Case report of myeloperoxidase deficiency associated with disseminated paracoccidioidomycosis and peritoneal tuberculosis

Abstract Myeloperoxidase (MOP) is present in monocyte and neutrophil lysosomes, catalyzing hydrogen peroxide and chloride ion conversion to hypochlorous acid. MOP seems to destroy pathogens during phagocytosis by neutrophils and is considered an important defense against innumerous bacteria. We present a patient who had MOP deficiency, who presented with a subacute form of paracoccidioidomycosis and later with peritoneal tuberculosis. MOP deficiency leads to the diminished destruction of phagocytized pathogens. This case gives important evidence of an association between MOP deficiency and increased susceptibility to infection by Paracoccidioides brasiliensis and Mycobacterium tuberculosis.

Tuberculosis peritoneal con presentación clínica como cáncer ovárico avanzado: revisión de la literatura / Peritoneal tuberculosis with clinical presentation as advanced ovarian cancer

Se presenta el caso de paciente con ascitis, masa pelviana y CA 125 elevado, sugerentes de cáncer ovárico avanzado. Se realizó laparoscopía que demostró lesiones compatibles con tuberculosis peritoneal. La biopsia laparoscópica de las lesiones demostró granulomas, por lo que no se realizó más cirugía y se inició tratamiento antituberculoso específico con buena respuesta clínica. Se revisa en la literatura tuberculosis peritoneal y su dificultad con el diagnóstico diferencial con cáncer de ovario avanzado.

It is presented the case of a patient with ascites, pelvic mass and elevated CA 125, all suggested of advanced ovarian cancer. It was made a laparoscopy that evidenced lesions of peritoneal tuberculosis. The laparoscopic biopsy of the lesions demostrated granulomas, for that there was no more surgery made and antituberculosis specific treatment was started, with good clinical response. It is revisited in the literature peritoneal tuberculosis and its difficult differential diagnoses with advanced ovarian cancer.

Tuberculosis peritoneal: informe de siete casos / Peritoneal tuberculosis: report of seven cases

Introducción: La tuberculosis peritoneal es una entidad clínica con baja frecuencia de presentación y por mucho tiempo casi olvidada de la práctica clínica. Casos clínicos: Presentación y análisis de siete casos con diagnóstico de tuberculosis peritoneal, tratados en cuatro hospitales de la ciudad de Aguascalientes, en un periodo de cinco años, que presentaron las siguientes características: edad promedio de 47.5 ± 6.5 años; seis de ellos del sexo femenino y uno del masculino. Dos pacientes tenían el antecedente de tuberculosis pulmonar. Los datos clínicos más relevantes fueron dolor abdominal en seis, ascitis en cuatro y dolor abdominal en tres. El tiempo de evolución promedio de los síntomas fue de 5 ± 1.7 meses. Los hallazgos tomográficos identificados fueron tumor ovárico unilateral en cuatro y bilateral en dos, ascitis en cuatro y adenopatía retroperitoneal en uno. A los seis pacientes del sexo femenino se les encontró niveles elevados de CA125, con mediana de 419 U/ml (286 a 512 U/ml). Se sospechó neoplasia maligna en el preoperatorio en todos los casos, por lo que fueron operados en forma electiva. Se realizó laparotomía con biopsia en tres, laparotomía con salpingo-ooforectomía en dos y laparoscopia con biopsia en dos. Se sospechó tuberculosis peritoneal al momento de la cirugía en todos. El promedio de estancia hospitalaria fue de 2 ± 0.5 días. No se presentaron complicaciones ni muertes hospitalarias. Conclusiones: La tuberculosis peritoneal es una enfermedad rara que se presenta cada vez con mayor frecuencia. Debe considerarse el diagnóstico en pacientes jóvenes con tumor anexial, ascitis y elevación de CA125.

BACKGROUND: Peritoneal tuberculosis (TB) is a misdiagnosed clinical entity of low frequency. Due to its rarity, it requires a high index of suspicion in clinical practice. Its incidence has been increasing in recent years. CLINICAL CASES: We present and analyze seven cases of peritoneal TB diagnosed and treated at four hospitals in Aguascalientes, Mexico during a 5-year period. Mean age of the patients was 47.5 +/- 6.5 years. There were six females and one male. Two patients had a history of treated lung TB. The most frequent clinical data were abdominal pain (six patients), ascites (four patients), and abdominal tumor (three patients). Symptom duration prior to surgery was 5.0 +/- 1.7 months. Abdominopelvic CT examinations revealed unilateral ovarian tumor in four patients, bilateral ovarian tumor in two patients, ascites in four patients, and retroperitoneal adenopathy in one patient. All female patients had elevated serum CA-125 levels with a median of 419 U/ml (range: 286-512 U/ml). All patients had a preoperative diagnosis of malignant tumor. All surgical procedures were elective and consisted of laparotomy with biopsy in three patients, laparotomy with salpingo-oophorectomy in two patients, and laparoscopy with biopsy in two patients. Diagnosis of TB was suspected in all cases during surgery. Mean hospital stay was 2 +/- 0.5 days. There was no postoperative morbidity or mortality. CONCLUSIONS: Peritoneal TB is uncommon. Diagnoses should be considered in all patients with ascites, adnexal tumors and elevated serum CA-125 levels.

