1.
Indian J Physiol Pharmacol
;
1997 Apr; 41(2): 171-5
Article
Dans Anglais
| IMSEAR
| ID: sea-108776
Résumé
Inclusion complex of plumbagin was prepared with betacyclodextrin employing neutralization method. The toxicity of the drug was reduced and the antitumor efficacy was enhanced on complexation with betacyclodextrin.
Sujets)
Absorption , Analyse de variance , Animaux , Antinéoplasiques d'origine végétale/administration et posologie , Cancérogènes/métabolisme , Carcinome d'Ehrlich/traitement médicamenteux , Cyclodextrines/métabolisme , Relation dose-effet des médicaments , Vecteurs de médicaments , Synergie des médicaments , Femelle , Dose létale 50 , Souris , Souris de lignée BALB C , Naphtoquinones/administration et posologie , Transplantation tumorale , Cyclodextrines bêta
2.
Indian J Biochem Biophys
;
1991 Aug; 28(4): 247-51
Article
Dans Anglais
| IMSEAR
| ID: sea-28306
Résumé
Cu(2+)-beta-cyclodextrin (1:1) complex has been found by UV, fluorescence and CD spectroscopy, polarimetry and gel electrophoresis to bind reversibly to calf thymus DNA. Using UV the binding constant was found to be 45280 +/- 7100 M-1. The binding of the complex Cu(2+)-BCD with DNA was stronger than that of free Cu2+. However the ternary complex formed thus was destroyed by EDTA.