Résumé
The anti-tumour effects of methoxyphenyl maleamic acid (MPMA) and cytotoxic drugs, in combination were investigated on P388 leukaemia and S180 (ascites) tumours. Simultaneous administration of MPMA with CTX or HN2 resulted in enhancement of anti-tumour activity. The increased activity was observed against P388 leukaemia, whereas S180 (ascites) tumour was not responsive to the combined treatment. The possible mechanism (s) of action, responsible for the modulation of activity of CTX and HN2 against P388 tumour have been postulated.
Sujets)
Animaux , Protocoles de polychimiothérapie antinéoplasique/usage thérapeutique , Ascites/traitement médicamenteux , Cyclophosphamide/administration et posologie , Synergie des médicaments , Leucémie P388/traitement médicamenteux , Maléates/pharmacologie , Chlorméthine/administration et posologie , SourisRésumé
El (1-[2-cloroetil] 1-nitroso, 3 ciclohexil urea) (CCNU) es una droga antitumoral que forma parte actualmente de múltiples esquemas de poliquimioterapia en el tratamienmto de diferentes localizaciones y su obtención en el país aumentará la disponibilidad de este producto. El presente trabajo evalúa la actividad, en comparación con el producto comercial usado actualmente en la clínica oncológica y por los resultados obtenidos en los tumores experimentales utilizados, ambos productos manifiestan semejante actividad antitumoral
Sujets)
Souris , Animaux , Protocoles de polychimiothérapie antinéoplasique/pharmacologie , Leucémie L1210/traitement médicamenteux , Leucémie P388/traitement médicamenteuxRésumé
Studies were carried out on the combination of Cimetidine (CMTD) with Cytoxan (CTX) in three murine tumors. While the combination significantly potentiated the anticancer effect of CTX in L1210 leukemia, the results with P388 leukemia were not significantly different. The results with Lewis Lung Carcinoma showed a consistent reduction in the number of metastases. However, there was no consistent concomitant prolongation in survival. The host strain, biology of the tumour and the drug used in combination with CMTD might be some of the factors responsible for the varied response.
Sujets)
Animaux , Cimétidine/administration et posologie , Cyclophosphamide/administration et posologie , Association de médicaments , Femelle , Leucémie L1210/traitement médicamenteux , Leucémie P388/traitement médicamenteux , Leucémie expérimentale/traitement médicamenteux , Tumeurs du poumon/traitement médicamenteux , Mâle , Souris , Souris de lignée DBA , Transplantation tumoraleRésumé
Los extractos etanólicos de 17 especies botánicas, fueron testados frente a los tumores experimentales leucemia P-388 y adenocarcinoma mamario 755. De estas especies, 16 pertenecen a la familia Rubiaceae y la restante a la familia Clusiaceae; 9 son endémicas. No se observó actividad antitumoralsignificativa de los extractos ensayados con las dosis administradas
Sujets)
Souris , Animaux , Adénocarcinome/traitement médicamenteux , Antinéoplasiques d'origine végétale/usage thérapeutique , Leucémie P388/traitement médicamenteux , Tumeurs expérimentales de la mamelle/traitement médicamenteux , Extraits de plantes/usage thérapeutiqueRésumé
Se estudió la actividad antitumoral del 1,3 biscloroetil nitrosourea (BCNU) sintetizado en Cuba en dos tumores transplantables de ratón, las leucemias L-1210 y P-388, así como la toxicidad de diferentes esquemas de administración del producto en ratas albinas. El producto aumentó notablemente la supervivencia de los animales tratados con respecto al control en los tumores experimentales usados y manifestó efectos tóxicos notables en el sistema hematopoyético y el hígado
Sujets)
Rats , Animaux , Femelle , Leucémie L1210/traitement médicamenteux , Leucémie P388/traitement médicamenteux , Nitrosourées/usage thérapeutique , Nitrosourées/toxicité , Transplantation tumoraleRésumé
