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1.
Journal of Zhejiang University. Science. B ; (12): 603-610, 2020.
Article Dans Anglais | WPRIM | ID: wpr-1010540

Résumé

Thoracic aortic dissection (TAD) is one of the most lethal aortic diseases due to its acute onset, rapid progress, and high rate of aortic rupture. The pathogenesis of TAD is not completely understood. In this mini-review, we introduce three emerging experimental mouse TAD models using β-aminopropionitrile (BAPN) alone, BAPN for a prolonged duration (four weeks) and then with added infusion of angiotensin II (AngII), or co-administration of BAPN and AngII chronically. We aim to provide insights into appropriate application of these three mouse models, thereby enhancing the understanding of the molecular mechanisms of TAD.


Sujets)
Animaux , Mâle , Souris , Amino-propionitrile/toxicité , /anatomopathologie , Angiotensine-II/toxicité , Anévrysme de l'aorte thoracique/anatomopathologie , Modèles animaux de maladie humaine , Souris de lignée C57BL
2.
Article Dans Anglais | IMSEAR | ID: sea-24707

Résumé

BACKGROUND & OBJECTIVE: It is not clear how lathyrism affects the systemic bone metabolism. We therefore undertook a study to observe periodontal and systemic bone changes by performing radiological, metabolic, and bone densitometric evaluations in rats with experimental lathyrism. METHODS: A total of 30 rats were used. Experimental lathyrism was induced by once daily subcutaneous administration of beta-aminopropionitrile (beta-APN), at a dose of 5 mg beta-APN/0.4 ml per 100 g of body weight for 40 days. After 40 days, vertebral bone mineral density was analyzed by means of dual energy X-ray absorbtiometry in both groups. Blood was drawn by cardiac puncture and the animals were decapitated. Serum calcium levels were measured. Right mandibles were removed and radiographs were obtained. Alveolar bone level was determined in the radiographs. RESULTS: In all lathyritic rats, alveolar bone level was pathologically decreased with visible resorption. Vertebral bone mineral density values of lathyritic rats did not differ significantly from those of the control group. Compared to controls, there was a statistically significant decrease in serum calcium levels in the lathyritic group (P<0.001). INTERPRETATION & CONCLUSION: Significant alveolar bone resorption without alterations in vertebral bone mineral density indicated that lathyrogen administration for 40 days presumably has not caused systemic demineralization. This model could be used for studying the role of local and systemic agents on periodontal alveolar bone resorption.


Sujets)
Processus alvéolaire/effets des médicaments et des substances chimiques , Amino-propionitrile/toxicité , Animaux , Densité osseuse/effets des médicaments et des substances chimiques , Résorption osseuse/induit chimiquement , Os et tissu osseux/effets des médicaments et des substances chimiques , Lathyrisme/induit chimiquement , Mâle , Parodonte , Rats , Rat Wistar
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