Study of Salivary Gland Neoplasms.

Tumors of the salivary glands are uncommon and they present a great variety of histological types with many structural variation. They have a low incidence and their anatomical relationship especially that of the parotid gland to the facial nerve make their management challenging. The present study was carried out to find out the prevalence of salivary gland neoplasms, to see associated conditions like sialadenitis, sialolithiasis coexisting with salivary gland neoplasms and to do cytohistopathological correlation. Total 96 cases were collected of which 66.7% were benign and 33.3% were malignant. In 81 (84.3%) cases tumors occurred in major salivary gland while 15 (15.6%) cases in minor salivary gland. Among major salivary gland, parotid was the commonest site and in minor salivary glands, palate was the commonest site followed by lips. Pleomorphic adenoma was the commonest benign tumor and adenoid cystic carcinoma was the commonest malignant tumor followed by mucoepidermoid tumor. There was one case of synovial sarcoma. Associated pathology like sialadenitis and sialolithiasis were present in 16 benign and 5 malignant tumors. Cytohistocorrelation was seen in 63 out of 64 (98.4%) benign and 16 out of 18 (88.8%) malignant tumors.

Estudo imunoistoquímico de componentes da Via Sonic Hedgehog, Stat3 e Mcm3 em tumores de glândula salivar / Immunohistochemical study components of Via Sonic Hedgehog, Stat3 and MCM3 in salivary gland tumors

O adenoma pleomórfico (AP), o carcinoma mucoepidermóide (CME) e o carcinoma adenóide cístico (CAC) representam tumores frequentes em glândula salivar. A via de sinalização Sonic Hedgehog (Hh) e o Transdutor de sinal e ativador da transcrição 3 (STAT3) desempenham funções importantes na proliferação celular, favorecendo o desenvolvimento tumoral e a proteína MCM3 tem sido considerada uma nova classe de marcadores de proliferação celular. Portanto, o presente trabalho propõe-se a estudar componentes da via Hh, bem como o STAT3 e o MCM3 em neoplasias de glândula salivar, na tentativa de adicionar informações sobre as características biológicas dessas neoplasias. Foram utilizados 9 casos de AP, 17 casos de CAC e 20 casos de CME e, por meio da técnica imunoistoquímica, realizou-se a detecção das seguintes proteínas: SHH, GLI1, SUFU, HHIP, STAT3 e MCM3. No AP, observou-se alta expressão citoplasmática de SHH e SUFU, e baixa expressão de STAT3 e MCM3. No CAC, observou-se alta expressão de GLI1, HHIP e STAT3 e baixa expressão de SHH, SUFU e MCM3. No CME, observou-se alta expressão de SHH, GLI1, SUFU e HHIP e baixa expressão de STAT3 e MCM3. Quando comparado entre os tipos tumorais, observou-se diferença estatisticamente significante para expressão de SHH (p=0.0064), STAT3 (p=0.0003) e MCM3 (p=0.0257)...

The pleomorphic adenoma (PA), mucoepidermoid carcinoma (MEC) and the adenoid cystic carcinoma (ACC) are common tumors arising from salivary glands. The Sonic Hedgehog signaling pathway (Hh) and signal transducer and activator of transcription 3 (STAT3) play important roles in cell proliferation, favoring tumor growth. The MCM3 protein has been considered as a novel class of cell proliferation markers. The aim of this investigation was to study components of the Hh pathway, as well as STAT3 and MCM3 in salivary gland neoplasms in an attempt to add information about the biological characteristics of these neoplasms. We used 9 cases of PA, 17 cases of ACC and 20 cases of MEC. Using immunohistochemistry, were investigated: SHH, GLI1, Sufu, HHIP, STAT3 and MCM3. In PA, there was high expression of cytoplasmic SHH and Sufu, and low expression of STAT3 and MCM3. In the ACC, there was high expression of GLI1, HHIP and STAT3 and low expression of SHH, SUFU and MCM3. In the MEC, we observed high expression of SHH, GLI1, SUFU and HHIP and low expression of STAT3 and MCM3. There was a statistically significant difference between SHH (p=0.0064), STAT3 (p=0.0003) and MCM3 (p=0.0257) when all tumors were compared...

