Your browser doesn't support javascript.
loading
Montrer: 20 | 50 | 100
Résultats 1 - 2 de 2
Filtre
Ajouter des filtres








Gamme d'année
1.
Mem. Inst. Oswaldo Cruz ; 109(1): 29-37, 02/2014. tab, graf
Article Dans Anglais | LILACS | ID: lil-703641

Résumé

Rheumatoid arthritis (RA) is an autoimmune disease characterised by the destruction of articular cartilage and bone damage. The chronic treatment of RA patients causes a higher susceptibility to infectious diseases such as tuberculosis (TB); one-third of the world’s population is latently infected (LTBI) with Mycobacterium tuberculosis (Mtb). The tuberculin skin test is used to identify individuals LTBI, but many studies have shown that this test is not suitable for RA patients. The goal of this work was to test the specific cellular immune responses to the Mtb malate synthase (GlcB) and heat shock protein X (HspX) antigens of RA patients and to correlate those responses with LTBI status. The T-helper (Th)1, Th17 and Treg-specific immune responses to the GlcB and HspX Mtb antigens were analysed in RA patients candidates for tumour necrosis factor-α blocker treatment. Our results demonstrated that LTBI RA patients had Th1-specific immune responses to GlcB and HspX. Patients were followed up over two years and 14.3% developed active TB. After the development of active TB, RA patients had increased numbers of Th17 and Treg cells, similar to TB patients. These results demonstrate that a GlcB and HspX antigen assay can be used as a diagnostic test to identify LTBI RA patients.


Sujets)
Adulte , Sujet âgé , Femelle , Humains , Mâle , Adulte d'âge moyen , Antigènes bactériens/immunologie , Polyarthrite rhumatoïde/immunologie , Protéines bactériennes/immunologie , Tuberculose latente/diagnostic , Malate synthase/immunologie , Mycobacterium tuberculosis/immunologie , Lymphocytes T régulateurs/immunologie , Analyse de variance , Polyarthrite rhumatoïde/complications , Test ELISA , Cytométrie en flux , Immunité cellulaire/immunologie , /sang , Études longitudinales , Tuberculose latente/complications , Tuberculose latente/immunologie , Agranulocytes/immunologie , Lymphocytes auxiliaires Th1/immunologie , /immunologie , Facteur de croissance transformant bêta/analyse , Facteur de nécrose tumorale alpha/immunologie
2.
Braz. j. infect. dis ; 13(6): 417-421, Dec. 2009. tab, ilus
Article Dans Anglais | LILACS | ID: lil-546010

Résumé

Tuberculosis (TB) is one of the oldest human infectious diseases and one third of the world's population is latently infected. Brazil is an endemic area for TB. One of the most important challenges in TB control is the identification of latently infected individuals. Health Care Workers (HCW) are at high risk of being infected with Mycobacterium tuberculosis and even to become TB latently infected. The aim of this study was to increase knowledge about humoral immune response in TB latently infected individuals. HCW were classified according to their tuberculin skin test (TST), as positive or negative. The antibody response to GLcB, MPT51 and HSPX from Mycobacterium tuberculosis was evaluated. TST negative HCW constituted the majority of those who showed a humoral immune response. Antibody levels varied according to antigen characteristics, TST and BCG status. We suggest that possibly the presence of those antibodies could have a function in the protective immune response against Mycobacterium tuberculosis.


Sujets)
Adulte , Femelle , Humains , Mâle , Adulte d'âge moyen , Antigènes bactériens/immunologie , Protéines bactériennes/immunologie , Tuberculose latente/immunologie , Malate synthase/immunologie , Mycobacterium tuberculosis/immunologie , Personnel hospitalier , Test ELISA , Immunoglobuline G/immunologie , Immunoglobuline M/immunologie , Tuberculose latente/microbiologie
SÉLECTION CITATIONS
Détails de la recherche