high tibial osteotomy combined with posterior slope angle of tibial plateau correction in treatment of osteoarthritis of limited flexion knee with varus deformity / 中国修复重建外科杂志

Objective: To explore the short-term effectiveness of medial open wedge high tibial osteotomy (OWHTO) combined with posterior slope angle of tibial plateau correction to treat the osteoarthritis of limited flexion knee with varus deformity.

Effectiveness of open wedge high tibial osteotomy on medial unicompartmental knee osteoarthritis / 中国修复重建外科杂志

Objective: To evaluate the effectiveness of open wedge high tibial osteotomy (OWHTO) in treatment of medial unicompartmental knee osteoarthritis (MUKOA). Methods: A clinical data of 61 cases with MUKOA who were treated with OWHTO between January 2015 and January 2017 were retrospectively analyzed. There are 14 males and 47 females with an average age of 52.8 years (mean, 44-60 years). The body mass index ranged from 19.1 to 34.7 kg/m 2 (mean, 25.3 kg/m 2). Twenty-seven cases were left side and 34 cases were right side. The disease duration was 1-9 years (mean, 5.3 years). The MUKOA was rated as stage Ⅱ in 33 cases and stage Ⅲ in 28 cases. Preoperative Hospital for Special Surgery (HSS) score was 56.0±3.7. Walking visual analogue scale (VAS) score was 4.6±1.0. Results: The operation time was 49-85 minutes (mean, 66.5 minutes). The length of incision was 10-13 cm (mean, 11.0 cm). The total overt blood loss was 80-210 mL (mean, 139.1 mL). The postoperative bed-rest time was 1-10 days (mean, 4.7 days). All patients were followed up 12-24 months (mean, 17.3 months). The bearing area of tibial platform at 3 months after operation was 60.3%-66.8%, with an average of 63.4%. At 3 and 6 months after operation, the HSS score was 79.1±4.2 and 85.3±3.1 respectively, and the VAS score was 1.7±0.7 and 0.6±0.5 respectively, all showing significant differences ( P<0.05). Conclusion: OWHTO is an ideal choice for treating MUKOA with less postoperative complications. The force line could be corrected by OWHTO. However, the preoperative preparations are very important, especially that the open angle should be measured accurately.

A clinical application of magnetic resonance imaging combined with the diagnosis of bone scanning in bone tumors of knee / 中国医学装备

Objective: To investigate the clinical value of magnetic resonance imaging (MRI) combined with the diagnosis of bone scanning in bone tumors of knee. Methods: 70 patients with bone tumor of knee were enrolled in the research. And all of them were divided into MRI group (37 cases), bone scanning group (14 cases) and combined detection group (19 cases) according to different imageological examination mode when they were hospitalized. These images of imageological examination and pathological results were collected, and lesion property, lesion boundary, lesion range, invasiveness of lesion and homogeneousness of lesion interior in the images were analyzed and researched. The diagnostic values of various examination technique for bone tumor of knee were compared. Results:The diagnostic accordance rates of benign and malignant bone tumor of knee in the combined group were 100% and 92.86%, and they were 76.4% and 70% in MRI group, and they were 57.14% and 85.71% in bone scanning group. And the difference of diagnostic accordance rate between MRI group and bone scanning group was not significant (x2=2.336, P>0.05). The differences of diagnostic accordance rates of benign and malignant bone tumor of knee between MRI group and combined detection group were significant (x2=2.936, x2=3.524, P<0.05), respectively. And the diagnostic accordance rates of benign and malignant bone tumor of knee between bone scanning group and combined detection group also were significant (x2=3.718, x2=2.947, P<0.05), respectively. Besides, the differences of lesion boundary, lesion range and homogeneousness of lesion interior among the three group were significant (x2=4.001, x2=3.695, x2=2.852, P<0.05), respectively. Conclusion: The combination of MRI and bone scanning examination can partially increase the diagnostic efficiency at early stage for bone tumor of knee, and provide more comprehensive and more reliable image data for clinical practice. Therefore, it is beneficial to improve the prognosis of patients and it has higher application value in clinical practice.

Improvement Effects of Drink Containing Ampelopsis glandulosa Extract on Knee Joint Discomfort / 日本補完代替医療学会誌

The prevalence of joint diseases in Japan is increasing yearly and it causes the need of nursing care and reduces quality of life. Therefore, there is an urgent need for the development of approaches to prevent and treat the diseases. In the present study, we investigated the effective, healthy food material focusing on the metabolism of joint cartilage. Ampelopsis glandulosa (A. g. ) extract improved exacerbation of hyaluronic acid metabolism and NFκB nuclear translocation caused by inflammatory cytokines, and it suppressed the onset of collagen-induced arthritis in mice. Moreover, intake of the drink containing A. g. extract for three months improved discomfort, pain, and bending angle of knee joint in activities of daily living. These results suggest that A. g. extract improves hyaluronic acid metabolism of joint cartilage, and it is expected to prevent and improve joint disease by long-term intake of the drink containing A. g. extract.

