Pharmacokinetics of cefazolin and chloramphenicol in nephrotic syndrome among children

The antibacterial levels of Cefazolin and of Chloramphenicol were assayed microbiologically in the serum and urine of children suffering from nephrotic syndrome. Twenty five children suffering from nephrosis with equal number of normals as control of same sex were the subject of this study. The bioavailability of Cefazolin after parenteral route was found to be higher in corticosteroid resistant nephrotic syndrome with parallel lowering of urinary concentrations, while in corticosteroid sensitive nephrotics no variations from normal were noticed. Study of chloramphenicol levels in serum and urine did not show significant change from normal. The possible mechanism of these changes is discussed

Pharmacokinetics of cefazolin and chloramphenicol in protein-energy malnuirition

The antibacterial levels of cefazolin and chloramphenicol-Chloramphenicol were assayed in the serum by a microbiological method using Sarcina lutea as the test organism. Twenty infants and children suffering from protein-energy malutrition [PEM] compared to normal controls of the same age and sex were the subject of this study. All children were studied on two separate occasions with a seven to ten days interval between the two studies. The bioavailabitity of chloramphenicol for parenteral route was found to be significantly higher in malnourishd infants and children compared to normal controls, while with cefazolin no variation from normal was noticed. Concomitant higher levels of chioram were assayed in the serum by a microbiological method using Sarcina lutea as the test organism