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2.
Saudi Medical Journal. 2011; 32 (4): 412-414
Dans Anglais | IMEMR | ID: emr-110133

Résumé

A rare but severe complication of Bacillus Calmette-Guerin [BCG] vaccination is the development of BCG disease, which can result in necrotizing granulomatous lymphadenitis. Symptoms can present as late as several months following the BCG vaccination. The key finding in BCG disease is the formation of caseating granulomas in draining lymph nodes; detection of BCG organisms from tissue samples are evident


Sujets)
Humains , Mâle , Femelle , Lymphadénite/induit chimiquement , Tuberculose/prévention et contrôle , Noeuds lymphatiques/anatomopathologie
3.
West Indian med. j ; 57(3): 302-306, June 2008. ilus, tab
Article Dans Anglais | LILACS | ID: lil-672367

Résumé

The immune reconstitution inflammatory syndrome (IRIS) is a recognized complication associated with opportunistic infections occurring in HIV-infected individuals after the initiation of highly active antiretroviral therapy (HAART). We report on three HIV-infected infants with rapid progressor HIV disease who present with IRIS due to the BCG vaccine and occurring 3-6 weeks after initiation of HAART.


El síndrome inflamatorio de la reconstitución inmune (SIRI) es una complicación reconocida asociada con infecciones oportunistas que ocurren en individuos infectados por el VIH, luego de su iniciación en la terapia antiretroviral altamente activa (TARAA). Se reporta el caso de tres infantes infectados por VIH con enfermedad VIH de progresión rápida, que se presentan con SIRI debido a la vacuna BCG, 3-6 semanas después de la iniciación de TARAA.


Sujets)
Femelle , Humains , Nouveau-né , Mâle , Adjuvants immunologiques/effets indésirables , Agents antiVIH/effets indésirables , Vaccin BCG/effets indésirables , Infections à VIH/traitement médicamenteux , Syndrome inflammatoire de restauration immunitaire/induit chimiquement , Lymphadénite/induit chimiquement , Agents antiVIH/usage thérapeutique , Antirétroviraux/effets indésirables , Antirétroviraux/usage thérapeutique , Vaccin BCG/immunologie , Infections à VIH/complications , Infections à VIH/transmission , Syndrome inflammatoire de restauration immunitaire/étiologie , Transmission verticale de maladie infectieuse , Jamaïque , Lymphadénite/microbiologie
4.
J Indian Med Assoc ; 2004 Dec; 102(12): 688-90, 692, 694
Article Dans Anglais | IMSEAR | ID: sea-99955

Résumé

The uneventful response to chemotherapy in leprosy is marked by clinically disturbing episodes encountered in 20-30% of patients and these phenomena are called "reactions". Generally they are classified as reversal reaction (type-1) and erythema nodosum leprosum (type-2). The cutaneous menifestations are: (1) Type-2 reactions in LL, BL types constituting erythema nodosum leprosum, erythema multiforme, erythema necroticans, subcutaneous nodules, lepromatous exacerbation. (2) Type-1 reactions in borderline and tuberculoid leprosy. The other manifestations include: Acute neuritis, lymphadenitis, arthritis, oedema of the hands and feet, ocular lesions, etc. Sequelae of reactions are: Paralytic deformities, non-paralytic deformities, extensive scarring and renal damage. A simple guideline to identify the risk-prone cases has been narrated. Prednisolone in standard dosage schedule as recommended by WHO is now being widely used in control programmes.


Sujets)
Arthrite/induit chimiquement , Cicatrice/induit chimiquement , Clofazimine/effets indésirables , Relation dose-effet des médicaments , Traitement médicamenteux/effets indésirables , Oedème/induit chimiquement , Érythème/induit chimiquement , Érythème noueux/induit chimiquement , Pied/anatomopathologie , Glucocorticoïdes/effets indésirables , Main/anatomopathologie , Humains , Hypersensibilité/étiologie , Immunosuppresseurs/effets indésirables , Lèpre/traitement médicamenteux , Lymphadénite/induit chimiquement , Névrite/induit chimiquement , Paralysie/induit chimiquement , Prednisolone/effets indésirables , Peau/effets des médicaments et des substances chimiques , Thalidomide/effets indésirables , Résultat thérapeutique
5.
Article Dans Anglais | IMSEAR | ID: sea-90037