clinico-pathologic study of 82 intraoral minor salivary gland tumors

Intraoral minor salivary glands tumors [MSGT] are uncommon, with geographic variations in frequency and distribution. This study analyzed the clinic-pathologic features of these tumors in Shiraz, southern Iran. All of cases histopathologically recorded as epithelial MSGT in Pathology Department of Khalili Hospital from 2002 to 2009 were evaluated with regard to patient's age and gender, tumor location and type, retrospectively. Out of 82 cases of MSGT, 53.7% were benign and 46.3% were malignant. Pleomorphic adenoma and adenoid cystic carcinoma were the most common benign and malignant tumors, respectively. The palate was the most common site of involvement [64.6%]. Male to female ratio was 1:1.27. The mean age of the patients was 35.0 +/- 17.2 years for benign and 48.8 +/- 18.2 years for malignant tumors. MSGTs in the present study represent many characteristics of other studies. However, our patients who were affected by benign tumors were young

Cáncer laríngeo de histología inhabitual / Unusual histology laryngeal cancer

Introducción: El cáncer laríngeo en 95 por ciento de los casos corresponde a carcinomas escamosos, siendo el porcentaje restante de diversos tipos histológicos. Objetivo: Determinar la frecuencia de cáncer laríngeo de histología inhabitual en nuestro centro. Material y método: Estudio retrospectivo, revisión de fichas clínicas de pacientes con diagnóstico histopatológico de cáncer laríngeo evaluados en el Servicio Otorrinolaringología Hospital San Juan de Dios, entre años 2000-2008. Se describen sexo, edad, tipo histológico, hábito tabáquico y localización tumoral, realizándose un análisis descriptivo de los datos. Resultados: Se incluyeron 85 pacientes; 74 casos (87,1 por ciento) de sexo masculino; promedio edad 64 años; se encontraron 5 casos de tumores de histología inhabitual (5,9 por ciento); un caso respectivamente de: condrosarcoma, tumor carcinoide, carcinoma adenoideo-quístico, carcinoma sarcomatoide y carcinoma verrucoso. Discusión: Se podría sospechar histología inhabitual con base estadística ante un paciente menor de 60 años y con un tumor de localización subglótica. Además, sexo femenino, no fumador y más de una toma de muestra para biopsia. Conclusión: Los tumores de histología inhabitual se encontraron en 5,9 por ciento de los casos, similar a lo reportado en la literatura.

Introduction: The laryngeal cancer in 95 percent of the cases corresponds to squamous cell carcinomas, being the remaining percentage several histological different types. Aim: To determine the frequency of laryngeal cancer of unusual histology in our center. Material and method: Retrospective study review of clinical data of patients with histophatological diagnosis of laryngeal cancer evaluated in Otolaryngology Department ofSan Juan de Dios's Hospital between years 2000-2008. Sex, age, histological type, tobacco smoking and tumor location are described, being carried outa descriptive analysis ofthe data. Results: 85 patients were included; 74 cases (87,1 percent) ofmasculine sex; mean age 64 years; there were 5 cases of unusual histology tumors (5,9 percent); a case respectively of: chondrosarcoma, carcinoid tumor, adenoid-cystic carcinoma, sarcomatoid carcinoma and verrucous carcinoma. Discussion: It might suspect unusual histology with statistical base in patient younger than 60 years and tumor of subglotic location. Also, in feminine patient, not smoking and more than one capture ofsample forbiopsy Conclusion: The tumors of unusual histology viere found in a 5.9 percent of the cases, similar to the reponed in the literature.

Tumores de tráquea: un caso de carcinoma adenoideo quístico / Tracheal tumors: a case of adenoidal cystic carcinoma

Los tumores de la tráquea son poco frecuentes y entre ellos el carcinoma adenoideo quístico es una neoplasia muy rara. La incidencia no difiere según el sexo y es más frecuente entre la tercera y quinta décadas de la vida. El tratamiento de elección es el quirúrgico, siempre que se trate de tumores resecables. Con este trabajo presentamos un caso intervenido por un tumor traqueal infrecuente, en una mujer con un carcinoma adenoideo quístico del tercio superior de la tráquea, con bordes de sección libres de tumor, que no recibió tratamiento oncológico(AU)

The tumors of the windpipe are not very frequent and among them the cystic adenoid carcinoma is a very strange neoplasia. The incidence doesn't differ according to the sex and it is more frequent between the third and fifth decades of the life. The election treatment is the surgical one, whenever it is tumors resecables. With this work we present a case intervened by an uncommon tracheal tumor, in a woman with a cystic adenoid carcinoma of the superior third of the windpipe, with section borders free of tumor that didn't receive treatment oncológico(AU)

Carcinoma adenoide quístico de glándula sublingual: combinación de cirugía y radioterapia / Cystic adenoid carcinoma of sublingual gland: surgery and radiotherapy combination

