Effect of hydroalcoholic extract of Pycnocycla spinosa on rat isolated bladder contraction

Hydroalcoholic extract of Pycnocycla spinosa is a relaxant of rat ileum and inhibits diarrhea in mice. As P. spinosa extract has spasmolytic activity on ileum, it could also affect other smooth muscles like bladder. Therefore, the aim of this study was to determine the effect of P. spinosa extract on rat bladder contraction. In an in vitro study, the effects of P. spinosa extract, nifedipine and propantheline were tested on isolated rat bladder contractions induced by acetylcholine [ACh, 10 M] and KC1 [80 mM]. P. spinosa extract, concentration-dependently, inhibited the bladder contractions induced by ACh with an IC50 of 265 +/- 28 micro g/ml, and KC1 with an IC50 of 518 +/- 86 micro g/ml. The muscarinic cholinoceptor antagonist, propantheline, inhibited the response of ACh without affecting KC1 response. Nifedipine, on the other hand, abolished the KC1 response, while partially inhibiting the ACh contraction in rat bladder. The antispasmodic effect of P. spinosa extract on bladder was observed at higher concentrations as compared to that of ileum. Therefore, it is unlikely that P. spinosa extract at anti-diarrheal doses affect the normal bladder emptying function

Síncope vagotónico. Manejo con bromuro de propantelina / Treatment of vasovagal syncope with propanthelin bromide

Objetivo: Demostrar la eficacia terapéutica del bromuro de propantelina para evitar recurrencia en síncope vagotónico. Lugar: HGZ No. 3 IMSS, Mazatlán, Sinaloa, México de 1992 a 1995. Pacientes: De 41 pacientes con síncope se incluyeron 10 con síncope vagotónico. Diseño: longitudinal prospectivo. Procedimiento: Se realizó historia clínica, valoración cardiológica y neurológica, electrocardiograma, electroencefalograma, T.A.C., Holter, prueba de esfuerzo y Rx de tórax. Se realizó seguimiento de 10 pacientes por espacio de 12 meses y se midió recurrencia, mejoría de síntomas clínicas y efectos colaterales de bromuro de propantelina 15 a 30 mg cada 8 horas vía oral. Resultados: De 10 pacientes 7 son mujeres, edad promedio 18 años, no hubo recurrencia de síncope en 9 de ellos (p < 0.005), 1abandodó tratamiento, 4 con efectos colaterales leves. Conclusiones: El bromuro de propantelina disminuye la recurrencia de síncope vagotónico con pocos efectos colaterales a 1 año de seguimiento

"Orthoryhthmia" or postural cardiac dysrhythmia: clinical significance.

The objective of present paper is to present results of preliminary observations and studies carried out in fifty individuals developing cardiac dysrhythmia on assuming a supine posture. Detailed history taking, clinical examination, and study of metabolic parameters were carried out. Blood pressure, ECGs and rhythm strips were recorded in supine and upright postures, after exercise and DMT, after i.v. injection of atropine and after oral administration of probanthine. Majority of the individuals studied were asymptomatic. Palpitation was the commonest symptom. Bradycardia was observed in all as well as a low blood pressure. Supraventricular ectopic rhythm was the commonest dysrhythmia observed. Arythmia appeared on assuming a supine posture and tended to disappear in upright position and after exercise. I.v. atropine had a similar effect in a majority of cases, oral probanthine was not very effective. These observations highlight the existence of a hitherto unreported effect of posture on cardiac rhythm. This phenomenon appears to be a benign condition and can be termed as "orthorhythmia".

Experimental and clinical study of the effects of flavoxate in comparison with propantheline

In the present study the pharmacological effects of both flavoxate hydrochloride and propantheline bromide were studied experimentally on urinary bladder strips, intestinal smooth muscles, hearts and aortic strips isolated from rabbits. In-vivo experiments were also carried out to detect their effects on mean arterial blood pressure, heart rate and intraocular pressure of anaesthetized rabbits. In addition, antisecretory effects on basal gastric secretion in rats were investigated. Finally, both drugs were evaluated urodynamically in a clinical study on patients with cystitis. Each of flavoxate and propantheline elicited a significant concentration dependent spasmolytic effect on isolated urinary bladder strips and jejunal smooth muscles. Flavoxate was found to be more selective than propantheline on urinary bladder smooth muscle with potency ratio equal to 38.2. On the other hand, propantheline was found to exhibit a higher selectivity on isolated intestinal smooth muscle with potency ratio equal to 82.2. Comparing the smooth muscle relaxant activity of flavoxate and propantheline on the previous tissues, it was found that flavoxate activity was 237.4 times higher at the urinary bladder while propantheline activity was 13.2 times higher at jejunal smooth muscle. Flavoxate and propantheline displaced the Ach concentration response curves of the rabbit urinary bladder strips to the right. Propantheline and flavoxate produced competitive and weak anticholinergic activities with percentages of antagonistic actions about 83.3% and 33.3% respectively. The Ca [++] antagonistic activity of flavoxate was confirmed in the performed study on CaCl[2] concentration response curves on isolated urinary bladder strips depolarized with KCl, flavoxate produced competitive antagonism with the percentage of 76.5% while propantheline elicited non competitive Ca [++] antagonism with the percentage of 8.8%. Flavoxate also expressed its Ca[++] antagonistic activity on isolated rabbit hearts and aortic strips. Furthermore, in water cystometric recordings for patients with cystitis, flavoxate was more effective in increasing bladder capacity indicating its effect on micturition center, while bladder contractility was decreased more by propantheline denoting its higher antimuscarinic activity

