Clinical analysis of bilateral native pelvic and ureteral transitional cell carcinoma following renal transplantation / 中华器官移植杂志

Objective To investigate the clinical features of bilateral native pelvic and ureteral transitional cell carcinoma (TCC) in renal transplant patients. Methods A retrospective analysis was carried out on 16 patients with bilateral native pelvic and ureteral TCC after kidney transplantation.The mean time between transplantation and diagnosis of upper urinary TCC was 56. 2 ± 33. 0 months.Two patients were suffered from bilateral upper urinary TCC at the same time. The mean interval between 2 upper urinary tract operations of the remaining 14 cases was 8. 6 ± 6. 7 months. Hematuria and hydronephrosis of native kidneys were the main symptoms and targets in checkup. Intravesical chemotherapy was postoperatively given. Results All operations were performed successfully. All specimens obtained from the operations were pathologically diagnosed as TCC. The TCC location involved pure native pelvis (n = 4), pure native ureter (n = 9), and pelvis combined with ureter (n = 19). Pelvic TCC pathological grades included grade 1 in 8 cases, grade 2 in 11 cases, and grade 3 in 4 cases; Ureteral TCC grades included grade 1 in 6 cases, grade 2 in 10 cases, and grade 3 in 12 cases.Patients were followed up for 26. 8 ± 25. 1 months. One patient died of lung metastasis. (One case of lumbar soft tissue transfer was given local excision. The remaining patients had no recurrence and metastasis. Conclusion Renal transplant patients with hematuria and native renal hydronephrosis should be highly vigilant of the occurrence of upper urinary tract TCC. TCC after renal transplantation is invasive. Prophylactic contralateral nephroureterectomy should be performed on the recipients having TCC at the bladder and one side of native upper urinary tract.

A Clinical Observation on Malignant Tumors of Renal Pelvis and Ureter / 대한비뇨기과학회지

A clinical observation was performed on 15 cases of the primary renal pelvic and the ureteral tumors, observed in our clinic during the period from Jan. 1962 to Dec. 198O. The results were as follows; The incidence of the renal pelvic and the ureteral tumors among the 335 genitourinary tumors during the period was 4.5% (15 cases). Male to female ratio was 2.8:1 and right to left ratio was 2:1 in the renal pelvic and the ureteral tumors. The seventy five percent of the ureteral tumor occurred in the lower ureter. 2. The most common symptom was hematuria in the renal pelvic and the ureteral tumors. 3. Urographic findings in the renal pelvic tumor were filling defect in 5 cases (71.4%) and non functioning kidney in 2 cases (28.6%). In the ureteral tumor, hydronephrosis was 5 cases (62.5%), non functioning kidney in 3 cases (37.5%) and filling defect in 2 cases (25.0%). 4. Treatment of the renal pelvic and the ureteral tumors was performed surgery in all cases. In the renal pelvic tumor, 5 nephroureterectomies, 1 nephrectomy and 1 nephroureterctomy with excision of the bladder cuff were performed. In the ureteral tumor, 5 nephroureterectomies with excision of bladder cuff and 3 nephroureterectomies were done. 5. Histologic analysis showed transitional cell carcinoma in all cases. Histologic grade and stage showed a close correlation with prognosis.

A Case of Primary Ureteral Tumor / 대한비뇨기과학회지

Recently, primary ureteral tumors are more frequently reported in urological field even though considered as rare. We have observed a case of primary ureteral tumor confirmed with the cystoscopy and retrograde pyeloureterogram. Choice of operation is nephro-ureterectomy with removal of a cuff of bladder wall around the ureteral orifice. It is necessary for a physician to make the early diagnosis and removal of the tumor as soon as possible.