Résumé
Non steroidal anti-inflammatory drugs (NSAID's) are one of the most commonly used agents in clinical practice today. All these drugs are known to produce gastro-intestinal lesions. In the present study we found that aspirin, indomethacin and phenylbutazone caused gastric mucosal damage in 90.9%, 100%, respectively while ibuprofen and paracetamol caused gastric mucosal damage in 33.3% and 37.5% respectively. Thus latter two drugs were safer NSAID's. Further more we have demonstrated that endoscopic monitoring of the patients on NSAID's is a sensitive method of early detection of gastric mucosal damage. This monitoring may be particularly valuable in high risk subjects on NSAID's.
Sujets)
Acétaminophène/effets indésirables , Adolescent , Adulte , Sujet âgé , Anti-inflammatoires non stéroïdiens/effets indésirables , Acide acétylsalicylique/effets indésirables , Femelle , Muqueuse gastrique/effets des médicaments et des substances chimiques , Gastrite/induit chimiquement , Gastroscopie , Humains , Ibuprofène/effets indésirables , Indométacine/effets indésirables , Mâle , Adulte d'âge moyen , Oxyphenbutazone/effets indésirablesRésumé
O autor apresenta um resumo das mais importantes reaçöes hematológicas adversas secundárias a produtos químicos e/ou drogas de uso clínico. Destaca a conduta médica de prevençäo e tratamento nestes casos. Além disso, o autor apresenta um breve sumário da experiência da disciplina de Hematologia Clínica da FCM - UNICAMP em Aplasia Medular, com destaque às causas prováveis mais importantes