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Journal of Korean Medical Science ; : 228-230, 2012.
Article Dans Anglais | WPRIM | ID: wpr-33788

Résumé

A fusion gene between echinoderm microtubule-associated protein-like 4 (EML4) and the anaplastic lymphoma kinase (ALK) has been identified in non-small cell lung cancers (NSCLCs). Although a few studies have evaluated EML4-ALK fusion genes in Korean NSCLCs, the prevalence of different EML4-ALK fusion variants has yet to be clearly assessed. Herein, we have examined the profiles of EML4-ALK fusion gene variants in Korean patients of NSCLCs. EML4-ALK fusion genes have been detected in 10 (6.0%) of 167 patients of NSCLCs and in 9 (7.4%) of 121 patients of adenocarcinoma. Of the 10 patients with fusion genes identified, 8 (80%) were E13;A20 (variant 1) and 2 (20%) were E6;A20, with an additional 33-bp sequence derived from intron 6 of EML4 (variant 3b). These results indicate that the profiles of EML4-ALK fusion gene variants in Korean patients of NSCLC may differ from those in other ethnic populations. Herein, we describe for the first time the profiles of EML4-ALK fusion variants of Korean patients with NSCLCs.


Sujets)
Sujet âgé , Femelle , Humains , Mâle , Adulte d'âge moyen , Adénocarcinome/diagnostic , Asiatiques/génétique , Séquence nucléotidique , Carcinome pulmonaire non à petites cellules/diagnostic , Exons , Introns , Tumeurs du poumon/diagnostic , Protéines de fusion oncogènes/composition chimique , République de Corée , Analyse de séquence d'ARN , Fumer
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