Comparison of diagnostic performance of Clear Cell Likelihood Score v1.0 and v2.0 for clear renal cell carcinoma / 南方医科大学学报

OBJECTIVE@#To compare the performance of Clear Cell Likelihood Score (ccLS) v1.0 and v2.0 in diagnosing clear cell renal cell carcinoma (ccRCC) from small renal masses (SRM).@*METHODS@#We retrospectively analyzed the clinical data and MR images of patients with pathologically confirmed solid SRM from the First Medical Center of the Chinese PLA General Hospital between January 1, 2018, and December 31, 2021, and from Beijing Friendship Hospital of Capital Medical University and Peking University First Hospital between January 1, 2019 and May 17, 2021. Six abdominal radiologists were trained for use of the ccLS algorithm and scored independently using ccLS v1.0 and ccLS v2.0. Random- effects logistic regression modeling was used to generate plot receiver operating characteristic curves (ROC) to evaluate the diagnostic performance of ccLS v1.0 and ccLS v2.0 for ccRCC, and the area under curve (AUC) of these two scoring systems were compared using the DeLong's test. Weighted Kappa test was used to evaluate the interobserver agreement of the ccLS score, and differences in the weighted Kappa coefficients was compared using the Gwet consistency coefficient.@*RESULTS@#In total, 691 patients (491 males, 200 females; mean age, 54 ± 12 years) with 700 renal masses were included in this study. The pooled accuracy, sensitivity, specificity, positive predictive value (PPV), and negative predictive value (NPV) of ccLS v1.0 for diagnosing ccRCC were 77.1%, 76.8%, 77.7%, 90.2%, and 55.7%, as compared with 80.9%, 79.3%, 85.1%, 93.4%, 60.6% with ccLS v2.0, respectively. The AUC of ccLS v2.0 was significantly higher than that of ccLS v1.0 for diagnosis of ccRCC (0.897 vs 0.859; P < 0.01). The interobserver agreement did not differ significantly between ccLS v1.0 and ccLS v2.0 (0.56 vs 0.60; P > 0.05).@*CONCLUSION@#ccLS v2.0 has better performance for diagnosing ccRCC than ccLS v1.0 and can be considered for use to assist radiologists with their routine diagnostic tasks.

Nefrectomía parcial laparoscópica asistida por radiofrecuencia: una nueva alternativa en el tratamiento de masas renales pequeñas / Radiofrencuency assisted laparoscopic partial nephrectomy: a new alternative in the treatment of small renal masses

Introducción: Avances técnicos y la experiencia acumulada hacen que la nefrectomía parcial laparoscópica sea una opción viable en el tratamiento de masas renales pequeñas (<4 cm), debido a su efectividad oncológica y la asociación entre la nefrectomía radical y la insuficiencia renal crónica y la morbilidad cardiovascular asociada a ésta. Las terapias ablativas surgen como alternativa en el tratamiento de las masas renales pequeñas, entre éstas la radiofrecuencia. Reportes recientes sugieren que las terapias ablativas no ofrecen un adecuado control oncológico y que la imagenología actual no puede llevar a cabo seguimientos de forma segura. Material y método: presentamos una serie de casos de 13 pacientes portadores de 16 tumores renales, sometidos a nefrectomía parcial laparoscópica asistida por radiofrecuencia entre abril de 2008 y junio de 2009. El procedimiento fue realizado por vía transperitoneal en 11 pacientes y vía retroperitoneal en dos. La radiofrecuencia fue administrada por vía percutánea bajo control visual laparoscópico y la tumorectomía realizada sin necesidad de clampear los vasos renales. Resultados: el tiempo quirúrgico promedio fue de 93 mins. (45-135).No hubo sangrado importante intraoperatorio ni complicaciones postoperatorias. De 16 tumores, 13correspondieron a carcinoma de células renales, uno oncocitoma y uno angiomiolipoma. Los márgenes quirúrgicos fueron informados negativos y todos los pacientes están en remisión completa con un seguimiento promedio de 8 meses (1-15 meses). Conclusiones: la radiofrecuencia es una excelente ayuda a la nefrectomía parcial laparoscópica. Permite realizar el procedimiento sin clampear los vasos renales sometiendo parénquima renal sano a isquemia y con escaso sangrado.

Introduction: Technical advances and accumulated experience have done laparoscopic partial nephrectomy a viable option in the treatment of small renal masses (<4 cm), because of its oncologic effectiveness and the association between radical nephrectomy and chronic renal failure and cardiovascular morbidity associated. Ablative therapies arise like a valid alternative in the treatment of small renal masses, between these radiofrequency. Recent reports suggest that ablative therapies do not offer an adequate oncological control and that current imagenology can’t carry out follow-ups of sure form. Materials and methods: we present a case series of 13 patients diagnosed of 16 small renal masses, treated by laparoscopic partial nephrectomy with radiofrequency assistance between April 2008 and June 2009. Procedure was realized by a transperitoneal approach in eleven patients and by retroperitoneal approach in two. Radiofrequency was administrated by percutaneous way under visual laparoscopic control and partial nephrectomy realized without needing of renal vascular clamping. Average surgical time was 93 minutes (45-135). There was no important bleeding during surgery and no surgical complications associated. Thirteen of total sixteen tumors corresponded to renal cell carcinomas, one to angiomiolypoma and the last one to oncocytoma. All surgical margins were informed as negatives and at present, all the patients have no evidence of disease with a follow up average time of 8 months (1-15 months). Conclusions: radiofrequency can be an excellent tool assisting laparoscopic partial nephrectomy. It allows surgery without need of clamping renal vein and artery avoiding warm ischemia and with no bleeding.