Résumé
Administration of aqueous extract of T. aestivum (200 and 400 mg/kg/day, po, for 30 days) and risedronate (20 mg/kg, sc, five times a week for 30 days) following methyl prednisolone sodium succinate (10 mg/kg, sc, thrice a week for 4 weeks) induced osteoporosis in Wistar rats showed an increase in the serum levels of bone mineral content markers, decrease in the serum and urinary levels of bone resorption markers. An incline in strength of femur and tibia was seen particularly with 400 mg/kg of T. aestivum. Maintenance of calcium homeostasis, formation of collagen and scavenging of free radicals can plausibly be the mode of action of aqueous extract of T. aestivum thereby combating osteoporosis induced by glucocorticoids.
Sujets)
Animaux , Densité osseuse/effets des médicaments et des substances chimiques , Résorption osseuse/traitement médicamenteux , Résorption osseuse/métabolisme , Collagène/biosynthèse , Acide étidronique/administration et posologie , Acide étidronique/analogues et dérivés , Fémur/effets des médicaments et des substances chimiques , Fémur/métabolisme , Piégeurs de radicaux libres/administration et posologie , Glucocorticoïdes/toxicité , Mâle , Ostéoporose/induit chimiquement , Ostéoporose/traitement médicamenteux , Ostéoporose/anatomopathologie , Extraits de plantes/administration et posologie , Extraits de plantes/composition chimique , Prednisolone/administration et posologie , Rats , Tibia/effets des médicaments et des substances chimiques , Tibia/métabolisme , Triticum/composition chimiqueRésumé
Administration of 3 mg/kg body weight of dexamethasone from day 1 or 3 to 7 of pregnancy did not prevent implantation in albino rats. But the same dose when administered from day 8 to 11 resulted in complete abortion / resorption in all rats. Administration of 2 mg / kg body weight of dexamethasone from day 8 to 11 of pregnancy held no effect on the foetal survival. The results indicate that a high dose of dexamethasone does not affect implantation but the same dose affects the more advanced stages of pregnancy.