Résumé

OBJECTIVES: Outbreaks are known to occur after Bacillus Calmette Guerin (BCG) vaccination. An outbreak of suppurative lymphadenitis in 18 infants, following BCG vaccination is reported from Sikkim, with incidence of 8.6%. The outbreak occurred after a change of vaccine. METHODS: In a prospective study the cases of suppurative lymphadenitis were diagnosed by needle aspiration cytology and culture of the material aspirated and managed only with repeated needle aspiration and no antitubercular treatment was given. RESULTS: Cytomorphology revealed necrosis alone in 66.6% and necrotizing granulomas in 22.2%. Acid and alcohol fast bacilli were detected in 77.7% cases. Mycobacterium bovis was isolated in eight cases. One case of staphylococcal suppurative lymphadenitis was detected. Sixteen cases were managed with weekly aspiration with mean period of resolution in eight weeks. CONCLUSIONS: Needle aspiration is useful in the diagnosis and effective in the management of these cases. No antitubercular treatment is desired and required in the cases of suppurative lymphadenitis following BCG vaccination.


Sujets)
Adjuvants immunologiques/effets indésirables , Vaccin BCG/effets indésirables , Ponction-biopsie à l'aiguille , Humains , Nourrisson , Lymphadénite/induit chimiquement , Suppuration/induit chimiquement
6.
Indian J Pediatr ; 1994 Sep-Oct; 61(5): 451-62
Article Dans Anglais | IMSEAR | ID: sea-83516

Résumé

With the extended programme of immunisation and since 1985 the universal programme of immunisation and the coverage status of BCG vaccination in India has been very good, although it is still unsatisfactory in the eastern states. It is emphasized that BCG vaccination cannot prevent natural tuberculous infection of the lungs and its local complications, although it reduces the haematogenous complications of primary infection. However, this is not true for malnourished children who, inspite of BCG vaccination, develop serious, and often fatal types of tuberculosis such as miliary, meningitic and disseminated tuberculosis. The tuberculin anergy in malnourished children, is mainly responsible for high morbidity and mortality. BCG vaccinated, well-nourished children manifest modified patterns of tuberculous disease, following infection. The most important manifestation is the increased incidence of intrathoracic tuberculosis, specially enlargement of the various groups of mediastinal nodes and their local complications. Localisation of the disease by T cell immunity, due to BCG vaccination is responsible for this and the much lower incidence of haemotological complications such as neurotuberculosis and disseminated disease. In these children, the clinical picture of neurotuberculosis is also modified, with a tendency for more localised involvement of the brain and meninges. Similarly, vaccinated children may present with hepatomegaly, splenomegaly or isolated organ disease. It is important to relearn the new patterns of tuberculosis disease seen in vaccinated, non-malnourished children, and to a lesser extent in children with grade 1 to 2 protein energy malnutrition (PEM). With these limitations of BCG vaccination, other strategies like chemoprophylaxis need multicentric trials in high risk children, in different parts of the country.


Sujets)
Vaccin BCG , Enfant , Troubles nutritionnels de l'enfant/complications , Enfant d'âge préscolaire , Pays en voie de développement , Infections à VIH/complications , Humains , Hypersensibilité retardée/complications , Programmes de vaccination , Rappel de vaccin , Incidence , Inde/épidémiologie , Nourrisson , Nouveau-né , Lymphadénite/induit chimiquement , Nébuliseurs et vaporisateurs , Test tuberculinique , Tuberculose pulmonaire/complications , Vaccination/effets indésirables
7.
Indian J Lepr ; 1986 Jan-Mar; 58(1): 73-8
Article Dans Anglais | IMSEAR | ID: sea-55174

Résumé

Eight out of 30 cases of Borderline Lepromatous and Lepromatous Leprosy suffering with chronic recurrent lepra reactions failed to respond to clofazimine therapy. Three of the eight were steroid dependent. All the eight patients are doing well after weaning off the clofazimine. Lymphadenitis in post clofazimine reactional status was presenting feature in present retrospective study.


Sujets)
Adulte , Clofazimine/effets indésirables , Érythème noueux/traitement médicamenteux , Femelle , Humains , Lèpre/traitement médicamenteux , Lymphadénite/induit chimiquement , Mâle , Études rétrospectives
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