HPTLC method for estimation of Olmesartan medoxomil in tablet formulation with stability studies

A rapid resolution high performance thin layer chromatography [HPTLC] method has been developed and validated for estimation of Olmesartan medoxomil in tablet formulations. This paper describes accurate, precise, specific and reproducible method and its degradation products, related impurities for assessment of purity of bulk drug and stability of its tablet formulations. The method involve silica gel 60 F[254] high performance thin layer chromatography and densitometric detection at 264 nm using toluene - acetonitrile- methanol - ethyl acetate - acetic acid [5:3.5:0.3:1:0.3 v/v/v/v]. Calibration curve ranges between 300-800 ng/spot-1 Olmesartan medoxomil. Experimental design was involved forced degradation of drug, optimization' of mobile phase, detection made and other chromatographic phase and study of linearity range. The total time for chromatographic separation was 6 min with a total analysis time 15 min. The proposed method was validated for its linearity, precision, recovery studies and robustness

novel synthesis of imidazoquinazolinone and gly cocyamidine derivatives

2-diphenyl imidazo [2,3-b] quinazoline-3,5-dione [3] was obtained smoothly from the reaction of 2-alkylmercapto-5-5-diphenyl hydantoins [2a,b] with anthranilic acid. The reaction of 5-ylidene-2-alkylmercapto hydantoins [6a-h] reacted with aniline and hydrazine hydrates to get finally the glycocyamidine derivatives

Role of monoxide [CYNT] in migraine

This study is aimed at investigating the possibility of effectiveness of moxonicdine, new centrally acting [imidazoline receptor agonist] anti-hypertensive agent in patients with migraine. Twenty seven patients of migraine between ages 1952 years were recruited on the basis of- poorly controlled headache while taking maximum tolerated dose of traditional medication. In this open study, subjects were given moxonidine while they continued the previous medication. Consumption of analgesic [Paracetamol] tablets per week was used as an indicator of the degree of control of the migraine headache. Our results showed significant reduction in the headaches related to migraine; as assessed by the consumption of analgesic tablets, over the studied period in moxonidine treated group of patient as compared to the control group

Reactions with hydrazonoyl halides, XVIII: synthesis of pyrolidino [3,4-c] pyrazole, pyrazolo [3,4-d] pyridazine, imidazo [1,2-a] pyrimidine, pyrasolo [3,4-d] pyrimidine and other heterocyclic derivatives

A synthesis of 1,4-benzothiazine, 1,4-benzoxazine, 1,4-quinoxaline, imidazo[1,2-a] pyridine, imidazol [1,2-a] pyrimidine and pyrazole derivatives was accomplished from the reaction of hydrazonoyl bromide I with 2-aminothiophenol, 2-aminophenol, 1,2-phenylenediamine, 2- aminopyridine, 2-aminopyrimidine and some active methylene. Also, compound 1 reacted with some dipolorophile to give pyrazolines and pyrrolidino [3,4-c] pyrazolines. All structures were elucidated on the basis of elemental analyses and spectral data

Acropaquia tiroidea / Thyroid acropachy

Se presenta una paciente con exoftalmia, mixedema pretibial e infiltración de los dedos de las manos que en el extremo distal adoptan la forma de palillo de tambor con uñas en vidrio de reloj. Sa analizan las características clínicas, histopatológicas y radiológicas y se efectúa una revisión de la literatura de este raro síndrome