Sujets)
Anticorps/analyse , Anticoagulants/effets indésirables , Antithrombiniques/usage thérapeutique , Benzimidazoles/usage thérapeutique , Chondroïtines sulfate/usage thérapeutique , Chondroïtine sulfate B/usage thérapeutique , Fibrinolytiques/usage thérapeutique , Héparine/effets indésirables , Héparine/immunologie , Héparitine sulfate/usage thérapeutique , Hirudines , Fragments peptidiques/usage thérapeutique , Acides pipécoliques/usage thérapeutique , Antiagrégants plaquettaires/usage thérapeutique , Polyosides/usage thérapeutique , Pyridines/usage thérapeutique , Protéines recombinantes/usage thérapeutique , Thrombine/antagonistes et inhibiteurs , Thrombopénie/induit chimiquement , Thrombopénie/thérapieSujets)
Anticoagulants/usage thérapeutique , Antithrombiniques/usage thérapeutique , Benzimidazoles/usage thérapeutique , Humains , Morpholines/usage thérapeutique , Acides pipécoliques/usage thérapeutique , Pyrazoles/usage thérapeutique , Pyridones/usage thérapeutique , Thiophènes/usage thérapeutique , Thromboembolisme veineux/prévention et contrôle , bêta-Alanine/analogues et dérivés , bêta-Alanine/usage thérapeutiqueRésumé
The concept of neuroprotection relies on the principle that delayed neuronal injury occurs after ischemia. The phenomenon of the "ischemic cascade" has been described, and each step along this cascade provides a target for therapeutic intervention. A wide variety of drugs have been studied in humans. Ten classes of neuroprotective agents have reached phase III efficacy trials but have shown mixed results. They included calcium channel antagonists, NMDA receptor antagonists, lubeluzole, CDP-choline, the free radical scavenger tirilazad and ebselen, enlimomab, GABA agonist clomethiazole, the sodium channel antagonist fosphenytoin, magnesium, glycine site antagonist GV150526 and piracetam. Furthermore, the mechanisms that underlie the development of focal ischemic injury continue to be discovered, opening new therapeutic perspective for neuroprotection that might clinically be applicable in the future.