Résumé
Introduction: Recently, some studies have reported accumulation of gadolinium in the brain of patients with multiple administrations of gadolinium-based contrast. Patients with multiple sclerosis are subjected to multiple contrasting resonances and could become a population at risk. Objective: To determine whether repeated intravenous exposure to gadolinium is associated with more intensity in the thalamus, dentate nucleus, pons and the globus pallidus. Methods: A retrospective study of 60 patients with MS who had undergone two or more contrasted MRs between 2007 and 2015, was performed. The ratios calculated were: dentate nuclei-to-pons (DNP), thalamus-to-pons (TP), caudate nuclei-to-pons (CNP), globus pallidus-to-thalamus (GPT), globus pallidus-to-pons (GPP), by reviewing simple T1 axial sequences. Relative changes were calculated and compared with the number of contrasted MRs. The concordance between observers and the intraclass correlation coefficient was evaluated. Results: There was no evidence of increased signal intensity in T1 sequences (DNP 0.524, GPT 0.466, GPP 0.684, TP 0.771, CNP 0.352). As there were no differences, the Spearman coefficient showed no correlation between relative changes and the number of resonances performed. Inter-observer agreement was almost perfect (0.982) for all structures. Conclusion: Our study did not find a statistically significant increase in the T1 signal intensity in patients with multiple sclerosis. However, there are factors to consider, such as the type of gadolinium and the time lapse between administrations.
Introducción: Recientemente, algunos estudios han informado acumulación de gadolinio en el cerebro de los pacientes con múltiples administraciones de contraste basado en gadolinio. Los pacientes con esclerosis múltiple son sometidos a múltiples resonancias contrastadas y podrían convertirse en una población de riesgo. Objetivo: Determinar si la exposición repetida por vía intravenosa a gadolino se asocia con mayor intensidad en el tálamo, el dentado, el puente y el globo pálido. Métodos: Se realizó un estudio retrospectivo núcleo de 60 pacientes con EM que habían sido sometidos a dos o más RM contrastadas entre 2007 - 2015. Se calcularon las razones núcleo dentado - puente (DNP), tálamo-puente (TP), núcleo caudado- puente (CNP), globus pallidus - tálamo (GPT), globus pallidos - puente (GPP), revisando secuencias T1 axiales simples. Se calcularon los cambios relativos y se compararon con el número de RM contrastadas. Se evaluó la concordancia entre observadores con el coeficiente de correlación intraclase. Resultados: No hubo evidencia de aumento de la intensidad de la señal en secuencias T1 (DNP 0,524, 0,446 GPT, GPP 0,684, 0,771 PT, CNP 0.352). Al no existir diferencias, el coeficiente de Spearman no mostró correlación entre los cambios relativos y el número de resonancias realizadas. La concordancia interobservador fue casi perfecta (0.982) para todas las estructuras. Conclusión: Nuestro estudio no encontró un aumento estadísticamente significativo en la intensidad de la señal T1 en pacientes con esclerosis múltiple. Sin embargo, hay factores a considerar, tales como el tipo de gadolinio y el lapso de tiempo entre las administraciones.
Sujets)
Humains , Mâle , Femelle , Adulte , Adulte d'âge moyen , Produits de contraste/administration et posologie , Acide gadopentétique/administration et posologie , Sclérose en plaques/diagnostic , Noyaux du cervelet/anatomopathologie , Globus pallidus/anatomopathologie , Imagerie par résonance magnétique , Sclérose en plaques/anatomopathologie , Études rétrospectives , Thalamus/anatomopathologieRésumé
Bilateral and symmetric globus-pallidus hyperintensities are observed on T1-weighted MRI in most of the patients with chronic liver failure, due to manganese accumulation. We report a 53-year-old man, with rapid onset parkinsonism-dementia complex associated with accumulation of manganese in the brain, secondary to liver failure. A brain MRI was performed and a high signal on T1-weighted images was seen on globus-pallidus, as well as on T2-weighted images on the hemispheric white-matter. He was referred to a liver-transplantation. The patient passed away on the seventh postoperative day. Our findings support the concept of the toxic effects of manganese on the globus-pallidus. The treatment of this form of parkinsonism is controversial and liver-transplantation should not be considered as first line treatment but as an alternative one.
Hiperintesidades simétricas e bilaterais dos gânglios da base são observadas em imagens de ressonância magnética encefálica (RM) ponderadas em T1 na maioria dos pacientes com insuficiência hepática crônica devidas ao acúmulo de manganês. Nós relatamos o caso de um homem, com 53 anos de idade, com um complexo parkinsonismo-demência rapidamente progressivo associado com o acúmulo de manganês no cérebro, secundariamente a insuficiência hepática. Uma RM encefálica foi realizada e foram observadas imagens hiperintensas/hipersinal nas imagens ponderadas em T1 no globo pálido e, também, na substância branca dos hemisférios cerebrais ponderadas em T2. Devido à falta de resposta ao tratamento clinico optamos pelo transplante hepático. O paciente faleceu no 7° dia de PO. Nossos achados corroboram o conceito dos efeitos tóxicos do manganês nos gânglios da base/globo pálido. O tratamento desta forma de parkinsonismo é controverso e o transplante hepático não deverá ser considerada uma opção terapêutica de primeira linha, porém como um tratamento alternativo considerando-se os riscos-benefícios dessa escolha.
