Maternal metal concentration during gestation and pediatric morbidity in children: an exploratory analysis

BACKGROUND@#The majority of studies linking exposure to metals with certain health outcomes focus on known toxic metals. Alternatively, this study assesses the extent to which exposure to a wider range of metals during gestation is associated with childhood morbidity.@*METHODS@#We analyzed the concentrations of 25 metals found in urine samples of 111 pregnant women of Arab-Bedouin origin collected prior to birth. In addition, we collected medical records on their offspring for six years following birth, including every interaction with HMOs, local hospitals, and pharmacies.@*RESULTS@#The main types of morbidities diagnosed and treated during this period were preterm births, malformations, asthma-like morbidity, cardiovascular and behavioral problems, and obesity. Multivariable analysis showed that offspring born before term were more likely to have been exposed to elevated maternal concentrations of zinc, thallium, aluminum, manganese, and uranium, all with adjusted relative risk above 1.40 for an increase by each quintile. Likewise, children with asthma had been exposed to higher levels of magnesium, strontium, and barium at gestation, while behavioral outcomes were associated with elevated biometals, i.e., sodium, magnesium, calcium, selenium, and zinc, as well as higher levels of lithium, cobalt, nickel, strontium, cadmium, vanadium, arsenic, and molybdenum. A heatmap of adjusted relative risk estimates indicates the considerable implications that exposure to metals may have for preterm birth and developmental outcomes.@*CONCLUSIONS@#The current study shows that perinatal exposure to metals is adversely associated with pediatric morbidity. Further such analyses on additional samples are warranted.

Nutritional status of Palestinian children attending primary health care centers in Gaza.

OBJECTIVE: To assess the nutritional status of Palestinian children less than two years old and the associated risk factors. METHODS: The study was descriptive cross-sectional of 102 children attending the main four primary health care centers in the Gaza Strip during summer 2003. Data were collected through medical records and meeting interviews with children's mothers by face to face. Questionnaire was subjected to validity and reliability procedures before being used. Descriptive analyses and cross tabulation were used. RESULTS: The study showed that the prevalence of anemia was 72.8% among children. Anthropometrical indices showed that the prevalence of wasting, stunting, underweight were 34.3%, 31.4%, 31.45% respectively. CONCLUSION: Palestinian children are at high risk of health problems related to malnutrition. Informing Gazean families about the importance of following healthy dietary habits especially breastfeeding could improve child's nutritional status in parallel with overcoming the devastating economic condition.

Cancer incidence in the Middle Eastern population of California, 1988-2004.

International statistics suggest lower cancer incidence in the Middle East and Middle Eastern (ME) immigrants in Europe, Australia, and Canada, but little is known from the United States. This study compares cancer rates in ME population with other race/ethnic groups in California from 1988 through 2004. ME cases in California cancer registry were identified by surname and ME population was estimated from U.S. Census data. Cancer rates for ME countries was obtained from Globocan. The ME incidence rate ratios for all sites combined in male and female were 0.77 and 0.82, respectively and were statistically significant. ME rates were significantly lower for cancers of the colon, lung, skin melanoma, female breast and prostate, and were significantly higher for cancers of the stomach, liver, thyroid, leukemia, and male breast. Cancer incidence in ME population in California was 2.4 times higher than rates in home countries. Incidence trends in ME males remained fairly stable but in females shows a slight decline in recent years. Cancer incidence in ME population is lower than non-Hispanic white and non-Hispanic Black, but is higher than rates for Hispanics and Asians, and ME countries. Improved data quality, chronic infections, acculturation, and access to screening services are some of the factors responsible for the observed pattern.

Factors associated with iron depletion and iron deficiency anemia among Arabic preschool children of the United Arab Emirates

The purpose of this study was: 1. To estimate the prevalence of iron depletion and iron deficiency anemia in preschool Arabic children of the United Arab Emirates [UAE], and 2. To determine the risk factors associated with these conditions in this population of children. From April through to October 2000 a questionnaire and capillary blood survey was carried out in one primary health care [PHC] centre of Al Ain, UAE. Children whose capillary hemoglobin [Hb] or mean cell volume [MCV] results fell below predetermined cutoffs were offered venous blood workup. An additional sample of children with capillary blood results above those cutoffs were offered the same workup. All blood sampling was completed by May 2001. Five hundred and eight parents were questionnaired and 496 children capillary blood tested. Of the 320 venous blood tested, 315 were analyzed, in relation to questionnaire responses, using univariate analysis and logistic regression. Anemia, iron depletion and iron deficiency anemia were found in an estimated 36.1%, 26%, and 9.9% of this population of children. Age was a significant independent predictor of both iron depletion and iron deficiency anemia. Mother's current pregnancy was an additional predictor of iron deficiency anemia. The prevalences of iron depletion and iron deficiency anemia in this population of children were consistent with other reports from the region. Child's age and mother's current pregnancy were predictors of iron deficiency anemia. These findings have important implications for antenatal and childcare both in hospital and primary health care clinics

Cardiovascular risk factors in Saudi Arabian and non-Saudi Arabian diabetic patients in Saudi Arabia

To determine frequency of cardiovascular risk factors in Saudi and non-Saudi diabetics, we studied patients attending King Abdulaziz University Hospital for follow-up in the period January 1997 to December 2001. Cardiovascular risk factors, including hypertension, hyperlipidaemia, obesity and smoking, were studied as well as degree of blood glucose control. Of 1122 patients in the study, 48% were Saudis and 52% non-Saudis. No statistically significant difference was found for prevalence of cardiovascular risk factors between the two groups. Correlation of each of the risk factors to patient's age showed significant correlation to hypertension and smoking

Racial variation in risk factors and occurrence of acute myocardial infarction: comparison between Arab and South Asian men in Kuwait.

