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Journal of Forensic Medicine ; (6): 30-32, 2010.
Article Dans Chinois | WPRIM | ID: wpr-983534

Résumé

OBJECTIVE@#To study the relation between human blood estazolam concentration and neurobehavioral function.@*METHODS@#The neurobehavioral ability of 10 volunteers were measured with computer-administered neurobehavioral evaluation system-chinese3 (NES-C3) and SMART EquiTest system.@*RESULTS@#The neurobehavioral ability and balance function declined 1 h later after dosing estazolam. The neurobehavioral ability index and balance function declined to the lowest level 3 h later after dosing estazolam. The neurobehavioral ability recovered partly 6 h later after dosing estazolam, and neurobehavioral ability recovered completely 10 h later.@*CONCLUSION@#Driving ability was impaired when estazolam concentration in blood is 20 ng/mL, and the neurobehavioral ability declined when estazolam concentration is 40 ng/mL in blood. The influence to human in absorption process is greater than the metabolic process with the same estazolam concentration.


Sujets)
Adulte , Femelle , Humains , Mâle , Accidents de la route/prévention et contrôle , Administration par voie orale , Anticonvulsivants/pharmacocinétique , Attention/effets des médicaments et des substances chimiques , Comportement/effets des médicaments et des substances chimiques , Estazolam/pharmacocinétique , Tests neuropsychologiques , Performance psychomotrice/effets des médicaments et des substances chimiques , Temps de réaction
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