Marcadores laboratoriais não tradicionais para aterosclerose: revisão de literatura / Non-traditional laboratory markets for atherosclerosis: review of the literature

As doenças cardiovasculares estão relacionadas com o processo aterosclerótico e o metabolismo lipídico. Apesar da importância dos lipídios sanguíneos na doença cardiovascular, 50 % dos infartos do miocárdio ocorrem em indivíduos sem hiperlipidemia. Nos últimos anos, estudos demonstram fatores de risco emergentes como marcadores de aterosclerose. Lipoproteína-A consiste essencialmente de uma partícula de LDL, limitada pela apoliproteína-a. Lipoproteína-A é associada à presença e extensão da doença coronariana. Proteína-C reativa desempenha um papel na terosclerose e complicações cardiovasculares. Evidências experimentais sugerem que a homocisteína pode estar envolvida na aterogênese e trombogênese. A importância da hiperfibrinogenemia como um fator de risco de aterotrombose...

Serum ferritin level in poorly and well-controlled type 2 diabetic patients attending the outpatient clinics of NIDE

Serum ferritin level is related to body iron stores and is influenced by several diseases. This study was undertaken to evaluate the association between serum ferritin concentration and glycemic control. One hundred and twenty type 2 diabetic patients attending the outpatient clinics of the National Institute of Diabetes and Endocrinology [NIDE] and one hundred and twenty normal healthy controls were involved in this study. We confirmed that serum ferritin was increased in diabetic patients as long as glycemic control is not achieved. Thus, serum ferritin can be recommended as a marker of glycemic control. However, these findings and the possible use of serum ferritin as a predictor of diabetic microangiopathic complications, especially diabetic retinopathy, must be confirmed by additional studies comprising more subjects