Protocolo de Investigación: Validación de Resonancia Magnética en Meniscopatías Comparado con Artroscopía. Pacientes de Traumatología del Hospital de Especialidades José Carrasco Arteaga. Cuenca - Ecuador. 2016-2017 / Research Protocol: Validation of Magnetic Resonance Imaging for Meniscal Injuries Compared with Arthroscopy. Trauma Patients of the Specialty Hospital José Carrasco Arteaga. Ecuador basin. 2016-2017

INTRODUCCIÓN: La resonancia magnética es un método de imagen no invasivo que valora satisfactoriamente las meniscopatías, contribuyendo significativamente a su diagnóstico y evitando la realización de artroscopias innecesarias. El objetivo es determinar la validez del estudio de RM para el diagnóstico de las meniscopatías en comparación con la artroscopía, en pacientes del servicio de traumatología del Hospital de Especialidades José Carrasco Arteaga de Cuenca-Ecuador, entre Abril 2016 y Marzo 2017. METODOLOGÍA: Es un estudio de prueba diagnóstica, y evalúa los pacientes con diagnóstico clínico de meniscopatía, tratados en el servicio de traumatología del hospital, durante el periodo Abril 2016 a Marzo 2017. Los hallazgos de la RM serán contrastados con la exploración artroscópica posterior, la información será recogida mediante un formulario. El análisis estadístico se utiliza el Chi2 para establecer asociación entre variables y tablas de doble entrada para validar pruebas diagnósticas, con nivel de seguridad del 95 %, mediante el software estadístico SPSS. RESULTADOS ESPERADOS: Existe mayor validez diagnóstica del estudio de RM para el diagnóstico de las meniscopatías, comparado con la artroscopia.(au)

INTRODUCTION: Magnetic Resonance Imaging is a noninvasive imaging method that satisfactorily evaluates meniscal injuries, significantly contributing to its diagnosis and avoiding unnecessary arthroscopies. The aim determine the validity of the MRI study for the diagnosis of meniscal injuries compared to arthroscopy in patients from the traumatology service of the Hospital of Specialties Jose Carrasco Arteaga of Cuenca - Ecuador between April 2016 and March 2017. METHODOLOGY: Validation study of a diagnostic test, evaluated the patients with clinical diagnosis of meniscal injuries, treated in the traumatology service of the hospital, period from April 2016 to March 2017. The findings of the MRI of contrasting with the exploration posterior arthroscopy, this information will be collected through a form. The statistical analysis, Chi2 used to establish an association between variables and double-entry tables to validate diagnostic tests, with a 95 % safety level, using SPSS statistical software. EXPECTED RESULTS: There is greater diagnostic validity of the MRI study for the diagnosis of meniscopathies compared to arthroscopy(au)

Effect of bone peptide injection in patients with osteoarthritis of the activity of alkaline phosphatase / 中国生化药物杂志

Objective To analyze the effect of bone peptide injection in patients with osteoarthritis of the activity of alkaline phosphatase. Methods A total of 74 patients with osteoarthritis of the bone were selected from March 2015 to May 2017 in our hospital and were randomly divided into two groups,with 37 cases in each group.The control group was treated with glucosamine sulfate, the observation group was treated with ossotide injection.The therapeutic effect and alkaline phosphatase activity were compared between two groups. Results The total effective rate was 97.30% in the observation group, which was significantly higher than that in the control group (70.27%) (P<0.05) .The score of knee function was (79.62±5.80) in the observation group.which was significantly higher than that in the control group (71.06±5.41) (P<0.05).The alkaline phosphatase activity after the treatment of 30d and 45d (0.97±0.12), nkat/L (1.39±0.12) nkat /L was significantly higher than the control group (0.71±0.10), nkat/L, (0.88±0.10) nkat/L, the incidence rate of adverse reaction(5.41 %) was significantly lower than the control group (24.32 %) (P<0.05). Conclusion Bone peptide injection has significant therapeutic effect on bone and joint osteoarthritis, can effectively improve the knee joint function of the patients, improve the patients with alkaline phosphatase activity, and high safety, is worthy of promotion.

