Résumé
A study was made on Langerhans cells (LC) in the dermal lesions of leprosy after epicutaneous application of 2:4 dinitrochlorobenzene (DNCB) to the lesion. LC were quantitated with OKT6 monoclonal antibody and indirect immunofluorescence. A depletion or reduction in the numbers of CD1+ epidermal LC was observed at both 4 and 24 hours after the application of DNCB in the lesions of both tuberculoid and lepromatous leprosy, compared to untreated lesions.
Sujets)
Administration par voie cutanée , Anticorps monoclonaux , Numération cellulaire/effets des médicaments et des substances chimiques , 1-Chloro-2,4-dinitro-benzène/usage thérapeutique , Humains , Cellules de Langerhans/effets des médicaments et des substances chimiques , Lèpre lépromateuse/traitement médicamenteux , Lèpre tuberculoïde/traitement médicamenteuxRésumé
The effects of an amino acid L-glutamine on aspirin-induced gastric lesions as well as on the mast cell population were studied in rats. L-glutamine had a pronounced inhibitory effect on gastric lesions produced by oral aspirin administration. Aspirin-induced increase in the mast cell population of the stomach was also prevented. Parenteral administration of aspirain did not produce any significant damage to the gastric mucosa.