Foliculitis pseudolinfomatosa de McNutt (localización nasal) / McNutt's pseudolymphomatous folliculitis (nasal located)

La foliculitis pseudolinfomatosa, descripta por McNutt en 1986, es una afección de etiología desconocida y poco frecuente, que simula un linfoma cutáneo tanto por su clínica como por su histología. Se presenta como una lesión nodular solitaria, eritematosa, de 0,5 hasta 3cm, de crecimiento rápido, sobre todo en la cara, en personas de 40 a 60 años, con una histopatología caracterizada por un infiltrado linfocitario B yT perifocular, y células dendríticas positivas en la inmunohistoquímica para S100yCD1a. Su curso es benigno, muchas veces autolimitado. Se expone el caso de una paciente con una particular forma clínica de pseudolinforma.

Pseudolymphomatous folliculitis, described by McNutt in 1986, is a non-frequent entity of unknown etiology that simulates a cutaneous lymphoma, both clinically and histologically. It shows as a solitary erythematous nodular lesion of 0.5 to 3 cm, with a rapid growth, mainly on the face, in people aged 40 to 60 years, and histopathology characterized by a perifollicular B and T lymphocytic infiltrate, and positive dendritic cells for immunohistochemistry S100 and CD1a. Its course is benign, often self-limited. The case of a patient with a particular clinical form of pseudolymphoma is presented.

Rosettes in T-cell pseudolymphoma: a new dermoscopic finding

Abstract Rosettes are small white structures visible with polarized light dermoscopy, whose exact morphological correlation is not yet defined. These small shiny structures are found in several conditions such as scarring, dermatofibroma, molluscum contagiosum, squamous cell carcinoma, basal cell carcinoma, melanoma, melanocytic nevus, discoid lupus erythematosus, and papulopustular rosacea. In this novel report, the authors describe the presence of rosettes in a T-cell pseudolymphoma lesion.

Estudios de laboratorio como herramienta en la identificación de apendicitis aguda y su diferenciación con hiperplasia linfoide / Laboratory studies as a tool for the differential diagnosis between acute appendicitis and lymphoid hyperplasia

RESUMEN Antecedentes: La apendicitis aguda (AA) es una de las principales patologías quirúrgicas en México y el mundo. A pesar de ser una patología frecuente, el manejo quirúrgico presenta una tasa del 10-20% de apendicitis blancas (AB) o hiperplasia folicular linfoide (HPL) por histopatología. Objetivo: Comparar los hallazgos clínicos, de laboratorio y radiológicos de pacientes con sospecha de AA con su diagnóstico por histopatología. Material y métodos: El estudio es retrospectivo, observacional y transversal. Se analizaron los datos de los pacientes con diagnóstico clínico de apendicitis aguda, desde febrero de 2013 hasta diciembre de 2017, atendidos en un hospital de tercer nivel en Monterrey, México. Se compararon los hallazgos de los pacientes con diagnóstico de AA vs. HPL, AA no complicadas vs. AA complicadas y pacientes pediátricos vs. adultos. Se realizó un análisis descriptivo por medio de frecuencias y porcentajes, y mediana y rango intercuartil (RIC), dada la distribución no paramétrica de estas variables. Se compararon los hallazgos por laboratorio mediante la prueba de Mann-Whitney. Se consideró una p< 0,05 como estadísticamente significativa. Resultados: En nuestro medio, ambos sexos tienen la misma frecuencia de presentación de AA. El tiempo de evolución es significativo en la presentación frecuente de AA complicada. Existe asociación entre leucocitosis, neutrofilia total y porcentual y recuento plaquetario mayor en presencia de AA vs. HPL. Conclusión: Los estudios de laboratorio no muestran cambios significativos en pacientes pediátricos con AA. En adultos con AA no complicada vs. apendicitis complicada, el aumento en WBC, NEU y NEU% son estadísticamente significativos.

ABSTRACT Background: Acute appendicitis (AA) is one of the main surgical pathologies in our country and worldwide. Despite being a surgery that is frequently done, it is still reported a 10-20% of negative appendectomies (NA). Objective: The objective of the study is to compare clinical, laboratory and radiology results with the histopathology diagnosis. Material and methods: A retrospective study was done analyzing the data of patients with clinical diagnosis of AA from February 2013 to December 2017, in a tertiary hospital in Monterrey, Mexico. They were classified by their histopathological results into different groups: AA or NA; and the AA was subdivided into complicated AA and uncomplicated AA. Finally, these groups were also subdivided by ages, into pediatric and adult groups of each category. A descriptive analysis was made using frequencies, percentages, median and the interquartile range. Laboratory results were compared with the Mann-Whitney test. Considering a p-value of p < 0.05 as statistically significant. Results: In our group of patients both genders had AA in a similar frequency, the time between the appearance of symptoms and reaching for medical advice was an important factor for having complicated AA. There is a correlation between leukocytosis, neutrophil count and platelet count elevated in presence of AA against NA. Conclusion: Laboratory studies did not report significant changes in pediatric patients with AA. In adults with uncomplicated AA vs. complicated AA, white blood cell count, and neutrophil count are statistically significant.

