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Article de Anglais | IMSEAR | ID: sea-18360

RÉSUMÉ

Experiments were conducted to study the effects of high density lipoprotein (HDL) and apolipoproteins C, E, and A on lipoprotein lipase activity in rhesus monkeys. The lipoprotein lipase activity was inhibited up to 32 +/- 6 per cent by monkey HDL. This inhibition was considerably decreased (2 +/- 0.02%) by using apolipoprotein-poor HDL. Apolipoproteins C and E inhibited the hydrolysis of activated intralipid by monkey lipoprotein lipase to a maximum of 83 +/- 7 and 57 +/- 5 per cent respectively. Apolipoprotein A produced little inhibition of lipoprotein lipase activity. The results of these studies demonstrate that HDL and apolipoproteins compete with the substrate for the binding to lipoprotein lipase in rhesus monkeys.


Sujet(s)
Animaux , Apolipoprotéines A/pharmacologie , Apolipoprotéines C/pharmacologie , Apolipoprotéines E/pharmacologie , Lipoprotein lipase/antagonistes et inhibiteurs , Lipoprotéines HDL/pharmacologie , Macaca mulatta , Mâle
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