Résumé
This study was carried out on 445 pregnant patients in the first trimester and had one or more risk factors for abortion. After taking history and clinical examination, estimation of serum progesterone, hCG and APA [ACA and APTT] were done on day 43 to 56 of the estimated gestational age. At the end of the first trimester, the results showed that total incidence of abortion was 17.5%. The following risk factors were associated with a high incidence of abortion: Elderly patients, abnormal weight, primigravidae, para, previous abortions, hypertension, autoimmune disorders and endocrine abnormalities. Patients with abnormally low serum progesterone or hCG levels had significantly a higher incidence of abortion than patients with normal levels. Antiphospholipid antibodies were positive in 12.4% of all patients, 25.5% of them had first trimester abortion. Aborted patients with positive APA had significantly a higher incidence of abortion and higher levels of IgG and IgM of ACA and prolonged APTT than aborted patients with negative APA, there was no significant difference between them regarding age, weight, MAP, progesterone and hCG level. Measurement of ACA was more accurate in the prediction of the first trimester abortion than APTT