El carcinoma adenoide quístico (CAQ) o cilindroma es una rara entidad clasificada por la OMS dentro de los carcinomas de glándulas salivales. Representa sólo el 1 por ciento de todos los tumores malignos de la región bucal y maxilofacial, aunque al hacer referencia a las glándulas salivales, constituye el 5 por ciento de los carcinomas de parótida, submaxilar y sublingual, y aproximadamente el 50 por ciento de las menores. La ubicación más frecuente es en las glándulas palatinas y sus características principales son: crecimiento lento pero persistente, altas tasas de recidiva local y metástasis a distancia, originando la muerte dentro de los 5 a 10 primeros años en aproximadamente el 50-70 por ciento de los casos. Se presenta un caso de localización en glándula sublingual, el cual fue tratado quirúgicamente con posterior radioterapia, obteniendo buenos resultados

Perfil epidemiológico das neoplasias de glândulas salivares: análise de 245 casos

OBJETIVO: este trabalho tem por objetivo determinar a freqüência relativa e a distribuição das neoplasias epiteliais benignas e malignas de glândulas salivares. FORMA DE ESTUDO: Coorte histórica. MATERIAL E MÉTODO: registradas no Laboratório de Patologia e Citologia, em Aracaju-SE, no período de janeiro de 1980 a dezembro de 1999, considerando-se as variáveis sexo, idade, tipo racial, localização anatômica e diagnóstico histopatológico. RESULTADO: Dos 162.312 casos registrados, 245 (0,15 por cento) foram de neoplasias epiteliais de glândulas salivares, sendo 187 de natureza benigna (76,33 por cento) e 58 (23,67 por cento) malignas. O adenoma pleomórfico foi o tumor benigno mais identificado (89,94 por cento) e o carcinoma adenóide cístico foi o representante maligno mais prevalente (22,41 por cento). As neoplasias benignas ocorreram principalmente entre as 2° e 3° décadas de vida, exibindo predileção pelo sexo feminino, enquanto as malignas foram diagnosticadas entre as 6° e 7° décadas de vida, sendo as mulheres o principal alvo. CONCLUSÃO: Constatou-se que o padrão epidemiológico das neoplasias estudadas está em consonância com a maioria da literatura pesquisada.

Malignant salivary gland tumors

El objetivo de este trabajo fue conocer la frecuencia relativa de los tumores malignos de glándulas salivales en una población mexicana y compararla con datos previamente publicados de poblaciones latinoamericanas y no latinoamericanas. Se revisaron los archivos del Servicio de Diagnóstico en Patología Bucal y Maxilo-Facial de la Facultad de Odontología, UNAM de 1962 a 1997. Durante ese lapso se procesaron 9,639 biopsias de las cuales el 6.1 por ciento fueron lesiones o tumores de glándulas salivales, de éstas, 75 casos fueron neoplasias y de ellas, 26 casos correspondieron a carcinomas. De los 26 casos, el 50 por ciento fueron carcinomas mucoepidermoides, el 31 por ciento carcinomas adenoideos quísticos, 7.7 por ciento fueron adenocarcinomas NOS y 11.3 por ciento de otros carcinomas. Estos carcinomas fueron más frecuentes entre la 5º y 7º décadas de la vida y aparecieron con mayor frecuencia en el paladar, seguido por el área retromolar y el piso de la boca. El promedio de edad fue de 44.3 años y no se observó diferencia significativa por sexo (relación hombre:mujer de 1.1:1). Se observaron algunas diferencias con reportes previos. Nuestros resultados junto con otros de países latinoamericanos, sugieren que las diferencias con poblaciones no Latinoamericanas se deben a factores genéticos o étnicos.

Cilindromatose: atualizaçäo clínica e epidemiológica / Cylindromatosis: clinical and epidemiological up-date

A proposta deste trabalho é fornecer uma revisäo e informaçöes atualizadas sobre a síndrome conhecida como cilindromatose ou tumor em turbante. A cilindromatose é uma desordem genética autossômica dominante que possui duas formas de manifestaçäo, uma de origem hereditária e a outra esporádica. A clínica se baseia no surgimento de tumores oriundos das glândulas sudoríparas écrinas que tendem a se concentrar na cabeça, principalmente, couro cabeludo e pescoço.

Bronchial adenoma--an eleven-year experience.

Thirteen patients with bronchial adenoma were investigated. Most of these were young males and had recurrent hemoptysis and chest infection. Radiographs of the chest were abnormal in 11 patients. The tumor was visualized by fiberoptic bronchoscopy in all but one patient. The procedure was safe and none of the patients had massive hemoptysis following bronchoscopic biopsy. Limited follow-up revealed good results following surgery.