BACKGROUND: There are little data available on the rates of occurrence, risk factors and mortality due to acute myocardial infarction among the various ethnic groups living in Middle-East countries. Therefore, we did a study to compare Arabs and South Asians living in Kuwait. METHODS AND RESULTS: The data for this retrospective study were collected from the computerized database of the Coronary Care Unit at the Mubarak Al-Kabeer Hospital (a 476-bed teaching hospital) and the 1997-2000 Census data for the State of Kuwait. Arab and South Asian men above 25 years admitted between September 1997 and August 2000 with a diagnosis of acute myocardial infarction were included in the study A total of 866 Arabs and 277 South Asian men were admitted. The rate of admission for the entire patient population was two-fold higher among Arabs as compared with South Asians (6.7/1000 population and 3.3/1,000, respectively). Diabetes mellitus was present in 453 Arabs (52.3%) and 109 South Asians (39.4%) (p< or = 0.001) of those >25 years of age. Hypertension was recorded in 247 Arabs (28.5%) and 57 South Asians (20.6%) (p < or = 0.01). Among patients <55 years of age (454 Arabs and 226 South Asians); the rate of admission was 4.0/1,000 in Arabs and 3.5/1,000 in South Asians (not significant). Hypertension was present in 97 Arabs (21.3%) and 43 South Asians (19%) (not significant). Diabetes mellitus was present in 202 Arabs (44.5%) and 80 South Asians (35.4%) (p < or = 0.05). Smoking was recorded in 353 Arabs (77.8%) and 160 South Asians (70.8%) (notsignificant). Hypercholesterolemia was presentin 182 (40.1%) and 88 (39%), respectively (not significant). While in hospital, 11 Arabs and 9 South Asians died (not significant). CONCLUSIONS: Among men >55 and <75 years of age, Arabs had a higher rate of admission with acute myocardial infarction compared with men of South Asian origin. The incidence of diabetes and hypertension was significantly higher among Arabs in this age group. In younger patients (<55 years), the rate of acute myocardial infarction was not different between the two groups; however, diabetes was present more often among Arabs. The smoking rate is very high in both groups and is an important risk factor for both Arab and South Asian men living in the Middle East.

Caries prevalence, oral hygiene and orthodontic status of Saudi Bedouin children.

The objectives of the study were to determine caries prevalence, oral hygiene and orthodontic status of Bedouin children in a desert around Al-Qasseem Region of Saudi Arabia. One hundred and fifty three children were examined for caries, oral hygiene and orthodontic status with mirror and explorer utilizing natural light. These children were divided into two groups for analyses. The primary dentition group consisted of 77 children, 39 (50.6%) male and 38 (49.4%) female with a mean age of 4.0 (+/- 1.4) years. The mixed dentition group consisted of 76 children, 67 (88.2%) male and 9 (11.8%) female with a mean age of 9.7 (+/- 2.9) years. In Primary dentition group, 16 (20.8%) children were caries positive and mean DMFT was 0.91 (+/- 2.42). There was a highly significant relation (p < .001) between oral hygiene and caries. In the mixed dentition group, 15 (19.7%) children were caries positive. The mean DMFT and DMFT scores for these children were 0.72 (+/- 1.96) and 0.74 (+/- 1.48) respectively. There was a significant relation (P > .01) between oral hygiene and caries. One hundred and fifty one (98.6%) children had class I molar relation and 2 (1.4%) children had class II molar relation. Anterior open bite, anterior crossbite and posterior crossbite were found in one case (0.7%) each. The caries experience of these Bedouin children was low both in terms of prevalence and severity. There was a significant relation between oral hygiene and caries. The orthodontic problems were almost nonexistent in the study population.

Epidemiological and clinical patterns of diabetes mellitus in Benghazi, Libyan Arab Jamahiriya

The clinical characteristics and prevalence of non-insulin-dependent diabetes mellitus [NIDDM] diagnosed in Benghazi are reported. Data were based on the analysis of records for the period 1981 to 1990. A total of 8922 NIDDM cases [4081 males, 4841 females] were registered during the study period. The overall prevalence rate of NIDDM was 0.19%; it was significantly higher in females [0.21%] than males [0.17%] [P < 0.01]. The prevalence rate in patients aged > or = 20 years was 3.8% and was significantly higher in females [4.7%] than in males [2.9%] [P < 0.01]. Prevalence rates increased with each higher age group and peaked in the 50-54 years age group. Prevalence of hypertension was 22.5% and prevalence of overweight was 59.4%. The most common complications of diabetes were neuropathy [45.7%], retinopathy [30.5%] and nephropathy [25.2%]