Effects of intrauterine administration of oxytetracycline on uterine involution in the ewe

After parturition, the genital system is returning to its normal non-pregnant state. The reduction in the size of the genital tract is called involution. Involution of the ovine uterus after parturition was investigated following the intrauterine administration of oxytetracycline [2 gr]. Under general anaesthesia and using strict asepsis the genital tract of ewes in 2nd month of gestation were exteriorised through a posterior midline laparatomy and four non-toxic split aluminium shots with different sizes were sutured to the wall of the uterine horns and internal os of the cervix [Radio-opaque markers method]. Then, for assessment of uterine involution sequential radiographs were taken on the day of lambing and 3, 7, 14, 28 and 42 days after parturition. Three measurements [uterine body length, gravid and non-gravid horn diameter] were made on each of the radiographs. Involution of the uterine body length and gravid horn diameter were completed by about 28 days after parturition in sterile water treated [Control] group [n = 6] whereas completion of the non-gravid horn involution was significantly more rapid [by about 14 days after parturition] than gravid horn [P<0.05]. The mean of the uterine body length, gravid and non-gravid horn diameter of oxytetracycline administered [treatment] ewes [n = 4] at any stages after parturition were non significantly higher than the control group [P>0.05]. The mean of three measurements of the treatment [n = 4] group at the day 42 were similar to the control group at the day 14 after lambing. However, the present study demonstrates that treatment with intrauterine oxytetracycline may prolong involution of the reproductive tract of ewes after parturition

Andrological responses to prolonged administration of oxytetracycline and metronidazole with reference to the serum testosterone level in rats

In this study, the effect of daily administration of oxytetracycline Hcl [2 mg100 gm. b. wt. i.m] or metronidazole [15 mg/100 gm. b. wt. orally] for 60 successive days on fertility of male rats was investigated. Histological changes of male sex organs were analysed. These drugs insignificantly decreased epididymal sperm cell concentration compared with the control. Non significant changes were observed in the rate of sperm motility and head abnormalities. Oxytetracycline or mertonidazole had no significant effects on the weight of testes, epididymes and accessory sex organs. These drugs induced insignificant changes in serum testosterone level of treated rats