Pseudolinfoma cutâneo: relato de caso / Cutaneous pseudolymphoma: case report

Os pseudolinfomas cutâneos representam um grupo heterogêneo de reações linfoproliferativas benignos que podem simular clinica e histologicamente linfomas cutâneos. O objetivo deste estudo foi relatar a apresentação anatomoclínica de um caso de pseudolinfoma cutâneo para o aperfeiçoamento do seu diagnóstico diferencial com linfomas cutâneos. Paciente do gênero masculino, 66 anos procurou atendimento médico relatando história de nódulos em região superior do dorso há seis anos. Ao exame físico foram observados sete nódulos com aproximadamente 0,5 cm de diâmetro e sem sinais de linfonodomegalias. A biópsia de pele mostrava um denso infiltrado de linfócitos e histiócitos na derme. A análise imuno-histoquímica revelou uma população mista de linfócitos B (CD 20) e linfócitos T (CD 3). O diagnóstico diferencial entre as lesões benignas e malignas é a principal prioridade nesses casos. Tanto o pseudolinfoma, quanto o linfoma cutâneo se manifestam como nódulos solitários, pápulas e placas decorrentes de infiltração linfocitária. Para o diagnóstico diferencial, estão indicadas a avaliação imuno-histoquímica e técnicas de biologia molecular...

Cutaneous pseudolymphoma represents heterogeneous groups of benign lymphoproliferative reactions that may simulate clinically and histologically cutaneous lymphomas. The aim of this study was to report a case of cutaneous pseudolymphoma. Male patient, 66-year-old, came to us reporting a 6-year history of nodules on the upper back. On physical examination we noticed 7 nodules with 0.5 cm of diameter and no sign of adenopathy. The skin biopsy showed a dense infiltrate of lymphocytes and histiocytes in the dermis. The immunohistochemical analysis revealed a mixed population of B lymphocytes (CD 20) and T lymphocytes (CD 3). Differential diagnosis between benign and malignant lesions is the main concern in these cases. In some cases, pseudolymphoma manifests as solitary nodules, papules and plaques that are clinically indistinguishable from cutaneous lymphomas. The differentiation process can be further facilitated by immunohistochemical and molecular biological techniques...

A Korean Woman with Reactive Lymphoid Hyperplasia of the Uvea

No abstract available.

Skin pseudolymphoma caused by cutaneous leishmaniasis

Cutaneous leishmaniasis is a common disease in the Kingdom of Saudi Arabia. A patient with a usual presentation is easy to diagnose by histological examination. However, atypical cases may serve as a problem for both the clinician and the pathologist on the diagnostic level. Here we present a case, in which the clinical presentation and microscopic features mimic cutaneous B-cell lymphoma and pseudolymphoma

Hiperplasia cutánea linfoide (Linfocitoma cutis) secundaria a fármacos: hallazgos clínicos y morfológicos / Cutaneous lymphoid hyperplasia (lymphocytoma cutis) due to drugs: clinical and morphological findings

Pseudolinfoma cutáneo es el término utilizado para indicar un grupo de trastornos linfoproliferativos benignos de la piel, siendo el linfocitoma cutis una forma de seudolinfoma de células B. Clínicamente se manifiesta como nódulos o placas solitarias, generalmente localizados en la cara de mujeres jóvenes. Su etiopatogenia estaría relacionada con una respuesta inmunológica local exagerada ante diversos desencadenantes tales como, picadura de insectos, acupuntura, vacunas, tatuajes, medicamentos e infecciones. Se presentan dos casos de pacientes con diagnóstico de linfocitoma cutis realizado en la Unidad de Anatomía Patológica del Hospital Hernán Henríquez de Temuco.

Cutaneous pseudolymphoma is the term used to indicate a group of benign lymphoproliferative disorders of the skin, being the cutaneous lymphomas a form of B-cell pseudolymphoma. Clinically it manifests as solitary nodules or plaques, usually located on the face of young women. Its pathogenesis could be related to an exaggerated local immune response to various causes such as insect bites, acupuncture, vaccinations, tattoos, drugs and infections. We present two cases of patients diagnosed with skin linfocitoma made in the Pathology Unit in Hernán Henríquez Hospital of Temuco.

