Relationship between nutritional status and sleep duration in Chilean school-age children

To establish the relationship between sleep duration, nutritional status and caffeinated beverage consumption patterns in school-age Chilean children. Method: The study was conducted in 805 schoolage children, between 6- and 10-years old from 6 neighborhoods in Santiago, Chile. Parents completed a questionnaire, which assessed sleep duration, physical activity and food intake. Anthropometric measurements were completed for children. Results: 52.6% of school-age children were obese and 46.4% slept the recommended amount (≥10 hours). Normal weight subjects slept significantly more hours than obese participants, 9.8 ± 0.9 vs. 9.6 ± 0.9, respectively. Sleep duration during the week was inversely associated to obesity (OR: 3.5, 95% CI 1.3-9.2). Children drank the following beverages at night: caffeinated soft drinks (52.2 %), coffee and/or tea (32.6%) and 21.2 % both soft drinks and coffee tea caffeine beverages Conclusion: Over half of this sample of school-age Chilean children slept less than the recommended (≥10 hours) amount, with obese participants sleeping less than normal weight subjects. The intake of caffeine products in particular, caffeinated soft drinks,was higher during the night in both groups(AU)

Establecer la relación entre cantidad de sueño, estado nutricional y consumo de cafeína en escolares Métodos: El estudio fue realizado en 805 escolares, entre 6 a 10 años de 6 comunas de Santiago de Chile. Los padres completaron las encuestas de sueño, actividad física y consumo de alimentos. A los escolares se les realizó una evaluación antropométrica. Resultados: El 56,2% de los escolares era obeso, el 46,4% dormía menos de lo recomendado (≥10 horas). La cantidad de sueño fue significativamente mayor en los escolares normopeso que en los obesos 9,8 ± 0,9 vs 9,6 ± 0,9, respectivamente. La cantidad de sueño durante la semana fue inversamente asociada a obesidad (OR: 3,5; 95% CI 1,3-9,2). Los escolares bebían en la noche antes de dormir: bebidas carbonadatas con cafeína (52,2%), café y/o té (32,6%) y un 21,2% ambos tipos de bebidas. Conclusión: Más de la mitad de esta muestra de niños en edad escolar, dormia menos de la cantidad recomendada (≥ 10 horas), los escolares obesos dormían menos de sujetos de peso normal. Además se observa una ingesta en la noche de bebidas carbonatadas con cafeína elevada en ambos grupos(AU)

Effects of caffeine, tea polyphenol and daidzein on the pharmacokinetics of lansoprazole and its metabolites in rats

abstract The aim of this study was to evaluate the effects of caffeine, tea polyphenol and daidzein on the pharmacokinetics of lansoprazole and its metabolites. Rats were intragastrically administered caffeine (30 mg·kg-1, once per day), tea polyphenol (400 mg·kg-1, once per day) or daidzein (13.5 mg·kg-1, once per day) for 14 days, followed by an intragastric administration of lansoprazole (8 mg·kg-1) on the 15th day. The plasma concentrations of lansoprazole and its two primary metabolites, 5-hydroxylansoprazole and lansoprazole sulfone, were determined by high-performance liquid chromatography coupled with tandem mass spectrometry (HPLC-MS/MS). Tea polyphenol significantly elevated the Area Under the Curve (AUC) of lansoprazole from 680.29 ± 285.99 to 949.76 ± 155.18 μg/L.h and reduced that of lansoprazole sulfone from 268.82 ± 82.37 to 177.72 ± 29.73 μg/L.h. Daidzein increased the AUC of lansoprazole from 680.29 ± 285.99 to 1130.44 ± 97.6 μg/L.h and decreased that of lansoprazole sulfone from 268.82 ± 82.37 to 116.23 ± 40.14 μg/L.h. The pharmacokinetics of 5-hydroxylansoprazole remained intact in the presence of tea polyphenol or daidzein. Caffeine did not affect the pharmacokinetics of lansoprazole and its metabolites. The results imply that tea polyphenol and daidzein may inhibit the in vivo metabolism of lansoprazole by suppressing CYP3A.

