The topical treatment of old world cutaneous leishmaniasis with gentian violet along with cryotherapy: a pilot single-blind randomized controlled clinical trial

Abstract INTRODUCTION: The promising non-clinical antileishmanial effects of gentian violet (GV) encouraged us to evaluate the additive effect of GV on cryotherapy. METHODS: For 8 weeks, 59/161 cutaneous leishmaniasis patients/lesions underwent cryotherapy alone (group 1) or cryotherapy accompanied by 1% GV application (group 2). The primary endpoint was clinical response. RESULTS: Ultimately, 54.7% and 45.3% of the significantly cured lesions belonged to groups 1 and 2, respectively, which was not statistically significant. The clinical response was significantly different between the two groups at the end of the fourth week. CONCLUSIONS: Although the clinical response of the two groups was significantly different at the end of the fourth week, application of GV did not increase the efficacy of cryotherapy.

Caso clínico: un tratamiento alternativo a la parotiditis crónica / Clinical case: an alternative treatment for chronic parotitis

La parotiditis crónica conocida también como parotiditis juvenil recurrente, se define como la inflamación recurrente de la glándula parótida, asociada a la aparición de sialectasias o dilataciones no obstructivas de los conductos glandulares. Como tratamiento se emplea habitualmente la sialografía que tiene una tasa de éxito que va de 62 por ciento a 94 por ciento. Se presenta aquí un caso de un niño de 4 años de edad con parotiditis crónica, que persiste con episodios de parotiditis, pese a la realización de dos sialografías con un intervalo de 1 año entre ambas. Se decide inyectar violeta genciana, procedimiento que no tuvo complicaciones, después de la inyección remitió la enfermedad

Chronic parotitis, also known as juvenile recurrent parotits, is defined as the recurrent inflammation of the parotid gland, associated to the appearance of sialectasis or non-obstructive dilation of the glandular ducts. Sialography is regularly employed as a treatment, with success rates ranging between 62 and 94 percent. Here we present the case of a 4 year old child with chronic parotitis, that persisted with parotitis episodes despite having two sialographies performed, with one year interval between them. We decided to inject methyl violet, a procedure that was carried out without any complications; and the disease resolved shortly after the injection

Hemorrhagic Cystitis due to Intravesical Instillation of Gentian Violet Completely Recovered with Conservative Therapy

Chemical cystitis due to intravesical instillation of gentian violet or crystal violet is rare and all of the reported cases have been in adults using undiluted solution, which resulted in long-term sequelae. This is a case report on a 16-month-old boy with hemorrhagic cystitis after the instillation of diluted gentian violet into the bladder to rule out bladder injury during inguinal herniorrhaphy. Although he was completely recovered with conservative therapy, gentian violet, even when diluted, should not be used on the urinary tract.

Infiltraçäo de corante em obturaçöes de canais radiculares em funçäo de cimentos e tempos de imersäo / Marginal leakage at the interface root canal/filling using different cements and immersion times

O canal radicular de 160 dentes foi obturado com OZE ou Sealapex. Após a impermeabilizaçäo radicular eles foram imersos em azul de metileno a 2 por cento, fluoresceína a 2 por cento, violeta de genciana a 2 por cento e rhodamina B a 1 por cento, onde permaneceram por 24 ou 168 horas. Foram a seguir, secionados longitudinalmente, procedendo-se as leituras específicas da microinfiltraçäo. As maiores magnitudes de infiltraçäo foram observadas com a fluoresceína e a rhodamina B, seguindo-se o azul de metileno e a violeta de genciana, sendo que o azul de metileno apresentou a menor variedade e a fluorescína a maior. O cimento Sealapex mostrou-se melhor selador que o OZE