Effect of bone peptide injection in patients with osteoarthritis of the activity of alkaline phosphatase / 中国生化药物杂志

Objective To analyze the effect of bone peptide injection in patients with osteoarthritis of the activity of alkaline phosphatase. Methods A total of 74 patients with osteoarthritis of the bone were selected from March 2015 to May 2017 in our hospital and were randomly divided into two groups,with 37 cases in each group.The control group was treated with glucosamine sulfate, the observation group was treated with ossotide injection.The therapeutic effect and alkaline phosphatase activity were compared between two groups. Results The total effective rate was 97.30% in the observation group, which was significantly higher than that in the control group (70.27%) (P<0.05) .The score of knee function was (79.62±5.80) in the observation group.which was significantly higher than that in the control group (71.06±5.41) (P<0.05).The alkaline phosphatase activity after the treatment of 30d and 45d (0.97±0.12), nkat/L (1.39±0.12) nkat /L was significantly higher than the control group (0.71±0.10), nkat/L, (0.88±0.10) nkat/L, the incidence rate of adverse reaction(5.41 %) was significantly lower than the control group (24.32 %) (P<0.05). Conclusion Bone peptide injection has significant therapeutic effect on bone and joint osteoarthritis, can effectively improve the knee joint function of the patients, improve the patients with alkaline phosphatase activity, and high safety, is worthy of promotion.

Clinical Observation of Qizhi Qushi Jianpi Prescription in the Treatment of Chronic Synovitis of Knee Joint in Middleaged and Elderly Patients after Debridement under Arthroscope / 中国药房

OBJECTIVE:To observe clinical efficacy and safety of Qizhi qushi jianpi prescription in the treatment of chronic synovitis of knee joint in middleaged and elderly patients after debridement under arthroscope. METHODS:A total of 80 mid-dleaged and elderly inpatients with chronic synovitis of knee joint were selected and randomly divided into treatment group and con-trol group,with 40 cases in each group. Clinical efficacy,VAS,swelling score of modified Cincinnati knee joint score system, Lysholm score of knee joint function,the occurrence of ADR were observed in 2 groups. RESULTS:Total effective rate of treat-ment group(92.5%)was significantly than that of control group(77.5%),with statistical significance(P0.05). On the first day after surgery,VAS score of 2 groups decreased significantly,and there was statistical signifi-cance compared to before surgery (P<0.05). One month after surgery,VAS score of 2 groups decreased significantly,and the treatment group was significantly lower than the control group,with statistical significance(P<0.05). Swelling score of knee joint 1 month after surgery and Lysholm score 3 months after surgery increased significantly in 2 groups,and the treatment group was significantly higher than the control group,with statistical significance(P<0.05). 5 patients of treatment group suffered from stom-ach discomfort,and the symptom was relieved after adding the ingredient of comforting stomach and removing dampness through diuresis. CONCLUSIONS:Qizhi qushi jianpi prescription is effective for chronic synovitis of knee joint in middleaged and elderly patients after debridement under arthroscope,and can relieve pain, remove swelling and recover knee joint function with good safety.

Clinical Study on Oral Administration and External Application of Yanyuxiao on Acute Traumatic Synovitis of Knee Joint / 中国中医药信息杂志

Objective To observe the clinical efficacy of oral administration and external application of Yanyuxiao on acute traumatic synovitis of knee joint. Methods Totally 86 patients with acute traumatic synovitis of knee joint were randomly divided into treatment group and control group, with 43 cases in each group. The patients in the two groups were treated with conventional western medicine. Patients in the control group orally took diclofenac sodium at the same time, while patients in the treatment group received oral administration and external application of Yanyuxiao Formula for 2 weeks. The scores of pain, swelling and function of knee joint and the levels interleukin-6 (IL-6) and tumor necrosis factor-α (TNF-α) of joint fluid before and after the treatment were observed. The efficacy and the recurrence rate in three months after treatment were compared. Results The scores of pain, swelling and function of knee joint of the two groups significantly decreased after treatment, and the scores of pain, swelling and function of knee joint of the treatment group in one and two weeks were lower than those of the control group (P<0.05, P<0.01). The levels of synovial fluid IL-6 and TNF-α of the treatment group were lower than those of the control group after two-week treatment (P<0.01); the total effective rate was higher than that of the control group (P<0.05). The recurrence rate of the treatment group was lower than that of the control group after discharged for 3 months (P<0.05). There were no obvious adverse reactions during the treatment period. Conclusion Oral administration and external application of Yanyuxiao Formula has definite efficacy for acute traumatic synovitis of knee joint, with good safety.