Frequency and predictive factors of granulomatous hepatitis in patients with peritoneal tuberculosis

The aims of our study were to determine the frequency of granulomatous hepatitis in patients with peritoneal tuberculosis, to identify factors for high risk and whether it is associated with higher frequency of antituberculous treatment side effects. We carried out a prospective study on patients with histologically proven peritoneal tuberculosis between January 1996 and December 2005. We performed a liver biopsy in all the patients before starting the antituberculous treatment. Granulomatous hepatitis was systematically searched in all patients. The study was conducted in 52 patients, 9 men and 43 women of median age of 35,5 years. A granulomatous hepatitis was seen in 24 patients [46%]. In univariate analysis the factors associated with a high risk of liver involvement were a higher level of gamma-G1utamyl transpeptidase [44.5 + 36.8 lU/l vs 23.3 + 9.28 lU/I p=0.005], a higher level of phosphatases alkalines [233.9 + 96.6 lU/l vs 189.4 + 49.9 lU/l p=0.03] and a lower level of cholesterol [1.22 + 0.2 g/l vs 1.56 + 0.3 g/l p<0.0001]. In multivariate analysis, only a cholesterol level lower than 1,31 g/l was significantly associated with a granulomatous hepatitis [p=0.006 OR [IC95%]: 0.10 [0.02-0.52]]. We have found a frequent liver involvement in the case of peritoneal tuberculosis [46%]. Cholesterol level lower than 1,31 gr/l was an independent predictor of granulomatous hepatitis in patients with peritoneal tuberculosis. We suggest, in this case, that percutaneous liver biopsy can be considered as an alternative to laparoscopy

Peritoneal tuberculosis with gastric cancer: a case report / Tuberculosis peritoneal con cáncer gástrico: reporte de caso

This is a report of a case with both peritoneal tuberculosis and gastric cancer. Physicians should have a high index of suspicion of peritoneal tuberculosis if the patient is febrile with a past history of tuberculosis.

Este es el reporte de un caso con tuberculosis peritoneal y cáncer gástrico a la vez. Los médicos debáan tener un alto índice de sospecha de tuberculosis peritoneal si se trata de un paciente febril con antecedentes de tuberculosis.

Pseudocisto peritoneal por tuberculose: relato de caso / Peritoneal pseudocyst by tuberculosis: case report

A tuberculose peritoneal sempre constitui-se em forma rara de aparecimento da doença e através dos bons resultados obtidos com seu controle endêmico, ainda mais difícil é o diagnóstico da forma abdominal, pois as equipes médicas não estão mais acostumadas a pensar nesta possibilidade...

Peritoneal tuberculosis is frequently forgotten when the medical team face an abdominal distress without evidence of a known disease. The endemic control promoted a decrease in cases mainly on it's abdominal form...

Tuberculose peritoneal: análise de 12 casos / Peritoneal tuberculosis: analysis of 12 cases

A tuberculose peritoneal é uma situação rara com alta morbidade e mortalidade, sendo que o prognóstico depende do diagnóstico e tratamento precoces. Nos últimos anos tem havido aumento de incidência nos países desenvolvidos, principalmente em pacientes imunocomprometidos. Foram analisados retrospectivamente 12 pacientes com tuberculose peritoneal (7 homens, média de idade: 51 anos). As manifestações clínicas, comorbidades e métodos diagnósticos foram revisados. Ascite foi a manifestação mais prevalente. Tuberculose pulmonar associada estava presente em apenas 25% dos pacientes. A biópsia de peritônio foi diagnóstica em todos os casos. Deve haver alto grau de suspeita para estabelecer o diagnóstico de TBC peritoneal (AU)

Peritoneal tuberculosis is a rare condition with high morbidity and mortality, and the prognosis depends of the early diagnosis and treatment. The incidence has been growing in the last years in developed countries, mainly in immunocompromised patients. Twelve patients with peritoneal tuberculosis were retrospectively studied (7 men, mean age 51 years). Data concerning to clinical manifestations, comorbidities and diagnostic methods were obtained. Ascites was the great manifestation. Pulmonar tuberculosis was associated in 25% of patients. Peritoneal biopsy was diagnostic in all patients. To make the diagnosis of peritoneal tuberculosis a high grade of suspicion is necessary (AU)

Reversible segmental portal hypertension--an unusual presentation of abdominal tuberculosis in a renal transplant recipient.

