1.
Rev. bras. anestesiol
;
45(2): 131-40, mar.-abr. 1995. ilus, tab
Article
Dans Portugais
| LILACS
| ID: lil-166850
2.
Indian J Physiol Pharmacol
;
1975 Apr-Jun; 19(2): 76-80
Article
Dans Anglais
| IMSEAR
| ID: sea-106844
Résumé
Six new substituted acylamides, chemically related to lignocaine were studied for local anaesthetic activity and toxicity in mice, frogs and guinea pigs. Only one of these compounds, w-pyrrolidino 2, 3, 5, 6 tetramethyl acetanilide was found to possess potency comparable to lignocaine with a slightly higher therapeutic index. Study of the S.A.R. of this group indicated that by removal of two methyl groups at position 3 and 5 in the above compound, a local anaesthetic with greater potency than lignocaine may be obtained. Further exploration of the potentialities of a compound having pyrrolidine group as a part of basic side chain is indicated.
Sujets)
Acétanilides/analogues et dérivés , Anesthésie de conduction , Anesthésie locale , Animaux , Anura , Cornée , Diéthylamines/toxicité , Diméthylamines/toxicité , Cochons d'Inde , Dose létale 50 , Lidocaïne/analogues et dérivés , Souris , Morpholines/toxicité , Pipéridines/toxicité , Propylamines/toxicité , Pyrrolidines/toxicité , Relation structure-activité , Queue
3.
Indian J Exp Biol
;
1974 May; 12(3): 252-6
Article
Dans Anglais
| IMSEAR
| ID: sea-62861