Imaging Findings of Localized Lymphoid Hyperplasia of the Pancreas: a Case Report

We report here on a case of localized lymphoid hyperplasia of the pancreas in a 70-year-old man which manifested as double lesions (uncinate process and tail) in the organ. The lesions were incidentally detected as hypoechoic lesions on ultrasonography and they appeared as delayed enhancing lesions on the contrast-enhanced dynamic CT and MRI. Total pancreatectomy was performed, because malignant tumor could not be excluded according to the preoperative imaging studies and the endoscopic ultrasound-guided biopsy failed. Pathology revealed localized lymphoid hyperplasia. The patient had an uneventful postoperative course. He has been alive for 18 months after surgery.

pattern and frequency of diseases associated with lymphadenopathy

A study of 351 patients of lymphadenopathy was carried out to observe the pattern of various diseases with which these patients were affected. There were 168 male and 183 female patients with male to female ratio of 1:1.09. The youngest patient was 1 year old and the oldest was 80 years of age. The commonest lesion found was tuberculosis in 165 [47%] followed by reactive hyperplasia in 121 [34.5%], metastatic carcinoma in 36 cases [10.3%], malignant lymphoma in 27 cases [7.7%], kikuchi's lymphadenitis in one case [0.28%], and fungal lymphadenitis in one [0.28%]

Imunofenotipagem e rearranjo gênico em doenças pulmonares linfocíticas e linfoproliferativas / Immunophenotyping and gene rearrangement analysis in lymphoid/lymphoproliferative disorders of the lungs

OBJETIVO: Determinar a utilidade, na prática rotineira, da análise da clonalidade dos linfócitos T e B nos tecidos pulmonares por reação em cadeia da polimerase no diagnóstico das doenças linfoproliferativas pulmonares. MÉTODOS: Avaliaram-se, mediante análise imunohistoquímica e rearranjo molecular dos genes, 8 casos de pneumonia intersticial linfocítica (PIL) e 7 casos de doenças linfoproliferativas pulmonares. RESULTADOS: Todos os 8 casos de PIL expressaram imunocoloração moderada a forte para CD3, em contraste com apenas 2 casos de linfoma e 1 caso de pseudolinfoma. Rearranjo gênico foi detectado em 4 de 8 casos de PIL, o que mudou o diagnóstico de PIL para linfoma, indicando, assim, a importância da detecção de rearranjo gênico em casos de PIL. Nesta situação, rearranjo gênico usando-se os pares de primers VH/JH e Vgama11/Jgama12 foi detectado em 3 e 1 casos de PIL, respectivamente, e não foram detectadas anormalidades gênicas usando-se as pares Dbeta1/Jbeta2 e Vgama101/Jgama12. Uma associação positiva foi detectada entre a intensidade de imunoexpressão CD20 e CD68 e rearranjo gênico usando-se o par de primers VH/JH. Antes do rearranjo gênico, 4 pacientes com PIL morreram rapidamente, enquanto que, após o rearranjo gênico, apenas 1 paciente com PIL morreu. CONCLUSÕES: A detecção de células B e T monoclonais por imunofenotipagem e reação em cadeia da polimerase mostrou impacto no diagnóstico de linfomas pulmonares em pacientes previamente diagnosticados com PIL. Portanto, imunofenotipagem e reação em cadeia da polimerase devem ser incluídas como métodos de 'padrão ouro' na rotina diagnóstica.

OBJECTIVE: To determine the usefulness, in routine practice, of using polymerase chain reaction to analyze B and T lymphocyte clonality in pulmonary tissue as a tool for the diagnosis of pulmonary lymphoproliferative disorders. METHODS: Immunohistochemistry and molecular gene rearrangement analysis were performed in order to assess 8 cases of lymphoid interstitial pneumonia (LIP) and 7 cases of pulmonary lymphoproliferative disorders. RESULTS: All 8 cases of LIP presented moderate to strong immunostaining for CD3, compared with only 2 cases of lymphoma and 1 case of pseudolymphoma (p = 0.02). Gene rearrangement was detected in 4 of the 8 cases, which changed the diagnosis from LIP to lymphoma, showing the importance of gene rearrangement detection in cases of LIP. In this situation, gene rearrangement using the VH/JH and Vgamma11/Jgamma12 primer pairs was detected in 3 cases and 1 case, respectively, and no gene abnormalities were found using the Dbeta1/Jbeta2 and Vgamma101/Jgamma12 primer pairs in any of the cases. A significant positive association was found between the intensity of CD20 and CD68 expression and gene rearrangement using the VH/JH primer pair. Prior to the gene rearrangement, 4 patients with LIP died quickly, whereas only one patient with LIP died after the gene rearrangement. CONCLUSIONS: Detection of monoclonal B and T cells by immunophenotyping and polymerase chain reaction had an impact on the diagnosis of pulmonary lymphomas in patients previously diagnosed with LIP. Therefore, immunophenotyping and polymerase chain reaction should be used as 'gold standard' techniques in routine practice.

