Screening of benzodizepines and their metabolites in urine / 法医学杂志

OBJECTIVE@#Screen seventeen benzodizepines and their metabolitesin urine by GC/ECD and GC/MS.@*METHODS@#They were GC (GC/ECD, GC/MS) assay of benzodizepines and GC (GC/ECD, GC/MS) assay of benzophenones of acid-hydrolytic products of 1,4-benzodizepines.@*RESULTS@#The methods were simple and sensitive. The recoverys were 60% to 90% of most benzodizepines, linear calibration curves were 20 ng/ml-200 ng/ml (r > 0.99), and detection limits were 0.5 ng/ml-10 ng/ml.@*CONCLUSION@#They methods were evaluated with human urine samples.