Résumé
@#AIM: To analyze the changes in serum and aqueous humor of patients with diabetic cataracts in vitamin C, oxidative stress products, inflammatory factors and vascular endothelial growth factor(VEGF)levels.<p>METHODS: From January 2018 to December 2019, 40 patients with diabetic cataract(40 eyes)were selected as the observation group, and 40 patients with simple cataract(40 eyes)were selected as the control group. The differences in the levels of vitamin C, oxidative stress products(malondialdehyde), inflammatory factors(IL-6 and IL-8)and VEGF in blood and aqueous humor samples of the two groups of patients were analyzed. <p>RESULTS: There was no difference in serum vitamin C levels between the two groups(<i>P</i>>0.05), but the aqueous vitamin C levels in the observation group were significantly lower than those in the control group(20.6±13.6mg/L <i>vs</i> 27.2±9.9mg/L, <i>P</i><0.05); There was no difference in the serum malondialdehyde level of patients(<i>P</i>>0.05), but the aqueous malondialdehyde level of the observation group was significantly higher than that of the control group(12.6±4.6nmol/mL <i>vs</i> 8.0±3.1nmol/mL,<i> P</i><0.001); Serum and aqueous humor IL-6 and IL-8 levels were significantly higher than those of the control group(<i>P</i><0.001); there was no difference in serum VEGF levels between the two groups(<i>P</i>>0.05), but the observation group's aqueous humor VEGF levels were significantly higher than the control group(45.6±20.6pg/mL <i>vs</i> 16.5±4.5pg/mL, <i>P</i><0.001).<p>CONCLUSION: Compared with patients with simple cataract, patients with diabetic cataract have similar serum vitamin C, oxidative stress products and VEGF levels, but there are greater differences in the levels of vitamin C, oxidative stress products and VEGF in their aqueous humor. At the same time, patients with diabetic cataracts serum and aqueous humor inflammatory factor levels are higher than those of patients with simple cataract.
Résumé
Objective To explore effect of propofol or sevoflurane combined with dexmedetomidine on postoperative cognitive function , erythrocyte sedimentation rate and oxidative stress in patients with bone tumour .Methods 52 cases with bone tumor and requiring a surgery were selected and divided into sevoflurane group and propofol group randomly.The sevoflurane group were anesthetized with sevoflurane and dexmedetomidine.Propofol group were anesthetized with propofol and dexmedetomidine.The cognitive function score, recovery time, sedimentation value and oxidative stress level were compared after operation.ResuIts Compared with propofol group at the same time, the cognitive function score of patients in sevoflurane group at postoperative 6, 12, 24 h were higher (P<0.05) and restored to preoperative levels at postoperative 24 h (P<0.05) .The recovery time of spontaneous breathing, eyes open, remove endotracheal intubation and directional force in sevoflurane group were shorter than that in propofol group (P<0.05).Compared with propofol group at the same time, the erythrocyte sedimentation rate in sevoflurane group at postoperative 5, 10d were lower (P<0.05) and restored to preoperative levels at postoperative 10 d (P<0.05).Compared with propofol group postoperation, the superoxide dismutase (SOD) and methane dicarboxylic aldehyde (MDA) levels in sevoflurane group were lower, total antioxidant capacity (T-AOC) level was higher (P<0.05).ConcIusion Sevoflurane has a smaller effect on postoperative cognitive function than propofol in patients with bone tumor, combined with dexmedetomidine, which has an important significance to clinical surgery.