Inhibitory effect of breviscapine on primary cultural calf pulmonary artery smooth muscle cell proliferotion / 中国药理学通报

AIM To explore the effect of breviscapine on primary cultural calf pulmonary artery smooth muscle cell (PASMC) proliferation. METHODS By primary cuture of calf PASMC, the effect of PASMC proliferation was analysed using MTT colorimetry, flow cytomerty, Giemsa staining. RESULTS Compared with control group, PASMC proliferations in breviscapine group was significantly inhibited from G 0/G 1 to S phases in the cell cycle. CONCLUSION Breviscapine could significantly inhibit PASMC profiferation. The mechanism for this may due to inhibition of protein kinase C.