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1.
São Paulo med. j ; 133(1): 67-67, Jan-Fev/2015.
Article Dans Anglais | LILACS | ID: lil-733005

Résumé

BACKGROUND: Shift work results in sleep-wake disturbances, which cause sleepiness during night shifts and reduce sleep length and quality in daytime sleep after the night shift. In its serious form it is also called shift work sleep disorder. Various pharmacological products are used to ameliorate symptoms of sleepiness or poor sleep length and quality. OBJECTIVES: To evaluate the effects of pharmacological interventions to reduce sleepiness or to improve alertness at work and decrease sleep disturbances whilst of work, or both, in workers undertaking shift work. METHODS: Search methods: We searched CENTRAL, MEDLINE, EMBASE, PubMed and PsycINFO up to 20 September 2013 and ClinicalTrials.gov up to July 2013. We also screened reference lists of included trials and relevant reviews. Selection criteria: We included all eligible randomised controlled trials (RCTs), including cross-over RCTs, of pharmacological products among workers who were engaged in shift work (including night shifts) in their present jobs and who may or may not have had sleep problems. Primary outcomes were sleep length and sleep quality while of work, alertness and sleepiness, or fatigue at work. Data collection and analysis: Two authors independently selected studies, extracted data and assessed risk of bias in included trials. We performed meta-analyses where appropriate. ...


Sujets)
Humains , Hypnotiques et sédatifs/usage thérapeutique , Mélatonine/usage thérapeutique , Troubles du rythme circadien du sommeil/traitement médicamenteux , Sommeil/effets des médicaments et des substances chimiques , Agents promoteurs de l'éveil/usage thérapeutique
2.
Acta Pharmaceutica Sinica ; (12): 372-376, 2013.
Article Dans Chinois | WPRIM | ID: wpr-235657

Résumé

According to the structure-activity relationships (SARs) of modafinil, a therapeutic drug of hypnolepsy, we designed and synthesized two series of compounds 2-[(diphenylmethane)sulfinyl] acetamides and 2-[(diphenylmethyl)thio] acetamides, and measured their biological activities. The target compounds (6a-6o) were synthesized beginning with diphenyl carbinol by substitution, oxidation, acylation and so on. Their structures were confirmed by ESI-MS, 1H NMR and elemental analysis. The central stimulatory effects of the target compounds were determined by the independent activity assay on mice. Compounds 6c, 6f and 6n have considerable activities, while the central stimulative effect of 6h is slightly better than the positive control modafinil.


Sujets)
Animaux , Souris , Acétamides , Chimie , Pharmacologie , Comportement animal , Composés benzhydryliques , Chimie , Pharmacologie , Dérivés du biphényle , Chimie , Pharmacologie , Méthane , Chimie , Pharmacologie , Souris de lignée ICR , Répartition aléatoire , Relation structure-activité , Agents promoteurs de l'éveil , Chimie , Pharmacologie
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