Résumé
The authors report an 11-year-old boy with septicemia and subacute infective endocarditis due to toxigenic-Corynebacterium diphtheriae. The patient had underlying congenital heart disease and incomplete immunization. He presented with fever, epistaxis and congestive heart failure. He received high-dose penicillin therapy and diphtheria antitoxin with clinical improvement. While he was receiving a high dose of penicillin for 1 month he developed a generalized tonic clonic seizure. A computerized tomogram revealed intracerebral and ventricular hemorrhage. Craniotomy with blood clot removal and ventriculostomy drainage were done. He died 2 days later from brain death and cardiovascular failure.
Sujets)
Enfant , Corynebacterium diphtheriae/isolement et purification , Diphtérie/étiologie , Endocardite bactérienne/microbiologie , Issue fatale , Humains , MâleSujets)
Humains , Nouveau-né , Nourrisson , Enfant d'âge préscolaire , Enfant , Diphtérie , Infections bactériennes à Gram positif , Pédiatrie , Corynebacterium diphtheriae , Diagnostic différentiel , Diphtérie/diagnostic , Diphtérie/épidémiologie , Diphtérie/étiologie , Diphtérie/histoire , Diphtérie/anatomopathologie , Diphtérie/thérapie , ImmunothérapieRésumé
A difteria, embora seja uma das doenças melhor estudadas atualmente, ainda ameaça a populaçao brasileira. A imunizaçao deficiente e a falta de informaçao das equipes médicas em relaçao à sua incidência dificultam o diagnóstico e o tratamento. Os autores discutem a situaçao epidemiológica brasileira e os novos métodos diagnósticos, preciosos e de baixo custo, realizados pelos laboratórios centrais de Saúde Pública.