Análise de parâmetros bioquímicos séricos e urinários em atletas de meia maratona / Biochemist plasmatic and urinary parameters analisys in marathon athletes

OBJETIVO: O objetivo do presente estudo foi analisar marcadores bioquímicos como marcadores de desempenho atlético, à luz de um contexto clínico e atlético. MÉTODOS: Foram coletadas amostras de sangue periférico (8 mL) e de urina (50 mL) de 20 maratonistas profissionais em repouso e 15 minutos após meia maratona. Em seguida, realizaram-se hemograma, exame de urina e análise de marcadores bioquímicos de função renal, lesão muscular e lipidograma. RESULTADOS: A análise estatística dos resultados mostrou um aumento significativo (p < 0,05) na atividade sérica das enzimas CK, CK-MM, CK-MB e LDH; na concentração sérica de creatinina, ferro sérico, leucócitos e neutrófilos. Por outro lado, triglicérides, VLDL e ácido úrico sérico apresentaram um decréscimo significativo. CONCLUSÃO: O presente estudo mostra que os atletas analisados apresentam alterações nos parâmetros bioquímicos de sangue e urina após uma prova dessa modalidade, o que demonstra a importância da realização de exames laboratoriais como forma de diagnóstico de distúrbios bioquímicos silenciosos.

OBJECTIVE: The aim of this study was to analyze biochemical markers as indicators of athletic performance, in light of a clinical context and athletic. METHODS: Samples of peripheral blood (8 mL) and urine (50 mL) were collected from 20 marathon athletes at rest and 15 minutes after half marathon. Following, examination of blood, urine and serum markers of renal function, muscle damage and lipidic profile was carried out. RESULTS: Statistical analysis of the results showed a significant increase (p < 0.05) in serum activity of the enzymes CK, CK-MM, CK-MB and LDH, serum creatinine and iron, leukocyte count and neutrophils. Furthermore, triglycerides, VLDL, uric acid in serum showed a significant decrease. CONCLUSION: This study shows that athletes of marathon show changes in biochemical parameters of blood and urine after competing in this modality, which demonstrates the importance of carrying out laboratory tests as diagnosis for silent biochemical disorders.

Kocher-Debre-Semelaigne syndrome: hypothyroidism with muscle pseudohypertrophy.

Kocher-Debre-Semelaigne syndrome is a rare association of muscular pseudohypertrophy and hypothyroidism in children. We report two cases of this syndrome in this communication. The first case was a seven-years-old female who presented with features of hypothyroidism and muscle pseudohypertrophy. The second child had similar manifestations but was only fifteen months of age at diagnosis. This is one of the youngest patients reported to have the Kocher-Debre-Semelaigne syndrome. A short review of the literature is also presented.