Seudolinfoma cutáneo B, variedad Linfocitoma cutis: a propósito de un caso / CutaneousB-cell pseudolymphoma, Lymphocytoma cutis variety: apropos of a case

Se presenta el caso de una paciente con un seudolinfoma cutáneo de células B variedad Linfocitoma cutis, entidad caracterizada por procesos reactivos de la piel que pueden confundirse clínica e histopatológicamente con linfomas malignos auténticos. El mayor reto que se presenta en estos casos espoder diferenciar estas 2 entidades entre sí, pues ambas se consideran el espectro de una misma entidad, lo cual le confiere varias implicaciones diagnósticas, terapéuticas y patogénicas, por lo que los pacientes se deben mantener bajo vigilancia estrecha. Se revisan aspectos inmunopatológicos, histológicos y terapéuticos. Esta es la primera observación de presentación faciales nuestro medio

The case of a patient is presented with a cutaneous seudolinfoma of cells "B" variety Linfocitoma complexion, entity characterized by processes reagents of the skin that can made a mistake clinic and histopatológicamente with authentic wicked linfomas. The biggest challenge that is presented in these cases espoder to differentiate these 2 entities to each other, because both they are considered the spectrum of oneself entity, that which confers him several implications diagnósticas, therapeutic and patogénicas, for what the patients should be maintained low narrow surveillance. Aspects inmunopatológicos are revised, histológicos and therapeutic. This is the facial first presentation observation our means(AU)

Peripheral lymphadenopathy in children, comparison of fine needle aspiration cytology with open biopsy

To compare the results of Fine Needle Aspiration Cytology [FNAC] with open biopsy in cases of Peripheral Lymphadenopathy. A comparative study. Department of Paediatric Surgery and Department of Pathology, Nishtar Medical College and Hospital, Multan from January 2004 to September 2004. Patients presenting with Peripheral Lymphadenopathy in Paediatric Surgery out patient department were included in study. Relevant history and clinical findings were entered in performa and patients were submitted to investigations like FNAC and open lymphnode biopsy, after getting consent, on OPD basis. Results of both FNAC and histopathology in 54 patients were available for comparison at the end of study. FNAC showed tuberculosis in 36 [66.67%], lymphoproliferative process in 16 [29.63%] and poor yield in 2 [3.71%] cases. Whereas open lymphnode biopsy on histopathology confirmed tuberculosis in 42 [77.78%], Hodgkins lymphoma in 4.[7.42%], Non Hodgkins in 6 [11.13%] and reactive hyperplasia in 2 [3.71%] cases. Sensitivity of FNAC in tuberculosis was 85.7% with a specificity of 100% in cases of tuberculosis while it was 71.5% in cases of lymphomatous process with an overall sensitivity of 78.5% in peripheral lymphadenopathy. In our setup lymphnode biopsy should be performed in all suspected cases to avoid long term morbidity and mortality especially in clinically malignant illnesses

Diagnosis validity of AgNOR staining for differentiating non Hodgkin lymphoma from reactive hyperplasia

There are different methods including H and E, imonhistochemstry, flu cytometry, AgNOR staining for differentiation reactive hyperplasia from lymphoma. This study was done to determine diagnostic validity of AgNOR staining for differentiating non-Hodgkin lymphoma from reactive hyperpalsia. Fifty paraffin blocks belong to patients with confirmed diagnosis are as below: Thirty five block with lymphoma and fifteen blocks with reactive hyperplasia. AgNor dots among one hundred cells were counted, by two experienced pathologists. The mean of AgNOR dots were calculated. Student T- test used to compare mean AgNOR dots. The mean AgNOR count was 2.2 [range 1.4- 3, SD=0.8] in reactive hyperplasia and 6.7 [range 3.9- 9.5, SD=2.8] in non-Hodgkin lymphoma. A statistically significant difference was observed between the AgNOR count of reactive hypeerplasia and non-Hodgkin lymphoma [p<0.05]. The findings support the validity of AgNOR technique for differentiating and confirming non-Hodgkin lymphoma from reactive hyperplasia

Tratamento cirúrgico da ptose palpebral adquirida (linfocitoma cútis) / Surgical treatment of acquired palpebral ptosis (lymphocitoma cutis)

Os autores descrevem um caso clínico de ptose palpebral causada por uma patologia rara, o linfocitoma cútis. A paciente apresentava o quadro clínico do linfocitoma cútis em sua forma disseminada, com sintomatologia visual causada por nódulos palpebrais. A conduta cirúrgica realizada foi a ressecçäo dos nódulos palpebrais por meio de incisÒo de blefaroplastia, e o exame histológico confirmou o diagnóstico de linfocitoma cútis. O tratamento cirúrgico realizado foi eficiente para a melhora funcional das pálpebras.