Combination of anticholinergic agent and H2 receptor antagonist in duodenal ulcer treatment--a randomized, double blind multicenter study.

BACKGROUND: The acid suppressive abilities of H2 receptor antagonists and anticholinergics have been claimed to be additive. METHODS: A multicenter, double-blind, randomized trial comparing ranitidine (150 mg) plus propantheline bromide 15 mg at bedtime to ranitidine 300 mg alone at bedtime was conducted in 161 patients with endoscopically confirmed uncomplicated duodenal ulcer. RESULTS: After six weeks of therapy, ulcer healing rates in the two groups were comparable ie 80% in the combination group (ranitidine + propantheline) and 79.4% in the ranitidine group. Pain relief after one, two and four weeks of treatment was also comparable in the two groups. Side effects to drugs were minor and comparable in both the groups. CONCLUSION: A combination of 150 mg ranitidine and 15 mg propantheline bromide is as efficacious as 300 mg ranitidine in inducing healing of uncomplicated duodenal ulcers, with similar side-effects but at greatly reduced cost.

Evaluación comparativa de atropina y propantelina sobre la secreción salival / Atropine and propantheline evaluative comparation of the bodily scretion

Un grupo de 25 pacientes adultos sanos, recibió Atropina parenteral o Propantelina oral, con el fin de valorar y comparar su efecto antimuscarínico, previa estimulación de la secreción salival. Se presentan los resultados obtenidos, al evaluar tanto el efecto farmacológico deseado, como aquellos derivados de la interacción medicamentosa con receptores colinérgicos no ubicados en glándulas salivales.

therapeutic trial of nitrofurantoin versus nitrofurantoin-propantheline for urinary tract infection

A double blind therapeutic trial, using randomly either nitrofurantoin or nitrofurantoin-propantheline combination was carried out on 58 patients with urinary tract infection. Nitrofurantoin alone or in combination had similar cure rate. However, nausea and / or vomiting was significantly higher in the nitrofurantoin group [P< 0.05]. Moreover, side effects in 7 patients among the later group were severe enough to stop treatment. It is suggested that adding propantheline to nitrofurantoin in the treatment of urinary tract infection, more significantly reduces the side effects

Scanning Electron Microscopic Study of the Eccrine Ostia of Mouse Foot Pads After Application of Antiperspirant

Recently, a topical preparation of 5% propantheline bromide and 10% aluminum hydroxychloride in an emulsion ground substance was introduced as an effective antiperspirant. According to the literature, aluminum salts may produce functional closure of swet ducts. Nevertheless, histologic study has as yet failed to reveal a solid anatomic basis for occlusion. In this study, the scanning electron microscope (SEM) was used to demonstrate eccrine gland ostial occlusion due to topical 5% propantheline bromide and 10% aluminum hydroxychloride.

The Effect of a Small dose of Glycopyrrolate and Propantheline on the Heart Rate / 대한마취과학회지

Glycopyrrolate and propantheline, being synthetic quaternary ammonium compounds that cannot cross the blood-brain barrier, will not have the vagal center stimulation. The author administered each small dose of glycopyrrolate and propantenline intravenously to normal human volunteers, and compared its effect on the heart rate. The result were as follows. 1) Glycopyrrolate(0.1mg) produced a slight decrease on the heart rate. 2) Propantheline (0.5mg) produced no detectable change on the heart rate. 3) Glycopyrrolate(0.1mg) 10min. after pretreatment with propantheline(0.5mg) produced a significant increase on the heart rate. 4) Propantheline(0.5mg) 10 minutes after pretreatment with glycopyrrolate(0.1mg) produced more significant increase on the heart rate than glycopyrrolate after propantheline. 5) From the above results, it is suggested that the depressive effect of sympathetic ganglion by propantheline may be less than by glycopyrrolate.

Comparison of Atropine and Propantheline Effects on Human Heart Rate during Ether Anesthesia / 대한마취과학회지

It has been generally understood that belladonna alkaloids in small doses produce bradycardia. However, it is also known that these agents increase heart rate during general anesthesia. In this study, a comparison of atropine and propantheline on human heart rate during ether anesthesia was made and the following results were obtained. 1) Atropine and propantheline increased heart rate. 2) Effect of propantheline on the heart rate was more marked than that of atropine.