Résumé
No abstract available.
Sujets)
Humains , Mâle , Adulte d'âge moyen , Marqueurs biologiques tumoraux/analyse , Biopsie , Carcinosarcome/composition chimique , Chimioradiothérapie adjuvante , Issue fatale , Immunohistochimie , Tumeurs du poumon/composition chimique , Plancher de la bouche/composition chimique , Tumeurs de la bouche/composition chimique , Pneumonectomie , Facteurs temps , Tomodensitométrie , Résultat thérapeutiqueRésumé
Sarcomatoid carcinoma is a rare biphasic tumor characterized by a combination of malignant epithelial and mesenchymal cells. We report a rare case of sarcomatoid carcinoma of the colon. A 41-yr-old woman was hospitalized with a history of melena. Total colectomy was performed under the impression of colonic carcinoma. Histologically, the tumor was composed of differentiated adenocarcinoma in superficial portion and sarcomatoid spindle cells in deeper portion with a transitional area between the two portions. The sarcomatous areas revealed polygonal and spindle-shaped anaplastic malignant cells arranged in sheet, short fascicular or haphazard pattern. Immunohistochemically, tumor cells showed a positive immunoreaction for cytokeratin, epithelial membrane antigen, and vimentin. The histopathological and immunohistochemical transitions between the adenocarcinoma area and the spindle cell area suggested that the sarcomatous elements originated from the adenocarcinoma during tumor progression.