Death following intentional overdose of psychotropic drugs.

A case of successful suicide from overdose of amitriptyline, perphenazine, and midazolam is described. Postmortem findings were inadequate to explain the death. Sudden cardiac arrest suggested that the death from overdose probably resulted from drug cardiotoxicity. The physicians should be aware of this serious complication when prescribing a combination of these potential lethal drugs. A limited supply should be given to depressed patients.

Cardiotoxicidade na intoxicaçäo aguda por antidepressivo tricíclico: relato de caso / Cardiotocicity in acute poisoning by tricyclic antidepressives: a case report

As intoxicaçöes agudas por antidepressivos tricíclicos estäo entre as primeiras causas de morte por ingestäo de drogas. As manifestaçöes neurológicas e cardiológicas responsáveis pela gravidade de tais intoxicaçöes säo extremamente importantes. É apresentado o caso de uma paciente, de 26 anos que ingeriu 1500 mg de amitriptilina sendo observada taquicardia sinusal com BAV de 1§ grau revertido com salicilato de fisostigmine