resumo O objetivo deste estudo foi avaliar os efeitos da cafeína, do polifenol do chá e da daidzeína na farmacocinética do lansoprazol e de seus metabólitos. Administraram-se, intragastricamente, aos ratos cafeína (30 mg·kg-1, uma vez ao dia), polifenol do chá(400 mg·kg-1, uma vez ao dia) ou daidzeína (13,5 mg·kg-1, uma vez ao dia), por 14 dias, seguindo-se a administração de lansoprazol (8 mg·kg-1) no 15º. dia. As concentrações plasmáticas do lansoprazol e de seus dois metabólitos primários, 5-hidroxilansoprazol e sulfona de lansoprazol, foram determinadas por cromatografia líquida de alta eficiência acoplada com espectrometria de massas (CLAE-EM/EM). O polifenol do chá elevou, significativamente, a Área Sob a Curva (ASC) do lansoprazol de 680,29 ± 285,99 para 949,76 ± 155,18 μg/L.h e reduziu a da sulfona de lansoprazol de 268,82 ± 82,37 para 177,72 ± 29,73 μg/L.h. A daidzeína aumentou a ASC do lansoprazol de 680,29 ± 285,99 para 1130,44 ± 97,6 μg/L.h e reduziu a da sulfona de lansoprazol de 268,82 ± 82,37 para 177,72 ± 29,73 μg/L.h. A farmacocinética do 5-hidroxilansoprazol permaneceu intacta na presença de polifenol do chá ou daidzeína. A cafeína não afetou a farmacocinética do lansoprazol e de seus metabólitos. Os resultados sugerem que o polifenol do chá e a daidzeína podem inibir o metabolismo in vivo do lansoprazol por supressão da CYP3A.

Thermodynamic dissociation constant studies of caffeine at different temperatures and in organic water solvent mixture

Thermodynamic dissociation studies have been carried out potentiometrically at various temperatures from 25 to 50oC and in 10, 20, 30 and 40% v/v dioxane-water solvent mixture at 25oC. The influence of temperature and nature of solvent on dissociation equilibria of caffeine is being investigated A computer program in GW-BASIC has been used to calculate the pK values

Effect of black tea on teeth.

Dental caries is the prime cause of premature loss of teeth in children. Tea contains high percentage of fluoride along with polyphenolic constituents which act on GTF of S. mutans in plaque synthesis. Combination of fluoride and polyphenolic constituents inhibit caries activity.

Dependência de cafeína / Caffeine's dependence

Os autores revisaram as drogas, o mecanismo que desencadeia a dependência ao café; estudaram suas complicações e explanaram sobre o tratamento

Efecto del café sobre la velocidad de conducción del nervio cubital / Effects of the coffee on the conduction velocity of the cubital nerve

La medición de la velocidad de conducción es una técnica electrofisiológica para valorar la integridad funcional de los nervios. Multiples factores pueden variarla como ser drogas, el diámetro, mielinización, temperatura, y daño a los axones. Unos de los componentes del café es la cafeína; ésta es estimulante del Sistema Nervioso Periférico. Registramos la velocidad del nervio cubital de 61 sujetos. En cada uno medimos la velocidad de conducción antes y una hora después de la ingesta de 125 mililitros de café. Encontramos una velocidad promedio de 59.29 + 2.73 m/s antes de la ingesta y de 59.14 + 2.85 m/s posterior. No encontramos siginificancia estadística (p<0.785). Concluimos que con el café no encontramos cambios en la velocidad de conducción del nervio cubital

Efecto de la aspirina, cafeina y diazepam sobre la actividad de la glucosa 6 fosfatasa, succinico deshidrogenasa y beta galactosidasa acida en la placenta humana / Effect os aspirin, caffeine and diazepam on glucose 6-phosphatase, succinic dehydrogenase, and acid-galactosidase in human placenta

Se estudio "in vitro" la actividad enzimatica de la beta galactosidasa acida, glucosa 6 fosfatasa y succinico deshidrogenasa para determinar si se afectaban en presencia de aspirina, cafeina y diazepam en homogeneizado total de placenta humana. Se utilizaron dosis de 10, 50 y 100 /ml de cada farmaco, y se determino si existia diferencia significativa en ausencia de los farmacos y en presencia de los mismos mediante la prueba t de Student para series apareadas. En todas las concentraciones de los tres farmacos la beta galactosidasa acida presento un aumento altamente significativo. La glucosa 6 fosfatasa y la succinico deshidrogenasa tuvieron una disminucion altamente significativa, aunque en esta ultima la disminucion fue solosignificativa con la dosis mas pequena. Se concluye que la presencia de aspirina, cafeina y diazepam produce alteraciones en la actividad de las enzimas estudiadas que pueden provocar trastornos del metabolismo placentario