Infections are the commonest cause of morbidity and mortality in renal transplant recipients. In India, tuberculosis is a one such common infection in these patients and presents with protean manifestations. We report here a case of pyrexia of unknown origin (PUO) and segmental portal hypertension in a renal transplant recipient. Search for the cause of portal hypertension revealed abdominal tubercular lymphadenitis. Treatment with anti-tubercular therapy caused regression of segmental portal hypertension.

Tuberculosis genital y CA-125 elevado / Genital tuberculosis and high CA-125 titles

Se presenta caso de tuberculosis genital en mujer joven con títulos altos de CA-125 y diagnóstico inicial de carcinomatosis peritoneal de probable origen ovárico. Se compara hallazgos con lo reportado en la literatura a tráves de los 20 años en Medline y se discute su tratamiento

Ascitic fluid cholesterol in malignant and tubercular ascites.

Cholesterol was estimated in ascitic fluid of 44 patients (29 malignant and 15 tubercular). Mean ascitic cholesterol level was significantly higher in malignant ascites (89.52 mg/dl) as compared to tubercular ascites (35.07 mg/dl). At a cut off value of 54.5 mg/dl (mean in tubercular ascites + 2SD), the sensitivity, specificity, positive and negative predictive value and overall diagnostic accuracy for differentiating malignant from tubercular ascites was found to be 89.65%, 100%, 100%, 83.33% and 93.18% respectively. Ascitic fluid cholesterol estimation is a reliable and simple test for differentiating malignant ascites from tubercular ascites.

Tuberculose peritoneal / Peritoneal tuberculosis

Os autores apresentam dois casos de tuberculose peritoneal em pacientes do sexo feminino (uma com 17 e outra com 52 anos de idade), tecendo comentários sobre alguns aspectos do diagnóstico e tratamento

Abdominal mycobacterial infection in acquired immunodeficiency syndrome patients

The authors studied 12 patients with AIDS and abdominal mycobacteriosis hospitalized in the Hospital lpiranga (Sao Paulo, Brazil), from June 1989 to January 1992. Diagnosis was confirmed by the histopathological examination of organ specimens collected during laparotomy, which, in most cases, was carried out due to an emergency situation. Observations included perforation of the ileum, seropurulent fluid involved and bloked by viscera, epiploon, and fibrin. Hepatoesplenomegaly was present in all patients and generalized granulomatous peritonitis was observed in more than 50 percent. A patient died in the immediate post-op period, four after an average period of 55 days in the hospital. A patient evolved with stercoral fistula and asked to be discharged. Six patients were discharged after an average hospitalization period of 27 days. The authors stress that in developing regions where tuberculosis incidence is high, a patient with AIDS and a painful and irritative abdominal picture should always lead to the hypothesis of mycobacteriosis.

Tuberculosis peritoneal como diagnóstico diferencial de tumor de ovario: presentación de un caso

Se presenta el caso clínico de una paciente remitida al I.N.C. con diagnóstico de Tumor de Ovario, en un puerperio de 8 meses, a quienes se le realizarán los estudios complementarios y de extensión y se lleva a laparotmía con diagnóstico de Tumor de ovario. Los hallazgos intraoperatorios, la biopsia por congelación y la patología definitiva confirman la presencia de una TBC peritoneal con compromiso anexial, endometrial y ganglionar

Exudative v/s transudative ascites: differentiation based on fluid echogenicity on high resolution sonography.

Real time sonography was performed in 52 patients with ascites to evaluate the accuracy of sonography in differentiating an exudative from a transudative collection. The echogenicity of ascites was graded I, II and III using the echogenicity of normal abdominal viscera as comparative standard reference points. Grade I collections (31 patients) were either absolutely anechoic, or showed few internal echoes secondary to particulate matter. Grade II collections (7 patients) were hypoechoic as compared to the liver and spleen. Grade III collections (14 patients) had an echogenicity similar to or greater than that of the liver and spleen. The results of diagnostic aspiration in all patients were then compared to the sonographic grade of the ascitic fluid. All transudates (28 patients) had a Grade I echogenicity. Only 3 patients with an exudative ascites had a Grade I echogenicity. The remaining 21 patients with an exudative collection had an echogenicity equal to or greater than Grade II. Using these results, an ascitic fluid echogenicity of Grade I had a 92.32% sensitivity, 100% specificity, a positive predictive value of 1 and a negative predictive value of 0.875 in diagnosing transudates. An ascitic fluid echogenicity of Grade II or more had a sensitivity of 87.5%, specificity of 100%, a positive predictive value of 1 and a negative predictive value of 0.903 in diagnosing transudates.