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Indian J Exp Biol ; 1992 Jul; 30(7): 583-6
Article Dans Anglais | IMSEAR | ID: sea-56077

Résumé

In line of the effort towards development of some newer indanyl non-steroidal anti-inflammatory agents and providing comprehensive SAR among this class of compounds some significantly active derivatives with low ulcerogenic potential were identified. Dealing with various long chain and branched chain compounds among this series, 3-(5, 6-dimethoxy indan-1-yl) propionic acid, 2-(5, 6-dimethoxy indan-1-yl) propionic acid and 3-(6-methoxy indan-1-yl) propionic acid were observed to have encouraging biological activity. Screening in various animal models of inflammation suggests their longer duration of action and lower ulcerogenic liability.


Sujets)
Animaux , Anti-inflammatoires non stéroïdiens/effets indésirables , Arthrite expérimentale/traitement médicamenteux , Température du corps/effets des médicaments et des substances chimiques , Relation dose-effet des médicaments , Oedème/traitement médicamenteux , Études d'évaluation comme sujet , Indanes/effets indésirables , Dose létale 50 , Mâle , Douleur/traitement médicamenteux , Ulcère peptique/induit chimiquement , Rats , Rat Wistar
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