Sujets)
Humains , Mâle , Adulte d'âge moyen , Démence/chirurgie , Transplantation hépatique , Défaillance hépatique/chirurgie , Intoxication au manganèse/complications , Syndrome parkinsonien secondaire/chirurgie , Démence/induit chimiquement , Démence/anatomopathologie , Issue fatale , Globus pallidus/anatomopathologie , Globus pallidus/chirurgie , Défaillance hépatique/complications , Imagerie par résonance magnétique , Syndrome parkinsonien secondaire/induit chimiquement , Syndrome parkinsonien secondaire/anatomopathologieRésumé
We describe a child with pathologically proven Hallervorden Spatz disease. He presented with extrapyramidal symptoms and characteristic "eye-of-the-tiger" sign on magnetic resonance imaging. He was given the possible benefit if any of deep brain stimulation with no much improvement. Pathological examination of the brain showed iron deposition in bilateral globus pallidi, spongiform change and neuron axonal degeneration (spheroids).
Sujets)
Enfant , Issue fatale , Globus pallidus/anatomopathologie , Humains , Imagerie par résonance magnétique , Mâle , Neurodégénérescence associée à la pantothénate kinase/anatomopathologieRésumé
Acute mountain sickness (AMS) occurs commonly in hikers who are rapidly exposed to high altitude environments. Despite the numerous reports of AMS, few studies have reported pallidal lesions associated with altitude sickness. A previously healthy 49-yr-old Korean patient, after ascent to 4,700 m, suffered symptoms consistent with AMS. After returning home, the patient showed changes in personality characterized by abulia, indifference, and indecisiveness. T2 weighted brain magnetic resonance imaging showed high signal lesions involving bilateral globus pallidus. Our case suggests that globus pallidus injury should be included in the differential diagnosis of patients with personality or cognitive change after recovery from AMS.
Sujets)
Humains , Mâle , Adulte d'âge moyen , Altitude , Mal de l'altitude/complications , Comportement , Encéphale/anatomopathologie , Souffrance cérébrale chronique/étiologie , Environnement , Globus pallidus/anatomopathologie , Imagerie par résonance magnétique , AlpinismeRésumé
Three patients were diagnosed as suffering from Hallervorden Spatz disease, a rare disorder, on the basis of their clinical and MRI findings.
Sujets)
Adulte , Enfant , Femelle , Globus pallidus/anatomopathologie , Humains , Imagerie par résonance magnétique , Mâle , Neurodégénérescence associée à la pantothénate kinase/diagnosticRésumé
Relata-se o caso de uma paciente com quadro parkinsoniano instalado aos 26 anos de idade, 30 anos de evoluçäo, boa reposta à levodopa e desenvolvimento precose de discinesias induzidas por essa droga. Essas características associadas à ausência de outras manifestaçöes neurológicas ao longo de todo o curso da moléstia sugeriam substrato anátomo-patológico superponível ao da forma clássica da doença de Parkinson. Entretanto, as imagens de ressonância magnética mostraram lesöes palidais do tipo "eye-of-the-tiger", semelhantes às observadas na doença de Hallervorden-Spatz. O presenta caso ilustra a heterogeneidade patológica dos casos de parkinsonismo de instalaçäo precoce e a possibilidade do encontro desse padräo de lesöes palidais em outras doenças degenerativas dos gânglios da base
Sujets)
Humains , Femelle , Adulte d'âge moyen , Syndrome parkinsonien secondaire/diagnostic , Imagerie par résonance magnétique , Diagnostic différentiel , Globus pallidus/anatomopathologie , Neurodégénérescence associée à la pantothénate kinase/diagnosticRésumé
Relata-se um caso de encefalopatia de Wernicke que ocorreu em paciente masculino de 38 anos, como complicaçäo de alimentaçäo parenteral total. Houve boa recuperaçäo clínica com suplementaçäo de tiamina mas, como complicaçäo neurológica tardia, o paciente desenvolveu quadro amnésico associado a síndrome de lobo frontal caracterizada por apatia, perseveraçäo e alteraçäo de testes de funçäo cortical frontal. TC revelou presença de lesöes bilaterais de globo pálido. Säo discutidos alguns aspectos relacionados ao desenvolvimento de síndromes corticais frontais em decorrência de lesöes estruturais subcorticais