Se estudia la actividad antitumoral de extractos etanólicos de plantas que crecen en Cuba en ratones con leucemia P-388 y leucemia 1210, se realiza un tamizaje alcaloidal para las mismas especies con el empleo de reactivos precipitantes y la cromatografía en placa delgada. Las plantas pertenecen a las familias Euphorbiaceae, Rubiaceae, Leguminoseae, Clusiaceae, Moraceae, Sapotaceae, Menispermeaceae y Sterculiaceae. Contienen alcaloides las especies Aleurites trisperma Blanco, Aleurites moluccana (L) Wiel, Pithecellobium dulce (Roxb) Benth, Tamarindus indica L., Chlorophora trinctoria L. Gaud e Hyperbaena racemosa Ukb. Tienen actividad antitumoral Chamaesyce buxifolia (Lam) Small, Andira inermis (Sw) H B K y Clusia rosea Jacq
Sujets)
Rats , Animaux , Antinéoplasiques d'origine végétale/usage thérapeutique , Leucémie L1210/traitement médicamenteux , Leucémie P388/traitement médicamenteux , CubaRésumé
The ability of Amphotericin B ('Fungizone') to alter the natural resistance of leukemia L1210 to vincristine was studied in BDF1 mice Neither Fungizone nor the "solubilizing agent" sodium deoxycholate, when used in combination with vincristine potentiated the activity of the drug against L1210. There was no change in the activity pattern of 5-fluorouracil against L1210 or vincristine against P388 lymphocytic leukemia respectively, which are sensitive to these drugs. Thus, both Fungizone and sodium deoxycholate failed to improve the activity of the drugs in either a naturally resistant or sensitive murine leukemia in vivo.
Sujets)
Amphotéricine B/administration et posologie , Animaux , Protocoles de polychimiothérapie antinéoplasique , Acide désoxycholique/administration et posologie , Calendrier d'administration des médicaments , Résistance aux substances , Synergie des médicaments , Fluorouracil/administration et posologie , Leucémie L1210/traitement médicamenteux , Leucémie P388/traitement médicamenteux , Leucémie expérimentale/traitement médicamenteux , Souris , Souris de lignée DBA , Transplantation tumorale , Vincristine/administration et posologieRésumé
The cytotoxic effects of acetylated oil of Semecarpus anacardium nuts on the cells of P388 lymphocytic leukemia were tested in vitro. The product was tested at the concentrations ranging from 15-75 micrograms/ml. The cell kill was observed as early as three hr after the treatment. The effects of acetylated oil on the biosynthesis of DNA, RNA and protein using labelled thymidine, uridine and leucine respectively showed that the product inhibited the biosynthesis of all the three. This was indicated by the inhibition of the incorporation of their precursors. The uptake of 3H-thymidine was inhibited 15 min after treatment; while that of 3H-uridine and 14C-leucine took 30 and 45 min respectively. Since the S. anacardium oil was unstable due to air-oxidation, the studies were confined to its acetylated product.
Sujets)
Acétylation , Animaux , Antinéoplasiques d'origine végétale , ADN tumoral/métabolisme , Femelle , Inde , Leucémie P388/traitement médicamenteux , Mâle , Souris , Souris de lignée DBA , Protéines tumorales/métabolisme , Huiles/pharmacologie , ARN tumoral/métabolisme , Facteurs tempsRésumé
Semecarpus anacardium Linn.f. nuts were extracted by using non-polar and polar organic solvents. Hot methanol extract and a resinous fraction, isolated from it, showed antitumour activity against P388 lymphocytic leukaemia in BDF1 mice as judged by their median survival time. Petroleum ether extract and its chromatographically isolated fraction were obtained. The latter fraction was distilled under reduced pressure to get an orange-coloured oil, (b.p. 200-20 degrees/2-3 mm). Both had antitumour activity. The orange-coloured oil, on further distillation under reduced pressure, yielded Bhilawanol. An acetyl derivative of the oil was also obtained. The latter two also had antitumour activity.