Sujets)
Amiodarone/analogues et dérivés , Animaux , Antiarythmiques/pharmacologie , Troubles du rythme cardiaque/traitement médicamenteux , Fibrillation auriculaire/traitement médicamenteux , Flutter auriculaire/traitement médicamenteux , Composés hétérocycliques bicycliques/usage thérapeutique , Cyclopropanes/usage thérapeutique , Agrément de médicaments , Humains , Imidazoles/pharmacologie , Imidazolidines , Phénéthylamines/pharmacologie , Pipérazines/pharmacologie , Sulfonamides/pharmacologieRésumé
1. The effects of ß-phenylethylamine (PEA) alone and in association with caroxazone, a potent inhibitor of monoamine oxidase B (MAO B), on the activity and long-term memory in the wheel-shaped activity monitor and on fixed-interval two-way avoidance acquisition were studied in rats. In a separate study, we determined the effects of PEA and of d-amphetamine on the variable-internal two-way avoidance acquisition. 2. The action of PEA was markedly different from that of aplhetamine in several aspects. The stimulating effects of PEA in the wheel-shaped activity monitor were of a more subtle nature than those of amphetamine and in the variable-interval two-way avoidance acquisition PEA had no effect, while amphetamine improved performance. 3. PEA did not induce an increase in path-choice stereotypy, but caroxazone did. The absence of any caroxazone-session interaction effects on the path interation frequency suggested that there were no long-term memory effects. 4. In the fixed-interval two-way avoidance acquisition experiments, PEA increased the avoidance responses of tats while caroxazone had no effect. The association of the two drugs did not potenciate either