Résumé
Objective To investigate the clinical value of tumor specific grow th factor(TSGF),neuron specific enolase(NSE),cytokeratin 19 fragment(CYFRA21-1),squamous cell carcinoma antigen(SCCAg)in the diagnosis of lung cancer.Methods 20 patients with lung cancer,42 patients with lung benign diseases and 54 healthy people undergoing the physical examination in this hospital from September 2014 to November 2016 were served as the lung cancer group,benign diseases group and healthy control group respectively.The Abbott microparticle chemiluminescence instrument was used to detect CYFRA21-1 and SCCA levels,the Roche electrochemical luminescence instrument was used to detect the NSE level and the TSGF level was de-tected by using the Olympus 5400 biochemical analyzer.Then the detection results were statistically analyzed. Results The levels of serum TSGF and NSE in the lung cancer group were higher than those in the lung be-nign diseases group and healthy control group,and the differences were statistically significant(P< 0.05). The serum CYFRA21-1 level of the lung benign disease group was higher than that in the healthy control group(P<0.05).The sensitivity and specificity of TSGF,NSE,CYFRA21-1 and SCCAg combined detection were 90.00% and 93.00% respectively.The area under the ROC curve was 0.959.Conclusion TSGF posses-ses wide spectrum marker characteristics,has a certain value for screening lung cancer,moreover its combined detection with NSE,CYFRA21-1 and SCCAg can increase the accuracy in diagnosis of lung cancer.
Résumé
Objective To evaluate the diagnostic value of three tumor markers ,including alpha‐fetoprotein(AFP) ,golgi glyco‐protein 73(GP73)and tumor specific growth factor(TSGF) ,and significance of combined detection in diagnosis of primary liver cancer(PHC) .Methods Serum levels of AFP ,GP73 and TSGF were detected in 90 cases of patients with PHC(PHC group) ,52 cases of patients with liver metastasis(liver metastasis group) ,41 cases of patients with benign liver disease(benign liver disease group) ,and 55 cases of healthy individuals(healthy control group) .And clinical value of combined detection of AFP ,GP73 and TS‐GF for diagnosing PHC was analysed .Results The serum levels of AFP ,GP73 and TSGF were significantly higher than those in benign liver disease group and healthy control group ,the differences were statistically significant(P< 0 .05) .The specificity of AFP ,GP73 and TSGF in diagnosis of PHC was 79 .7% ,71 .6% and 83 .1% ,respectively .The sensitivity of AFP ,GP73 and TSGF in the diagnosis of PHC was 57 .8% ,74 .4% and 65 .6% ,respectively .The combined detection of AFP ,GP73 and TSGF improved the sensitivity for diagnosing PHC(96 .6% ) ,while the specificity of combined detection was decreased(68 .9% ) .And the diagnosis rates of PHC patients with negative AFP or low levels of AFP were increased when combined the three tumor markers . Conclusion Combined detection of AFP ,GP73 and TSGF as a significant indicator for diagnosing PHC could improve the diagnosis rate of PHC .
Résumé
Objective To investigate the diagnostic significance of lysophosphatidic acid (LPA) ,tumor specific growth factor (TSGF) and carbohydrate antigen 153 (CA153) in breast cancer .Methods Serum levels of LPA ,TSGF and CA153 were detected in 97 cases of breast cancer (cancer group) ,43 cases of benign breast disease (benign group) and 50 healthy females (control group) .Diagnostic significances of these parameters were analyzed .Results Serum levels of LPA ,TSGF and CA153 in cancer group were significantly higher than benign group and control group (P<0 .05) .Diagnostic sensitivity and specificity of combined detection of LPA ,TSGF and CA153 was higher than individual testing (P<0 .05) .Conclusion Combined detection of tumor mark‐ers could improve the diagnostic specificity and sensitivity of breast cancer ,and provide reliable experimental basis for diagnosis .