Résumé
Oxydemeton-methyl, an organophosphate insecticide and acaricide produced decrease in the exploratory behaviour and prolongation of barbitone sodium induced hypnosis in rats after intermittent aerosol spray inhalational exposure, for 1/2 hour daily for 7 consecutive days, compared to the saline control group. Further, ED50 +/- SEM value for haloperidol induced catalepsy, CD50 +/- SEM value for pentylenetetrazole induced seizure and CI50 +/- SEM value for electroshock (i.e. the dose of haloperidol, PTZ and intensity of electroshock producing catalepsy or positive seizure response in 50% of rats) were significantly decreased after 7 days exposure to oxydemeton-methyl compared to that of saline control group. The study has established the central nervous system depressant effect, extrapyramidal effect and proconvulsant potential of oxydemeton-methyl which is widely used by the agricultural workers in the form of field spray.
Sujets)
Animaux , Neuroleptiques/toxicité , Barbital/pharmacologie , Comportement animal/effets des médicaments et des substances chimiques , Catalepsie/induit chimiquement , Convulsivants , Électrochoc , Comportement d'exploration/effets des médicaments et des substances chimiques , Femelle , Halopéridol/toxicité , Hypnotiques et sédatifs/pharmacologie , Insecticides/toxicité , Mâle , Système nerveux/effets des médicaments et des substances chimiques , Composés organothiophosphorés/toxicité , Pentétrazol , Rats , Rat Sprague-Dawley , Crises épileptiques/induit chimiquement , Sommeil/effets des médicaments et des substances chimiques , Facteurs tempsRésumé
Oxydemeton-methyl, an organophosphate insecticide and acaricide produced decrease in the exploratory behaviour and prolongation of barbitone sodium-induced hypnosis after intermittent aerosol spray inhalational exposure for 1 h in rats compared to the saline control group. Further, CD50 +/- S.E.M. value for pentylenetetrazole (PTZ) and CI50 +/- S.E.M. value for electroshock (i.e. the dose of PTZ and intensity of electroshock producing positive seizure response in 50% of rats) were significantly decreased by acute exposure to oxydemeton-methyl compared to that of saline control group. The study has established the central nervous system depressant effect and proconvulsant potential of oxydemeton-methyl which is widely used by the agricultural workers in the form of field spray.
Sujets)
Animaux , Barbital/pharmacologie , Comportement animal/effets des médicaments et des substances chimiques , Convulsivants , Électrochoc , Comportement d'exploration/effets des médicaments et des substances chimiques , Femelle , Hypnotiques et sédatifs/pharmacologie , Insecticides/toxicité , Mâle , Syndromes neurotoxiques/psychologie , Composés organothiophosphorés/toxicité , Pentétrazol , Équilibre postural/effets des médicaments et des substances chimiques , Rats , Rat Sprague-Dawley , Crises épileptiques/induit chimiquementRésumé
In rats, propranolol potentiated alcohol and pentobarbitone hypnosis, but not barbital sleeping time, indicating enzyme inhibition as a possible mechanism of potentiation. Propranolol showed anticonvulsant effect on normal and reserpine treated rats by MES test, but showed dose related lowering of MET. Probable mechanisms are discussed.