Síndrome de Good y aplasia pura de la serie roja, reporte de un caso y revisión de la literatura: Report of one case / Association of Good syndrome with pure red cell aplasia

Background: The association between Good's syndrome (hypogammaglobulinemia and thymoma) with pure red aplasia is very uncommon. We report a 70-year-old male, who had a thymoma excised nine years before. Afterwards, he suffered frequent respiratory infections, which were attributed to a humoral immunodeficiency. Nine years later, he developed a pure red cell aplasia. He received prednisone and cyclosporine, resulting in a progressive rise of hemoglobin level, after one month of treatment. The patient died shortly thereafter due to infection, complicating a domestic accident.

Anemia grave en un paciente con infección por el virus de inmunodeficiencia humana / Severe anemia in a patient with human immunodeficiency virus infection

La anemia es relativamente frecuente en pacientes con infección avanzada por VIH. La aplasia pura de la serie roja (APSR) asociada a la infección por Parvovirus B19 (PVB19) se caracteriza por la ausencia de precursores eritroides en la médula ósea que produce anemia grave normocítica, normocrómica, con un bajo recuento de reticulocitos. Este artículo describe un paciente con infección por VIH con inmunosupresión grave y en fracaso virológico que desarrolló APSR asociada a PV B19.

Severe anemia is quite frequently seen in HIV infected patient with advanced disease. Pure red cell aplasia associated to Parvovirus B19 (PVB 19) infection is characterized by the absence of erythroid precursors in the bone marrow resulting in severe normocytic-normochromic anemia with a low reticulocyte count. This article reports a patient with advanced HIV and virological failure, who developed pure red cell aplasia associated to PVB19.