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Experimental & Molecular Medicine ; : e77-2014.
Article Dans Anglais | WPRIM | ID: wpr-72396

Résumé

14-3-3zeta is related to many cancer survival cellular processes. In a previous study, we showed that silencing 14-3-3zeta decreases the resistance of hepatocellular carcinoma (HCC) to chemotherapy. In this study, we investigated whether silencing 14-3-3zeta affects the radioresistance of cancer stem-like cells (CSCs) in HCC. Knockdown of 14-3-3zeta decreased cell viability and the number of spheres by reducing radioresistance in CSCs after gamma-irradiation (IR). Furthermore, the levels of pro-apoptotic proteins were upregulated in CSCs via silencing 14-3-3zeta after IR. These results suggest that 14-3-3zeta knockdown enhances radio-induced apoptosis by reducing radioresistance in liver CSCs.


Sujets)
Humains , Protéines 14-3-3/génétique , Antigènes CD/génétique , Protéines régulatrices de l'apoptose/génétique , Carcinome hépatocellulaire/génétique , Lignée cellulaire tumorale , Rayons gamma , Glycoprotéines/génétique , Tumeurs du foie/génétique , Cellules souches tumorales/métabolisme , Peptides/génétique , Radiotolérance
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