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Journal of Korean Medical Science ; : 160-164, 2006.
Article Dans Anglais | WPRIM | ID: wpr-71335

Résumé

Here we report two cases of isolated diffuse mesangial sclerosis (IDMS) with early onset end-stage renal failure. These female patients did not show abnormalities of the gonads or external genitalia. Direct sequencing of WT1 PCR products from genomic DNA identified WT1 mutations in exons 8 (366 Arg>His) and 9 (396 Asp>Tyr). These mutations have been reported previously in association with Denys-Drash syndrome (DDS) with early onset renal failure. Therefore we suggest that, at least in part, IDMS is a variant of DDS and that investigations for the WT1 mutations should be performed in IDMS patients. In cases with identified WT1 mutations, the same attention to tumor development should be required as in DDS patients, and karyotyping and serial abdominal ultrasonograms to evaluate the gonads and kidney are warranted.


Sujets)
Femelle , Humains , Nourrisson , Nouveau-né , Séquence nucléotidique , ADN/composition chimique , Analyse de mutations d'ADN , Issue fatale , Mésangium glomérulaire/anatomopathologie , Mutation , Néphrosclérose/génétique , Protéines WT1/génétique
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