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Acta Academiae Medicinae Sinicae ; (6): 244-252, 2022.
Article Dans Chinois | WPRIM | ID: wpr-927872

Résumé

Objective To explore the performance and mechanism of(+)-corynoline in treating triple negative breast cancer MDA-MB-436 cells and thus provide an option for the development of drugs against this cancer. Methods The viability,proliferation,apoptosis and migration/invasion of MDA-MB-436 cells treated with(+)-corynoline were detected by CCK-8 assay,colony formation assay,flow cytometry and Transwell assay,respectively.Furthermore,Western blotting was employed to determine the expression of related proteins,and RNA-Seq was performed for the MDA-MB-436 cells treated with(+)-corynoline. Results (+)-corynoline inhibited the proliferation and stemness and promoted the apoptosis of MDA-MB-436 cells.Further,(+)-corynoline may activate the oxidative phosphorylation pathway to play a role in inhibiting triple negative breast cancer. Conclusion (+)-corynoline can inhibit triple negative breast cancer cells,which helps to address the poor efficacy of existing chemotherapeutics and facilitate the development of drugs against this cancer.


Sujets)
Femelle , Humains , Apoptose , Alcaloïdes de type berbérine , Tumeurs du sein , Lignée cellulaire tumorale , Mouvement cellulaire , Prolifération cellulaire , Tumeurs du sein triple-négatives/métabolisme
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