Résumé
Abstract: A 63-year-old black female patient with blisters and exulcerations on the face, neck, upper limbs, and subsequent evolution with hypochromic sclerotic areas and alopecia, is reported. Chronic hepatitis C and presence of high levels of porphyrins in urine were demonstrated. There was complete remission with the use of hydroxychloroquine, photoprotection, and treatment of hepatitis. Significant sclerodermoid involvement of the skin as a manifestation of porphyria cutanea tarda secondary to hepatitis C emphasizes the importance of diagnostic suspicion regarding skin manifestation in order to indicate the appropriate therapy, and to minimize the hepatic morbidity.
Sujets)
Humains , Femelle , Adulte d'âge moyen , Sclérodermie localisée/étiologie , Porphyrie cutanée tardive/étiologie , Porphyrie cutanée tardive/anatomopathologie , Hépatite C chronique/complications , Hépatite C chronique/anatomopathologie , Sclérodermie localisée/anatomopathologie , Sclérodermie localisée/thérapie , Résultat thérapeutique , Porphyrie cutanée tardive/thérapie , Hépatite C chronique/thérapie , Alopécie/étiologieRésumé
Abstract: This is a case report about Porphyria cutanea tarda (PCT) and its relationship with the infection caused by the human immunodeficiency virus (HIV). Cutaneous porphyria is an illness caused by enzymatic modification that results in partial deficiency of uroporphyrinogen decarboxylase (Urod), which may be hereditary or acquired. Several studies suggest that HIV infection associated with cofactors might trigger the development of porphyria cutanea tarda. In this case report, we present a patient infected with HIV, who after the introduction of antiretroviral therapy (ART) enjoyed clinical improvement of porphyria cutanea tarda symptoms.
Sujets)
Humains , Mâle , Adulte d'âge moyen , Infections à VIH/complications , Porphyrie cutanée tardive/anatomopathologie , Porphyrie cutanée tardive/virologie , Peau/anatomopathologie , Uroporphyrinogen decarboxylase/urine , Infections à VIH/traitement médicamenteux , Facteurs de risque , Porphyrie cutanée tardive/traitement médicamenteux , Thérapie antirétrovirale hautement activeRésumé
Porphyria cutanea tarda is prevalent in connective tissue disease, common in systemic lupus erythematosus. However, the co-existence of primary sjogren's syndrome and porphyria cutanea tarda is rare and poses diagnostic and therapeutic challenges. We report a case of porphyria cutanea tarda associated with primary sjogren's syndrome.
Sujets)
Femelle , Humains , Adulte d'âge moyen , Porphyrie cutanée tardive/anatomopathologie , Syndrome de Gougerot-Sjögren/anatomopathologie , Biopsie , Porphyrie cutanée tardive/complications , Saisons , Syndrome de Gougerot-Sjögren/complications , Peau/anatomopathologieRésumé
Os autores fazem uma revisäo da literatura sobre essa entidade e relatam 3 casos ocorridos no HU-UFJF no período de 1992 e 1998 colocando em evidência as principais características clínicas encontradas.